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Title

mTOR Inhibitors in Transplantation and Cancer

Project Description

The inhibitors of the mammalian target of rapamycin (mTOR) pathway are proliferation inhibitors and as such used as immunosuppressants in transplantation, as anticancer agents and on drug-eluting coronary stents. Clinically used mTOR inhibotors are Sirolimus, Everolimus and Zotarolimus. These have a very complex drug metabolism with many of these metabolites raching significant concentrations in blood. Interestingly, the anti-proliferative and other biological activities of these metabolites are mostly unknown. This project will isolate the major metabolites. Their structures will be identified and their biological activities will be tested.

Area of Study

Cardiovascular; Immunology and Autoimmune Diseases; Pharmacology and Physiology

Populations

 

Method

Biomolecular Structure and Biochemistry; Cell Biology, Molecular Biology, and Genetics

Disease or Symptom

Cancer; Heart Disease

Department

Anesthesiology

Mentor Location

Bioscience 2, Suite 200 12705 East Montview Boulevard Aurora, CO 80045-7109

Mentor Contact Number

303-7245-665

Mentor Email

uwe.christians@ucdenver.edu

Website

http://www.bioanalytics.us

Mentor Name

Christians, Uwe

Funding Department/Program

Anesthesiology

Status

Current

Display on public listing?

Yes

Upload Date

 

Attachments

Created at 8/21/2015 9:08 PM by Ross, Randy
Last modified at 8/14/2019 12:39 PM by Zoghby, Caitlin