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University of Colorado Denver

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James R. Roede, PhD

Assistant Professor of Toxicology, Department of Pharmaceutical Sciences


James Roede
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Mailing address:

University of Colorado
Skaggs School of Pharmacy and Pharmaceutical Sciences
Mail Stop C238
12850 E. Montview Blvd. V20-2123
Aurora, CO 80045

Office Location:

Pharmacy and Pharmaceutical Sciences Building (V20)
2nd Floor
Room 2123

Lab Location:

Pharmacy and Pharmaceutical Sciences Building (V20)
2nd Floor
Room 2450G

Contact:

Training and Education:

  • BS, Michigan State University
  • PhD, University of Colorado (Advisor, Dennis R. Petersen)
  • Postdoctoral Fellow, Emory University (Mentor, Dean P. Jones)

Research Interests:

Overall strategy for research centerThe overall strategy of this research center is to capitalize on the growing concern regarding neurodegenerative diseases, like Parkinson’s disease and Alzheimer’s disease, and neurodevelopmental disorders, such as autism.  Due to a low incidence of these pathologies resulting from genetic alterations (5-10%), environmental causes of these diseases are investigated.  Specifically, elucidating the toxicologic mechanisms involved with complex mixtures.

Research plan:  The theme of my research program is the investigation of how an exposure to a single environmental agent, such as the fungicide maneb, augments the transport and cytotoxic properties of pharmaceuticals, dietary components, and/or chemicals arising from the environment or microbiome.  Elucidation of these mechanisms will help to prevent exacerbated toxicity due to alterations in gene expression resulting in enhanced transport of toxicants and xenobiotic interactions.  This mechanism may be directly relevant to neurodegenerative diseases like Parkinson’s disease and neurodevelopmental diseases like autism.  The aim of the laboratory is to utilize both targeted and systems approaches, such as proteomics, metabolomics and epigenomics, to investigate mechanisms of toxicity.  Some projects currently being conducted in the lab include the following: 

  • Project 1: Environmental causes of Parkinson’s disease – pesticide-mediated neurotoxicity.
  • Project 2: Environmental causes of autism – potentiation of Cd neurotoxicity by dithiocarbamate exposure.
  • Project 3:  Environmental causes of Alzheimer’s Disease.

Publications: