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University of Colorado Denver


Michael F. Wempe, PhD

Associate Research Professor, Department of Pharmaceutical Sciences and Director, Medicinal Chemistry Core Facility

Mailing address:

University of Colorado School of Pharmacy
Mail Stop C238
12850 E. Montview Blvd. V20-2105
Aurora, CO 80045

Office Location:

Pharmacy and Pharmaceutical Sciences Building (V20)
Second Floor
Room 2105

Lab Location:

Pharmacy and Pharmaceutical Sciences Building (V20)
Second Floor
Room 2410A


Training and Education:

  • BA, Hanover College; Hanover IN (Liberal Arts, Chemistry major)
  • MS Miami University, Oxford, Ohio, (Organic Chemistry)
  • PhD Miami University, Oxford, Ohio, (Organic Chemistry)
  • Post-Doctoral Fellow, University of Rochester Medical School, Rochester, NY (Pharmacology and
  • Physiology and Environmental Sciences (Toxicity)

Research Interests:

My laboratory uses chemical synthesis (organic and bio-organic) to produce known and novel compounds which are subsequently screened (in vitro) for their biological activity. Drug oral bioavailability may be influenced by low solubility, intrinsic instability, low membrane permeability, high first pass metabolism, and/or active excretion across the small intestine back into the intestinal lumen via efflux pumps.

Consequently, we are interested and conduct fundamental research in drug metabolism, pharmacokinetics, and toxicity. 'Research' activities include: i) Medicinal Chemistry - rational drug design and Structure-Activity Relationship (SAR) elucidation; ii) computational chemistry; iii) developing novel technology to improve drug oral bioavailability; and iv) identifying new bio-analytical methodology.