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Title

Elucidating the effects of secreted mucins on breast cancer biology

Project Description

My laboratory focuses on the role of estrogen and progesterone receptors in breast cancer biology. Specifically we are interested in estrogen receptor positive breast tumors that secrete mucins. Mucins are high molecular weight, multifunctional glycoproteins that are components of mucus. There are two classes of mucins: membrane-bound and secreted/gel-forming mucins. We study how gel forming mucins that are expressed in some breast carcinomas and in invasive breast cancers regulate tumor biology. We also study estrogen receptor mediated regulation of secreted mucins. Our laboratory has developed two novel breast cancer cell lines that secrete mucin. These new cell lines are used to examine the effects of mucin production and secretion on breast cancer cell biology.

Area of Study

Hematology and Oncology

Populations

Women

Method

Cell Biology, Molecular Biology, and Genetics

Disease or Symptom

Cancer

Department

Medicine

Mentor Location

RC1 North, P18-5122 12800 E 19th Ave

Mentor Contact Number

303 724-3939

Mentor Email

britta.jacobsen@ucdenver.edu

Website

 

Mentor Name

Jacobsen, Britta

Funding Department/Program

Cancer Center; Medicine

Status

Current

Display on public listing?

Yes

Upload Date

 

Attachments

Created at 8/20/2015 10:14 AM by Miller, Michael
Last modified at 8/14/2019 12:46 PM by Zoghby, Caitlin