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University of Colorado Denver

University of Colorado Denver


Faculty Profile

Associate Professor

Division of Endocrinology, Metabolism, Diabetes

University of Colorado Denver


Regulation of Energy Balance


1)    NIH R01 DK077088 " Energy expenditure & activity during exercise-induced weight loss"

2)    NIH R01 HL085705 (Wright) ““Health and Safety Consequences of Sleep Loss”


Description of Research


My research interests are the effects of diet, exercise, and obesity on substrate metabolism and energy expenditure. Currently, we are performing studies on the effects of different intensities of exercise and manipulations in dietary fat on fat oxidation. These studies are performed using whole-room indirect calorimetry. We are also currently performing an exercise intervention aimed at determining the effects of exercise on the different components of energy expenditure, particularly non-resting energy expenditure. In these studies, a variety of approaches are used to assess energy expenditure including doubly labeled water, indirect calorimetry, and accelerometry.



1-2 Most Significant Publications

1)    Melanson, E.L., P.S. Maclean, and J.O. Hill.  Exercise increases fat metabolism in skeletal muscle but does not increase 24 h fat oxidation.  Ex Sci Sports Rev.  37(2):93-101, 2009

2)    Melanson, E.L., T.A. Sharp, H.M. Seagle, T.J. Horton, W.T. Donahoo, G.K. Grunwald, J.T. Hamilton, and J.O. Hill, Effect of exercise intensity on 24-h energy expenditure and nutrient oxidation. J Appl Physiol, 2002. 92(3): p. 1045-52.


Primary Focus Area (if part of the obesity initiative)

·         Regulation of Energy balance


Secondary Focus Areas (if part of the obesity initiative)

·         Obesity and metabolic dysregulation and co-morbities


Access to Specialized Populations

·         NA

·         changes and  continue tracking those changes



Benefit of CNRU

The major benefit of the CNRU for me has been the enhanced interaction and collaboration with other CNRU investigators. Additionally, the CNRU allows me to interact with junior investigators through the pilot project program and through the core laboratories.  The core laboratories of the CNRU are critical to my research success.  These laboratories provide services in a cost-effective manner than I could not develop in my own laboratory. 


CNRU Cores Used

Administrative, Energy Balance, Metabolic

Mass Spectrometry


CNRU Collaborations

Eckel, Hill, Kohrt, MacLean, Barry, Gozansky, Grunwald, Catenacci, Schwartz, Higgins, Bessesen, Cornier, Horton, Ogden
University of Colorado Denver

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