Pulmonary Blood & Lymphatic Vessel Biology in Settings of Inflammation
My primary interest is in how the lung vasculature-blood vessels and particularly lymphatics- operates during episodes of acute and chronic inflammation. To study these phenomena, we examine lung tissue, as well as peripheral blood mononuclear cells and plasma, from patients with pulmonary hypertension. We use two different rat models of pulmonary hypertension, and we are in the process of developing a third that we hope will allow us to test auto-immune and auto-inflammatory processes in the lung vasculature. We combine these models with genetic, pharmacologic, and immune-based modulations. In addition, we are developing 3-D co-culture models that mimic the peri-bronchovascular space. Our future plans for this system are to test the interactions of adventitial fibroblasts and immune cells under biological and pathological interstitial flow conditions. Here, we are keenly interested in both the cell-cell and cell-matrix interactions, and the effect of flow on these interactions and on cell phenotype.
Please download our brochure, which summarizes our research and training activities.
- Determine profiles of peripheral blood mononuclear cells and plasma inflammatory constituents in patients with pulmonary hypertension; examine patient lung tissue for pathobiological differences from controls.
- Determine the role of pulmonary lymphatics and associated lymphoid structures on immune regulation and inflammation in the lung.
- Determine the mechanisms by which resident lung fibroblasts and immune cells communicate and whether such communication controls inflammation.
- Myeloid Suppressor Cells are Increased and Activated in Children and Young Adults with Pulmonary Hypertension. Yeager ME, Nguyen CM, Belchenko DD, Colvin KL, Takatsuki S, Ivy DD, Stenmark KR. CHEST 2011, in press.
- Circulating Fibrocytes are Increased in Children and Young Adults with Pulmonary Hypertension. Yeager ME, Nguyen CM, Belchenko DD, Colvin KL, Takatsuki S, Ivy DD, Stenmark KR. Eur Resp J 2011, in press.
- Endothelin-1, the Unfolded Protein Response, and Persistent Inflammation-Role of Pulmonary Artery Smooth Muscle Cells. Yeager ME, Belchenko DD, Nguyen CM, Colvin KL, Ivy DD, Stenmark KR. Am J Resp Cell Mol Biol, 2011, in press.
- Progenitor Cells in Pulmonary Vascular Remodeling. Yeager ME, Frid MG, Stenmark KR. Pulm Circ, 2011 Jan: 1(1) 3-16.
- Fibrocytes: potential new therapeutic targets for pulmonary hypertension? Stenmark KR, Frid MG, Yeager ME. Eur Respir J. 2010 Dec;36(6):1232-5.
- National Jewish Research & Medical Center. Post-Doctoral Fellow. 2004-2006.
- Universitat Giessen. Post-Doctoral Fellow. 2003-2004.
- University of Colorado Health Sciences Center. Ph.D. 2003. Experimental Pathology.