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John M. Stewart, PhD

Professor

Ph.D., University of Illinois, 1952

Dr. John M. Stewart, Denver, Colorado, Professor Emeritus, University of Colorado School of Medicine, Department of Biochemistry and Molecular Genetics, and an internationally renowned scientist in the field of Peptide Chemistry, died December 29th. He was 87.

Dr. Stewart's Obituary

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RESEARCH IN THIS LABORATORY IS ON CHEMISTRY AND BIOLOGY OF PEPTIDES.

Chemistry: This laboratory is well-equipped to carry out synthesis of a wide variety of peptides by the solid phase method. Improvements in synthetic methods are being developed. J.M. Stewart was the designer of the first instrument for automatic peptide synthesis and collaborated with R.B. Merrifield on development of the solid-phase method, for which Merrifield won the Nobel prize. The Stewart laboratory has carried out syntheses of a wide variety of peptides during more than 3 decades of research.

Biology: Current research deals with the following interests: Development of more potent bradykinin antagonists and application of them to the pathophysiology of inflammation and cancer. Physiological roles of the neuropeptide Substance P and elucidation of new SP receptors in the central nervous system. Analogs of luteinizing hormone releasing hormone, opioid peptides, scorpion venom peptides. Study of the rules governing protein folding and the design and synthesis of new enzymes.


Bradykinin antagonists: Present progress and future prospects. J.M. Stewart, L. Gera, E.J. York, D.C. Chan and P. Bunn. Immunopharmacology 43: 155-161, 1999.

Novel bradykinin antagonist dimers for the treatment of human lung cancers. D. Chan, L. Gera, B. Helfrich, K. Helm, J. Stewart, E. Whalley and P. Bunn. Immunopharmacology 33: 201-204, 1996.

Potent, long-acting, orally-active bradykinin antagonists for a wide range of applications. J.M. Stewart, L. Gera, D.C. Chan, E.T. Whalley, W.L. Hanson and J.S. Zuzack. Immunopharmacology 36: 167-172, 1997.

NMR and CD conformational studies of bradykinin and its agonists and antagonists: Application to receptor binding. G. Kotovych, J.R. Cann, J.M.Stewart and H. Yamamoto. Biochem. Cell Biol. 76: 257-266, 1998.

Neuropeptide processing in pathophysiology. J.M. Stewart and M.E. Hall. Agents and Actions 42S: 211-226, 1993.

Studies on chymotrypsin-like catalysis by synthetic peptides. M.J. Corey,. Hallakova, K. Pugh and J.M. Stewart. App. Biochem. Biotechnol., 47:199-212, 1994.

Helix propensities of basic amino acids increase with the length of the side-chain. S. Padmanabhan, E.J. York, J.M. Stewart and R.L. Baldwin. J. Mol. Biol. 257: 726-734, 1996. ​

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