Immunology training in Denver has a long and
distinguished record, with almost all of our trainees going on to
successful careers as scientists, ranging from academia to public
service at NIH, or the CDC, to research in Biotech or with large
Pharmaceutical companies. Our first training grant was awarded in 1991
from the National Institute for Allergy and Infectious Diseases and at
that time served as a catalyst to bring together the diverse
immunologists whose laboratories were located at the University of
Colorado, National Jewish Health, the Barbara Davis Center for Diabetes
and other institutes. This training grant (“Training in Immunology”; T32
AI007405), currently in its 25th year, funds training in any area of
immunology for select graduate students and postdoctoral fellows. Dr.
Philippa Marrack is the PI of this training grant.
Immunology Program Training Grants
training grant, “Molecular Mechanisms of Immune Tolerance” (T32
AI074491), is currently in its 7th year and is supported again by the
NIAID. This training grant funds postdoctoral fellows who investigate
molecular mechanisms of immunologic tolerance and autoimmunity. Dr. John
Cambier is the PI of this training grant.
Together these two training grants provide significant support for the Immunology Training Program in Denver which has been
particularly notable is its continued successful recruitment and
training of a number of underrepresented minorities. Our Immunology
Training Program continues to be a major focus for immunological
research in the Rocky Mountain region in particular and the USA in
Molecular Pathogenesis of Infectious Diseases (MPID)
HIV/AIDS, tuberculosis, acute lower respiratory tract infections, and diarrheal infections are major causes of death, disability, and social and economic disruption for millions of people each year. In addition, emerging, re-emerging and previously unrecognized infections are threats to humans and animals worldwide. Understanding the molecular aspects of infectious diseases provides a rational basis for developing targeted new methods for the diagnosis, prevention, treatment and cure of current and emerging infectious diseases, and for developing effective measures against the use of pathogenic microbes for bioterrorism. The goal of this interdepartmental MPID T32 is to train PhD candidates to investigate the fundamental mechanisms of microbial pathogenesis. This training grant provides pre-doctoral students from multiple graduate programs at the University of Colorado Anschutz Medical Campus (UCAMC) with opportunities to train in diverse aspects of the molecular pathogenesis of infectious diseases. Some of the research areas available to trainees supported by this grant include investigations on the molecular mechanisms of 1) replication and pathogenesis of positive-strand RNA viruses and gammaherpesviruses, 2) pathogenesis and resolution of arbovirus-induced inflammatory responses, 3) papilloma virus-induced cancers, 4) Pseudomonas pathogenesis, 5) Mycobacterium tuberculosis latency and drug tolerance, 6) virus-induced cell death, 7) host responses to intracellular, extracellular and mucosal bacterial pathogens, and 8) drug tolerance of Tier 1 select agents. Our trainees also have opportunities to perform structural and functional studies of bacterial toxins and bacterial redox two-component regulatory proteins, and to study the regulation of microbial gene transcription. Several of our training faculty members are engaged in translational research and study mucosal host-pathogen interactions with Streptococcus pneumoniae, enterotoxigenic Escherichia coli, influenza virus, and HIV and AIDS-related infectious diseases. The efforts of our faculty to understand the microbiome and its impact on disease susceptibility and host defense provide a dynamic area of molecular pathogenesis with local access to high-throughput sequencing and data analysis. These research opportunities are carried out in the laboratories of 24 training grant faculty in 6 different departments.