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William R. Brown, MD

Professor of Medicine


Professor of Medicine


Education
•Medical School:University of Wisconsin Medical School - MD 1959
•Internship/Residency:
◦Internship - Denver General Hospital, Denver, CO 7/59-6/60
◦Residency in Medicine - Veterans Administration Hospital and University of Colorado Medical Center, Denver, CO 7/60-6/62
•Fellowship: Research Fellow and Assistant Research Physician, University of California (San Francisco) and University of Singapore, 7/62-6/65
•International Center for Medical Research and Training Fellowship in Gastroenterology, University of Colorado 7/65-6/67
•Chief Resident in Medicine, University of Colorado Medical Center 7/67-6/68
•Special NIH Fellow, sponsored by Dr. Kimishige Ishizaka, Director of Research, Children's Asthma Research Institute and Hospital, Denver, Colorado 7/68-6/70
•Board Certified in Internal Medicine


Honors and Awards
•Alpha Omega Alpha Honor Society, University of Wisconsin Medical School, 1958
•Borden Award for Outstanding Research Project in Preclinical Years, University of Wisconsin Medical School, 1959
•Blackwenn Award for Clinical Promise, University of Wisconsin Medical School, 1959
•Veterans Administration Clinical Investigatorship,1971-74
•Visiting Professor, Kyoto University, Kyoto, Japan and Tokai University, Japan (April-October), 1982
•Research Fellowship, Japan Society for the Promotion of Science (April-October), 1982
•Veterans Administration Medical Investigatorship, 1985-91
Faculty Appointments
•Instructor in Medicine, University of Colorado School of Medicine, 1967-68
•Assistant Professor of Medicine, University of Colorado School of Medicine, 1968-74
•Associate Professor of Medicine, University of Colorado School of Medicine, 1974-82
•Professor of Medicine, University of Colorado School of Medicine, 1982-present
•Chief of Gastroenterology, Denver VA Medical Center, 1980-88 and1990-2001
•Acting Head, Division of Gastroenterology, University of Colorado School of Medicine, 1987-88
•Physician, Gastroenterology, Denver Health Medical Center 2002-present
•Interim Head, Gastroenterology Division, Denver Health Medical Center 2009 - present


Research Interests
Immunology of the gastrointestinal tract

Representative Publications
1.Tyler KL, Sokol RJ, Oberhaus SM, Le M, Kanner FM, Murphy JR, Low R, Brown WR: Detection reovirus RNA in hepatobiliary tissues from patients with extrahepatic biliary atresia and choledochal cysts. Hepatology 27:1475-83,1998. (download pdf )
2.Bennet JD, Brown WR, Kotzin BL. Regional variation in the lamina propria T-cell receptor Va repertoire in normal human colon. Clin Imunol 90:38-46, 1999. (download pdf )
3.Vasquez-Torres A, Jones-Carson J, Baumler AJ, Falkrow S, Valdivia R, Brown WR, Le M, Berggren R, Parks WT, Fong F: Extraintestinal dissemination of Salmonella via CD18-expressing phagocytes. Nature 401:804-8, 1999. (download pdf)
4.Kobayashi K, Yagasaki M, Harada N, Chichibu K, Hibi T, Yoshida T, Brown WR, Morikawa M: Detection of Fc y gamma binding protein antigen in human sera and its relationship with autoimmune disease. Immunology Letters 79: 229-35, 2001. (download pdf )
5.Kobayashi K, Ogata H, Morikawa M, Iijima S, Harada N, Yoshida T, Brown WR, Inoue N, Hamada Y, Ishii H, Watanabe M, Hibi T: Distribution and partial characterization of IgG Fc binding protein in various mucin-producing cells and body fluids. Gut 51: 169-76, 2002. (download pdf )
6.Mahnke D, Chen YK, Antillon MR, Brown WR, Mattison R, Shah RJ. A prospective study of complications of endoscopic retrograde cholangiopancreatography and endoscopic ultrasound in ambulatory endoscopy center. Clin Gastroenterol Hepatol 4(7):924-930, 2006. (download pdf)
7.Hasan AG, Brown WR. A model for morbidity-mortality conferences in gastroenterology. Gastrointest Endosc 67:515-519, 2008. (download pdf)