Skip Ribbon Commands
Skip to main content

Title

Determining the Originating Site of Rheumatoid Arthritis: Is It the Lung?

Project Description

​There is a preclinical period of systemic autoimmunity in rheumatiod arthritis (RA) prior to the onset of joint symptoms. This suggests RA is initiated outside of the joints, and our overall hypothesis is that the lung is the site of origination of autoimmunity in the development of RA. With this project, we will define baseline prevalence and longitudinal evolution of RA-related autoimmunity in the lung and circulation during the preclinical period of RA through autoantibody testing of simultaneously collected serum and induced sputum samples from arthritis-free subjects at-risk for future RA. We will also  determine immunologic mechanisms of RA-related autoantibody generation in the lung through   immunohistochemical staining of lung tissue in subjects with RA, arthritis-free subjects at-risk for future RA and non-RA controls.

Area of Study

Immunology and Autoimmune Diseases

Populations

Adults

Method

Clinical Imaging

Disease or Symptom

Arthritis; Immune Related Disease

Department

Medicine

Mentor Location

 

Mentor Contact Number

720-226-2412

Mentor Email

Kristen.Demoruelle@UCDenver.edu

Website

 

Mentor Name

Demoruelle, Kristen

Funding Department/Program

Medicine

Status

Current

Display on public listing?

Yes

Upload Date

 

Attachments

Created at 8/5/2018 1:07 PM by Hom, Patrick H
Last modified at 8/5/2018 1:07 PM by Hom, Patrick H