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Department of Bioengineering

Bioengineering
 

Kendall Hunter, PhD

Assistant Professor - Bioengineering


Contact Information

Telephone: 303-724-4197
E-mail: Kendall.Hunter@ucdenver.edu

Reseach Focus

Soft tissue biomechanics; mechanics-based imaging diagnostics; numerical biomodeling

My interests lie at the intersection of cardiac and pulmonary imaging diagnostics, the experimental and computational modeling of soft tissue mechanics, and animal models of vascular remodeling. I currently focus these three broad topics on examining the development, diagnosis, and progression of pulmonary hypertension. Animal models of the disease have allowed me to make detailed comparisons amongst hemodynamics and vascular mechanics that are impossible to obtain in clinical studies, and are beginning to address how individual extracelluar matrix components of the pulmonary vessels contribute to right heart (RV) afterload. Simple computational studies of the pulmonary vasculature are clarifying the impacts of vascular stiffness in different stages of the disease and in treatment, while analytic models are enabling the creation of novel clinical diagnostics. Finally, translating knowledge gained from these components to clinically-relevant measurements promises to improve disease prognosis.

  • Determining right ventricular pumping efficiency and ventricular-vascular coupling as functions of resistive and compliant afterload in a hypoxic animal model of pulmonary hypertension. Of particular interest: examining the differential impacts of elastin and collagen proximal remodeling on RV functional parameters.
  • Coupling measurements of diameter (via ultrasound) and pressure (via invasive catheter) to assess proximal pulmonary vascular stiffness in children and evaluating this stiffness as a predictor of patient outcomes.
  • Developing and evaluating new minimally invasive (impedance) and noninvasive (relative diameter change, others) diagnostics and prognostics of pulmonary hypertension.
  • Using simple computational models to gain insight into how pulmonary hemodynamics are altered due to changes in vascular stiffening and resistance.
  1. Measurement uncertainty in pulmonary vascular input impedance and characteristic impedance estimated from pulsed-wave Doppler ultrasound and pressure: clinical studies on 57 pediatric patients. Tian L, Hunter KS, Kirby KS, Ivy DD, Shandas R. Physiol Meas. 2010 Jun;31(6):729-48. Epub 2010 Apr 22.
  2. In vivo measurement of proximal pulmonary artery elastic modulus in the neonatal calf model of pulmonary hypertension: development and ex vivo validation. Hunter KS, Albietz JA, Lee PF, Lanning CJ, Lammers SR, Hofmeister SH, Kao PH, Qi HJ, Stenmark KR, Shandas R. J Appl Physiol. 2010 Apr;108(4):968-75. Epub 2010 Jan 21.
  3. Wave scattering from encapsulated microbubbles subject to high-frequency ultrasound: contribution of higher-order scattering modes. Chen J, Hunter KS, Shandas R. J Acoust Soc Am. 2009 Oct;126(4):1766-75.
  4. Noninvasive methods for determining pulmonary vascular function in children with pulmonary arterial hypertension: application of a mechanical oscillator model. Hunter KS, Gross JK, Lanning CJ, Kirby KS, Dyer KL, Ivy DD, Shandas R. Congenit Heart Dis. 2008 Mar;3(2):106-16.
  5. Pulmonary vascular input impedance is a combined measure of pulmonary vascular resistance and stiffness and predicts clinical outcomes better than pulmonary vascular resistance alone in pediatric patients with pulmonary hypertension. Hunter KS, Lee PF, Lanning CJ, Ivy DD, Kirby KS, Claussen LR, Chan KC, Shandas R. Am Heart J. 2008 Jan;155(1):166-74. Epub 2007 Sep 27.

University of Colorado Health Sciences Center. Post-Doctoral Research Fellow. 2004-2006. Bioengineering.
University of Colorado Boulder. Postdoc. 2001-2002. Acoustics, Fluid-Structure Interaction.
University of Colorado Boulder. PhD. 2000. Mechanical Engineering.
University of Colorado, Boulder. MS. 1996. Mechanical Engineering.
New Mexico State University, Las Cruces. BS. 1993. Mechanical Engineering.