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Hematology, Oncology and BMT - Research

Overview and Faculty Research Interests


Children’s Hospital Colorado Center for Cancer and Blood Disorders (CCBD) includes physician faculty members with a variety of interests in clinical, translational (“bench to bedside”), and laboratory research. Faculty members published over 200 scientific articles in the past five years and have grant funding from major national agencies including the National Institutes of Health, National Cancer Institute, American Cancer Society, Leukemia and Lymphoma Society, the Centers for Disease Control, and the Maternal and Child Health Bureau.

Major areas of clinical research focus include trials for children with all types of cancer, development of new cancer therapies, sickle cell disease, hemophilia and clotting disorders, methods of redirecting the immune system to cancer and studies of different modes of bone marrow transplantation.

Translational and basic laboratory research programs include studies of leukemia and brain tumor biology and genetics, development of new molecularly targeted therapies for various types of cancer, genetic studies of von Willebrand disease and other bleeding disorders, white blood cell development and function, immunotherapy with T cells and NK cells, methods to reduce graft vs. host disease and studies that seek to understand why reactions occur to blood transfusions.

The faculty members of the CCBD include internationally recognized leaders in research in hemophilia and clotting disorders (Drs. Marilyn Manco-Johnson and Jorge Di Paola), white blood cell function (Dr. Daniel Ambruso), transfusion reactions (Dr. Christopher Silliman), brain tumors (Drs. Nicholas Foreman and Rajeev Vibhakar), experimental therapeutics (Dr. Lia Gore) leukemia biology and treatment (Dr. Kelly Maloney), and bone marrow transplant (Drs. Roger Giller and Michael Verneris).

Some of our faculty have created websites for their research labs. To learn more, view the research labs directory​.​