Structure based drug design targeting transcription factors that regulate epithelial to mesenchymal transition.
Allosteric and dynamic relationships driving the mitotic regulator Pin 1
Biotechnological reprogramming of viruses into therapeutic agents & investigations into dynamic multiparametric metabolic responses of living systems remodeled by pathophysiologic stimuli and/or genetic modifications.
Structural dynamics of acid-sensing ion channels using biophysical and biochemical approaches
Conventional chemotherapy for acute myeloid leukemia eliminates most proliferating bulk tumor cells, but some of the leukemia stem cell population remains. These remaining cells can lead to disease progression and relapse; targeting them would result in better outcomes or even curative therapy for AML patients. Currently, I am working to characterize the aberrant fatty acid metabolism in leukemic stem cells using metabolomics and mass spectrometry, but my research also focuses on characterizing metabolic perturbations in leukemia, how altered pathways contribute to their phenotype, and how they can be targeted for therapeutic use.
My research interest is understanding the molecular mechanism of pre-mRNA splicing and gene expression using biochemical, genetic, and structural approaches
My interests include functional receptor expression, cryo- EM, and neuroscience.
Investigating the function of Olduvai protein domains
RNAs form diverse and complex tertiary structures which relate to their function in cells where many RNA interacting proteins recognizing these folds. My interests relate to these protein-RNA interactions in the context of highly structured non-coding RNAs.
I am primarily interested in studying chromatin structure.
I am interested in understanding how RNA molecules fold and function at a structural level
Molecular recognition of DNA by chromatin assembly factor 1
Lauren's work in the Hansen Lab focuses on characterizing the structure of blood clots through identification of FXIIIa cross-links. Our method utilizing cross-linking mass spectrometry (CL-MS), will allow for the rapid identification of these cross-links and improve our understanding of the structure of a blood clot.
Structural analysis of hte regulation of mitochondrial trafficking in metastasis
Molecular electron microscopy analysis of mouse mediator