Skip to main content
Sign In
 

Faculty


The Crnic Institute supports a thriving community of investigators across the University of Colorado working together on a variety of projects to better understand Down syndrome. 


Basic cellular and molecular mechanisms of Down syndrome

​​Allen, Mary.jpeg
Mary Allen, PhD

​​Research Assistant Professor, BioFrontiers Institute​​

Transcriptional dysregulation and role of eRNAs in Down syndrome phenotypes​

Churchill, Mair.jpg

Mair Churchill, PhD

Professor, Pharmacology

Investigation of Chromatin Assembly Factor 1 B in Down syndrome neurons

DAlessandro, Angelo.jpg

Angelo D’Alessandro, PhD

Assistant Professor, Biochemistry and Molecular Genetics

Metabolic alterations of trisomy 21​

Dowell, Robin.jpg
Robin Dowell, PhD

Associate Professor, Molecular, Cellular, and Developmental Biology

Allele specific transcriptional and post-transcriptional regulation in Down syndrome

Gardiner, Katheleen.png

Katheleen Gardiner, PhD

Clinical Professor, Pediatrics

Exploring protein expression and its impact on cognition in Down syndrome

Maclean, Ken.jpeg
​Ken Maclean, PhD           

Professor, Pediatrics

ER stress, impaired proteostasis, autophagy, and lysosomal dysfunction in age-related cognitive decline in Down syndrome​​

Parker, Roy.jpg
​Roy Parker, PhD

Distinguished Professor, Biochemistry

White matter loss in Down syndrome: a consequence of altered protein biosynthesis?​​

Pearson, Chad.jpg
Chad Pearson, PhD

Assistant Professor, Cell and Developmental Biology

Ciliary trafficking defects and cerebellar hypoplasia in Down syndrome​

Roede, James.jpeg
James Roede, PhD

Assistan​t Professor, Pharmaceutical Sciences​

Altered neurogenesis and cognition in Down syndrome via the thiol redox proteome​

 
 

Neurological impacts of trisomy 21 and Alzheimer's disease

​​Bettcher, Brianne.jpg
Brianna Bettcher, PhD

Assistant Profe​​ssor, Neurosurgery

Inflammation-related cognitive and ​neuroanatomical bases of Down syndrome​​

Chen, Zhe.jpg
Zhe Chen, PhD

Assistant Research Professor, Molecular, Cellular, and Developmental Biology

Characterization of axon myelination in Down syndrome models

DellAcqua, Mark.png

Mark Dell’Acqua, PhD

Professor and Vice Chairman, Pharmacology

Amyloid beta postsynaptic signaling through anchored calcineurin​

Hoeffer, Charles.jpg

Charles Hoeffer, PhD

Assistant Professor, Integrated Physiology

Targeting dysregulated mitochondrial activity in DS-related Alzheimer's disease​

Jones, Kevin.jpg

Kevin Jones, PhD

Associate Professor, Molecular, Cellular, and Developmental Biology

BDNF augmentation as a therapeutic treatment for Down syndrome​

Macklin, Wendy.jpg

Wendy Macklin, PhD

Professor and Chair, Cell and Developmental Biology

The impact of trisomy on CNS myelination in Down syndrome model mice​

Maier, Steven.jpg

Steven Maier, PhD

Distinguished Professor, Psychology and Neuroscience

The role of microglia and neuroinflammation in cognitive alterations in Down syndrome​

Old, William.jpg


​William Old, PhD

Assistant Professor, Molecular, Cellular, and Developmental Biology

DYRK1A inhibitor mediated rescue of Down syndrome phenotypes in cerebral organoids​

Potter, Hunt.jpg
​Huntington Potter, PhD

Kurt N. and Edith von Kaulla Memorial Professor of Neurology

Studies aneuploidy and amyloid in Down syndrome Alzheimer's disease​

​Tamim Shaikh, PhD

Associate Professor, Pediatrics

Genetic modifiers of Autism Spectrum Disorders in patients with Down syndrome​​



Immunological impacts of trisomy 21 and interferon signaling

Burchill, Matthew.jpg

Matthew Burchill, PhD

Assi​stant Professor, Medicine – Gast​roenterology and Hepatology

The link between regulatory T cells and autoimmune disorders in Down syndrome​

Espinosa, Joaquin.jpg

​​Joaquin Espinosa, PhD

Professor, Pharmacology

Understanding Down syndrome as an interferonopathy

Hsieh, Elena.jpg
Elena Hsieh, MD

Assistant Professor, Immunology and Microbiology

Understanding the hyperactive interferon response in trisomy 21 at the single-cell level​

James, Stephanie.jpg
​Stephanie James, PhD

Assistant Professor, Pharmacy (Regis University)

Impact of trisomy 21 on B cell phenotype and function in adults​​

Janoff, Edward.jpeg
​Edward Janoff, MD

Professor, Medicine – Infectious Disease

Impact of trisomy 21 on B cell phenotype and function in adults​

Lenz, Laurel.jpg

​Laurel Lenz, PhD

Professor, Immunology and Microbiology 

Mechanisms responsible for increased type I IFN responses in trisomy 21

OConnor, Brian.jpg

​Brian O’Connor, PhD

Associate Professor, Immunology and Microbiology

Examining chromatin regulation of adaptive immune dysfunction in Down syndrome

Reinhardt, Lee.jpg

​Richard Lee ReinhardtPhD

Assistant Professor, Immunology and Microbiology

Mechanisms of reduced allergic susceptibility in Down syndrome

Shen, Jingshi.jpg

​Jingshi Shen, PhD

Associate Professor, Molecular, Cellular, and Developmental Biology

Does trisomy 21 cause dysregulation of cytotoxic lymphocyte-mediated cell killing?

Spritz, Richard.jpg

​Richard Spritz, MD 

Professor, Human Medical Genetics

Genetic analysis of autoimmunity in Down syndrome​

Sullivan, Kelly.jpg


​Kelly Sullivan, PhD

Assistant Professor, Pediatrics

Defining the impact of the interferon response on Down syndrome phenotypes

Tamburini, Beth.JPG

Beth Tamburini, PhD

Assistant Professor of Medicine and Immunology

Impact of immune dysregulation on liver function in Down syndrome​

 

Cancer, leukemia​, and safer treatments in Down syndrome

DeGregori, James.jpg
James DeGregori, P​hD

Professor, Biochemistry and Molecular Genetics

Causes and conseq​uences of altered DNA repair in Down syndrome

Hesselberth, Jay.jpg
Jay Hesselberth, PhD

Associate Professor, Biochemistry and Molecular Genetics

Causes and consequences of altered DNA repair in Down syndrome

Maloney, Kelly.jpg

Kelly Maloney, MD

Professor of Pediatrics – Heme/Onc and Bone Marrow Transplantation

Novel non-toxic therapeutic strategies for the treatment of leukemia Down syndrome

Pacenta, Holly.png

Holly Pacenta, MD

Physician, Pediatrics – Hematology/Oncology, UT Southwestern Medical Center

Novel non-toxic therapeutic strategies for the treatment of leukemia Down syndrome​

Pietras, Eric.JPG

Eric Pietras, PhD

Assistant Professor, Medicine – Hematology 

Interferons as a trigger of hematopoietic chemotoxicity following DS-ALL therapy​

Yi, Rui.jpg

Rui Yi, PhD

Assistant Professor, Molecular, Cellular, and Developmental Biology

Molecular mechanisms of miR-155 mediated leukemogenesis in Down syndrome​

 

Developmental and organ-specific impacts of trisomy 21

Benam, Kambez.jpg Kambez Benam, PhD

Assistant Professor, Medicine – Pulmonary Sciences and Criti​cal Care​

Microengineered a lung-on-a-chip to model Down syndrome airway pathophysiology​

Bilousova, Anya.jpg Ganna Bilousova, PhD

Assistant Professor, Dermatology

Exploring endothelial progenitor cell defects in Down syndrome​​​

Galambos, Csaba.jpg
Csaba Galambos, MD, PhD

Associate Professor, Pathology 

Overexpression of anti-angiogenic genes impairs lung development in Dp16 mice​

Klymkowsky, Michael.jpeg

Mike Klymkowsky, PhD

Professor, Molecular, Cellular, and Developmental Biology 

Inductive signaling in human iPSC-derived euploid and trisomic 21 cerebral organoids​

Mueller, Nick.jpg

Niklaus Mueller, PhD

Assistant Research Professor, Ophthalmology

Malformation of the ocular lens in Down syndrome visual impairment​

Petrash, Mark.jpg

Mark Petrash, PhD

Research Professor and Vice Chair of Research, Ophthalmology

Investigation of the cellular and molecular basis of vision defects in Down syndrome​

Song, Kunhua.jpeg Kunhua Song, PhD

Assistant Professor, Medicine – Cardiology

Using iPSC-derived cardiomyocytes to understand congenital heart defects in Down syndrome​

Vergara, Natalie.jpg Natalie Vergara, MD

Assistant Professor, Ophthalmology

Exploring retinal manifestations of Alzheimer’s disease in Down syndrome using iPSC-derived retinol organoids

Yeager, Michael.jpg

Michael Yeager, PhD

Clinical Associate Professor, Bioengineering

Lung immune environment and pneumonia infection in Down syndrome

​​