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Tobias Eckle, MD, PhD

Professor


  • Professional Activities
  • Research Interests
  • Publiciations
  •                                   Education:

    M.D., Eberhard-Karls University, Tübingen, Germany, 2001

    Ph.D., Eberhard-Karls University, Tübingen, Germany, 2001

    ​Professional Experience:​

    2016 - Present, Professor, Department of Anesthesiology, University of Colorado Denver

    2008 - Present, Director, Resident Training in Basic Science Research, University of Colorado Denver

    2007 - 2008, Assistant Professor, Department of Anesthesiology, University Hospital of Tübingen

    2006 - 2007, Clinical Fellow, Critical Care Medicine, University Hospital of Tübingen Germany

    2005 - 2006, Post Doctoral Fellowship, Department of Anesthesiology, University Hospital of Tübingen

    ​Current Research Support:

    1R01HL122472-01 (PI: Eckle)

    04/01/2015 – 03/31/2020

    NIH-NHLBI

    Intense Light Therapy for Perioperative Cardio-Protection
    The main goal of these studies is to define the contribution of intense light in cardiac tissue adaption to ischemia.

           ​Research Statement

    I am a physician scientist trained in anesthesiology, critical care medicine and cell biology. My research group is particularly interested in identifying cellular adaptive mechanisms to ischemia and hypoxia. During my postdoctoral fellowship, I established animal models of acute lung injury, myocardial ischemia and whole body hypoxia. Based on the huge variety of molecular biology techniques combined with a profound knowledge of sophisticated animal models, I offer unique training opportunities and thus successfully trained medical students, post docs, fellows and faculty within the last decade. Results from my current work have led to the identification of novel genes and new therapeutic concepts in the treatment of myocardial ischemia.

                    ​Selected Publiciations

    ​Eckle, T., L. Fullbier, M. Wehrmann, J. Khoury, M. Mittelbronn, J. Ibla, P. Rosenberger, and H.K. Eltzschig. 2007. Identification of Ectonucleotidases CD39 and CD73 in Innate Protection during Acute Lung Injury. J Immunol 178:8127-8137.

    Eckle T, Fuellbier L, Grenz, A and Eltzschig HK. 2008. Usefulness of pressure controlled ventilation at high inspiratory pressures to induce acute lung injury in mice. Am J Physiol Lung Cell Mol Physiol 295:L718-24.

    Eckle, T., T. Krahn, A. Grenz, D. Kohler, M. Mittelbronn, C. Ledent, M.A. Jacobson, H. Osswald, L.F. Thompson, K. Unertl, and H.K. Eltzschig. 2007. Cardioprotection by ecto-5'-nucleotidase (CD73) and A2B adenosine receptors. Circulation 115:1581-1590.

    Eckle T, Grenz, A, Laucher S, and Eltzschig HK. 2008. A2B adenosine receptor attenuates ventilator induced lung injury by enhancing alveolar fluid clearance. Journal of Clinical Investigation 118:3301-15. PMCID: PMC2532979

    Eckle T, Koeppen M, Eltzschig HK. 2009. Role of Extracellular Adenosine in Acute Lung Injury. Physiology. 24:298-306

    Eltzschig H, Eckle T. 2011. Ischemia and Reperfusion - From Mechanism to Translation. Nat Med. 17(11):1391-401. PMCID: PMC3886192.

    Eckle T, Hartmann K, Bonney S, Reithel S, Mittelbronn M, Walker LA, Lowes BD, Han J, Borchers CH, Buttrick PM, Kominsky DJ, Colgan SP and Eltzschig HK. 2012. Adora2b-elicited Per2 stabilization promotes a HIF-dependent metabolic switch crucial for myocardial adaptation to ischemia. Nat Med.18(5):774-82. PMCID: PMC3378044. 

    Koeppen, M, Harter PN, Bonney S, Bonney M, Reithel S, Zachskorn C, Mittelbronn M and Eckle T. 2012. Adora2b Signaling on Bone Marrow Derived Cells Dampens Myocardial Ischemia-reperfusion Injury. Anesthesiology.116(6):1245-57. PMCID: PMC3360806

    Eckle T, Brodsky K, Bonney M, Packard T, Han J, Borchers CH, Mariani TJ, Kominsky DJ, Mittelbronn M, Eltzschig HK. 2013. HIF1A reduces acute lung injury by optimizing carbohydrate metabolism in the alveolar epithelium. PLoS Biol. 11(9):e1001665. PMCID:PMC3782424

    Bonney S, Hughes K, Harter PN, Mittelbronn M, Walker L, Eckle T. 2013. Cardiac Period 2 in myocardial ischemia: Clinical implications of a light dependent protein. Int J Biochem Cell Biol. 45:667-71. PMCID: PMC3761885

    Bonney S, Kominsky, DJ, Brodsky K, Eltzschig HK, Walker L, Eckle T. 2013. Cardiac Per2 functions as novel link between fatty acid metabolism and myocardial inflammation during ischemia and reperfusion injury of the heart. PLoS One. 20;8(8):e71493. PMCID: PMC3748049

    Eckle, T., K. Hughes, H. Ehrentraut, K.S. Brodsky, P. Rosenberger, D.S. Choi, K. Ravid, T. Weng, Y. Xia, M.R. Blackburn, and H.K. Eltzschig. 2013. Crosstalk between the equilibrative nucleoside transporter ENT2 and alveolar Adora2b adenosine receptors dampens acute lung injury. FASEB J. PMCID: PMC3714574.

    Eckle, T., E.M. Kewley, K.S. Brodsky, E. Tak, S. Bonney, M. Gobel, D. Anderson, L.E. Glover, A.K. Riegel, S.P. Colgan, and H.K. Eltzschig. 2014. Identification of hypoxia-inducible factor HIF-1A as transcriptional regulator of the A2B adenosine receptor during acute lung injury. J Immunol .192:1249-1256. (PMCID: PMC3946986)

    Brainard J, Gobel M, Scott B, Koeppen M, Eckle T. 2015. Health Implications of Disrupted Circadian Rhythms and the Potential for Daylight as Therapy. Anesthesiology. May;122(5):1170-5. PMC in progress.

    Seo SW, Koeppen M, Bonney S, Gobel M, Thayer M, Harter PN, Ravid K, Eltzschig HK, Mittelbronn M, Walker L, Eckle T. 2015. Differential tissue-specific function of the Adora2b in cardio-protection. J Immunol. 195(4):1732-43. PMCID: PMC4576932