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Title

Defining and controlling pathogenic T cells in autoimmunity

Project Description

This project is to explore development of and potential treatment of autoimmune diseases. We focus on type 1 diabetes and MS predominantly, but are beginning to study the role of autoimmunity in atherosclerosis and cardio-vascular disease. We do translational and reverse translational work. That is, we study how immune cells work in mice and identify the counterparts in human subjects, including autoimmune subjects. We also explore human disease states and determine if we can reverse translate to create appropriate mouse models for further study. The lab has generated a unique drug to control autoimmune inflammation and we are exploring how this drug may translate to T1D, MS and CVD.

Area of Study

Cardiovascular; Immunology and Autoimmune Diseases

Populations

 

Method

Animal Models; Biomolecular Structure and Biochemistry; Cell Biology, Molecular Biology, and Genetics; Chart Review; Neuroimaging

Disease or Symptom

COPD; Diabetes; Immune Related Disease; Multiple Sclerosis

Department

Medicine

Mentor Location

12850 East Montview Blvd

Mentor Contact Number

303-724-4787

Mentor Email

david.wagner@ucdenver.edu

Website

 

Mentor Name

Wagner, David

Funding Department/Program

Medicine

Status

Current

Display on public listing?

Yes

Upload Date

8/26/2015 1:11 PM

Attachments

Created at 8/26/2015 4:12 PM by Ross, Randy
Last modified at 8/25/2017 10:54 PM by Macfarlane, Helen