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Students and Alumni

Current Students

  
  
Research Interest
Structure based drug design targeting transcription factors that regulate epithelial to mesenchymal transition.
Allosteric and dynamic relationships driving the mitotic regulator Pin 1
Biotechnological reprogramming of viruses into therapeutic agents & investigations into dynamic multiparametric metabolic responses of living systems remodeled by pathophysiologic stimuli and/or genetic modifications.
Structural dynamics of acid-sensing ion channels using biophysical and biochemical approaches
Conventional chemotherapy for acute myeloid leukemia eliminates most proliferating bulk tumor cells, but some of the leukemia stem cell population remains. These remaining cells can lead to disease progression and relapse; targeting them would result in better outcomes or even curative therapy for AML patients. Currently, I am working to characterize the aberrant fatty acid metabolism in leukemic stem cells using metabolomics and mass spectrometry, but my research also focuses on characterizing metabolic perturbations in leukemia, how altered pathways contribute to their phenotype, and how they can be targeted for therapeutic use.
My research interest is understanding the molecular mechanism of pre-mRNA splicing and gene expression using biochemical, genetic, and structural approaches
My interests include functional receptor expression, cryo- EM, and neuroscience.
Investigating the function of Olduvai protein domains
RNAs form diverse and complex tertiary structures which relate to their function in cells where many RNA interacting proteins recognizing these folds. My interests relate to these protein-RNA interactions in the context of highly structured non-coding RNAs.
I am primarily interested in studying chromatin structure.
I am interested in understanding how RNA molecules fold and function at a structural level
Molecular recognition of DNA by chromatin assembly factor 1
Lauren's work in the Hansen Lab focuses on characterizing the structure of blood clots through identification of FXIIIa cross-links. Our method utilizing cross-linking mass spectrometry (CL-MS), will allow for the rapid identification of these cross-links and improve our understanding of the structure of a blood clot.
Structural analysis of hte regulation of mitochondrial trafficking in metastasis
Molecular electron microscopy analysis of mouse mediator

Alumni

  
  
Research Interest
  
Mitochondrial transcription.
2019
Role of JMJD5 and JMJD6 in regulating transcriptional pausing
2019
Biophysics, protein evolution mechanisms and modelling.
2019
Understanding the structural basis of RNA manipulation of ribosomes by IRES RNAs
2018
My research interests involve studying tissue remodleling associated with metastatic and non-metastatic tumors and how these changes are relfected in the composition of the extracelluar matrix.
2017
Suffocating the oxygen carriers: Implications for physiology and transfusion medicine
2017
Advances in Extracellular Matrix Proteomics: Applications towards Regenerative Medicine and Disease
2016
Determination of the Full Catalytic Cycle among Multiple Cyclophilin Family Members and Limitations on the Application of CPMG-RD in Reversible Catalytic Systems
2016
CD147 reprograms pancreatic cancer metabolism via its interaction with small molecule transporters
2016
Quantitative Analysis of Human Tear Fluid
2016
Recipient of the University of Colorado Cancer Center Paul Sandoval Pancreatic Cancer Research Scholarship, "Targeting the Six1-Eya Interaction for Pancreatic Cancer Therapeutics" Targeting protein-protein interactions for potential anti-cancer therapeutics.
2015
Functional Analysis of Phosphorylation of Histone H3 on Threonine 118
2014
Understanding of the Structural and Functional Effect of H50Q alpha-synuclein
2014
Kidney Disfunction Biomarkers for the early Detection of Allograft Injury
2014
Identifying Non-Receptor Tyrosine Kinases which regulate the pro-apoptotic function of PKC delta
2014
​Identification and characterization of specific inhbitors of Eya2 phosphatase
2013
A Stability Control Region in Tropomyosin Transmits Long-Range Effects to Provide Optimum Stability
2012
Cellular Receptors in Cancer: CD147 and Mer
2012

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