Department of Medicine
University of Colorado Denver
mechanisms of Insulin resistance
Grant: 1) VA Career Development Award-2: “Regulation of Egr-1 in Insulin Resistance”
Description of Research
We study factors that contribute to insulin resistance including diet, obesity, and vitamin D deficiency. Our focus is blood vessel dysfunction and disease, which can be an early sign of heart problems, and can lead to decreased quality of life. These studies are being carried out on several levels: in people, in animal models, and in petri dishes, to figure out how these factors make it difficult for the body to use insulin properly.
The studies in people are being carried out with the LUCHAR group, which is interested in reducing cardiovascular disease risk in all populations, but especially the Latino population.
1-2 Most Significant Publications
1) Wang CCL, Goalstone M, Draznin B. Molecular mechanisms of insulin resistance that impact cardiovascular biology. Diabetes 2004;53:2735-2740.
2) Wang CCL. Chapter 12: Insulin resistance and cardiovascular disease. In Insulin Resistance and Metabolic Syndrome: Childhood Precursors and Adult Disease from the Contemporary Endocrinology Series, 2008. Humana Press, New Jersey.
Primary Focus Area (if part of the obesity initiative)
· Comorbidities of obesity and metabolic dysregulation: Vascular dysfunction
Secondary Focus Areas (if part of the obesity initiative)
· Metabolic dysregulation
· Vitamin D deficiency
Access to Specialized Populations
· LUCHAR (Latinos Using Cardiovascular Health Actions to Reduce Risk) – a group of participants with hypertension and at least one other cardiovascular disease risk factor. This study is funded by the NIH NHLBI to figure out the scope of cardiovascular disease risk factors in the Latino population in Denver, and to implement ways to reduce risk in communities.
Benefit of CNRU
The main benefit of the CNRU is the opportunities for interaction and collaboration with other CNRU investigators. Also, the core laboratories of the CNRU are key for my transition to doing physiologic studies and will provide high-quality services in a cost-effective manner.
CNRU Cores to be used
CollaborationsPereira, Dickinson, Estacio, Krantz, Neuman, Long, Havranek, Chonchol, Steiner, Hanratty, Hosokawa, Coyle, Schwartz, Lu, Xu, Greyson, Draznin, Gianani, King, Reusch, Moreau, Norris, the Walkers, Regensteiner.