Schizophrenia Research Faculty
Robert Freedman, MD
Laura Martin, MD
Don Rojas, PhD
Jason Tregellas, PhD
Invesigators at the Brain Imaging Center are interested in several aspects of neuropathology in schizophrenia, including inhibitory dysfuction, the involvement of the cholinergic system, and auditory processing.
Inhibitory Dysfuction and Involvement of Cholinergic Systems
Inhibitory dysfunction is thought to be a core feature of schizophrenia. Our lab currently is studying frequently observed deficits thought to reflect problems in inhibitory processes at the neuronal level.
I. Sensory Gating Deficits
People with schizophrenia are often unable to ignore or filter out unimportant information in the environment. This "sensory gating" deficit may be related to disease pathology. Although this deficit has been well studied over the last two decades using electroencephalography (EEG), we still do not understand which brain regions are involved in this process. To determine which parts of the brain are involved, we have developed a measure of sensory gating compatible with functional magnetic resonance imaging (fMRI). Intriguing new results from the first round of this study will be available here in 2007.