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Pragmatic Trials & Dissemination/ Implementation Research


Catalyzing and supporting the development of pragmatic trials, comparative effectiveness research methods, and implementation science to achieve increased efficiency and economies of scale. We aim to foster a learning community and serve as a conduit for active dissemination of resources from NIH and other national organizations.

We are partnered with the Adult and Child Center for Health Outcomes Research and Delivery Science (ACCORDS), funded by the University of Colorado School of Medicine and Children’s Hospital Colorado.

Educational and Best-Practice Resources

Colorado Research in Implementation Science Program (CRISP)

NIH Health Care Systems Research Collaboratory

Patient-Centered Outcomes Research Institute (PCORI)

Agency for Healthcare Research and Quality (AHRQ)

Defined Terms

  • Dissemination: the targeted distribution of information and intervention materials to a specific public health or clinical practice audience. The intent is to spread ("scale up") and sustain knowledge and the associated evidence-based interventions.
  • Implementation: the use of strategies to adopt and integrate evidence-based health interventions and change practice patterns within specific settings.
  • Pragmatic Trials: Pragmatic (or practical) trials are concerned with producing answers to questions faced by decision makers and relevant stakeholders. Pragmatic trials seek to increase the external validity of the findings while maintaining strong internal validity.

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