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Appel Lab



The long-term goal of the Appel laboratory is to understand how the nervous system develops and how developmental abnormalities cause neurological disorders that affect children. In particular, lab members focus their investigations on mechanisms that produce neurons and glial cells from neural progenitor and stem cells and regulate myelination in response to brain activity.

Link to Appel Website

HudishLaura resized.jpg Caleb Doll, Ph.D., Research Assistant Professor
Research Project: Fragile X Syndrome and myelination

KearnsChristina (17) - resized.jpg
Christina Kearns, M.S., Senior Professional Research Assistant
Research Project: Neural progenitor specification for glial fate.
MathewsEmily resized.jpg
Karlie Fedder, B.S., Graduate Student
Research Project: Activity regulated mechanisms of myelination
RavanelliAndrew resized.jpg
Alex Hughes, B.S., Graduate Student
Research Project: Axo-glial synaptic communication.
MathewsEmily resized.jpg
Kayt Scott, B.S., Graduate Student
Research Project: Mechanisms of neural progenitor fate specification.
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Katie Yergert, B.S., Graduate Student
Research Project: Activity regulated mRNA transport and translation in oligodendrocytes.

 

Link to PubMed publications (https://www.ncbi.nlm.nih.gov/pubmed/?term=Appel%20B+zebrafish​)


Selected Publication

Mathews, E.S. and Appel, B. (2016) Cholesterol biosynthesis supports myelin gene expression and axon ensheathment through modulation of PI3K/Akt/mTor Signaling. Journal of Neuroscience 36(29):7628-39. PMID: 27445141.

Hudish, L.I., Galati, D.F., Ravanelli, A.M., Pearson, C.G., Huang, P. and Appel, B. (2016) miR-219 regulates neural progenitors by dampening apical Par protein-dependent Hedgehog signaling. Development 143(13):2292-304. PMID: 27226318.

Ravanelli AM, Appel B. (2015) Motor neurons and oligodendrocytes arise from distinct cell lineages by progenitor recruitment. Genes & Development 29:2504-2515. PMCID: PMC4691953.

Kearns CA, Ravanelli AM, Cooper K, Appel B. (2015) Fbxw7 Limits Myelination by Inhibiting mTOR Signaling. Journal of Neuroscience 35(44):14861-71. PMCID: PMC4635133.

Hines JH, Ravanelli AM, Schwindt R, Scott EK, Appel B. (2015) Neuronal activity biases axon selection for myelination in vivo. Nature Neuroscience 18(5):683-9. PMCID: PMC4414883​.

Mathews, E.S., Mawdsley, D.J., Walker, M., Hines, J.H., Pozzoli, M. and Appel, B. (2014) Mutation of Hmg-CoA Synthase I reveals requirements for isoprenoid and cholesterol synthesis in oligodendrocyte migration arrest, axon wrapping and myelin gene expression. Journal of Neuroscience 26, 3402-3412. PMCID: PMC3935092.

Hudish, L.I., Blasky, A. and Appel, B. (2013) miR-219 regulates neural precursor differentiation by direct inhibition of apical Par polarity proteins. Developmental Cell 27, 387-398. PMID: 24239515.

Snyder JL, Kearns CA, Appel B (2012) Fbxw7 regulates Notch to control specification of neural precursors for oligodendrocyte fate. Neural Dev. May 3;7:15. PMID: 22554084.

Kucenas S, Wang WD, Knapik EW, Appel B (2009) A selective glial barrier at motor axon exit points prevents oligodendrocyte migration from the spinal cord. J Neurosci. Dec 2;29(48):15187-94. PMID:19955371

Zannino DA, Appel B (2009) Olig2+ precursors produce abducens motor neurons and oligodendrocytes in the zebrafish hindbrain. J Neurosci. Feb 25;29(8):2322-33. PMID:19244509

Kucenas, S., Takada, N., Park, H.C., Woodruff, E., Broadie, K. and Appel, B. (2008) CNS-derived glia ensheath peripheral nerves and mediate motor root development. Nature Neuroscience 11, 143-151.

Shin, J., Poling, J., Park, H.C. and Appel, B. (2007) Notch signaling regulates neural precursor allocation and binary neuronal fate decisions in zebrafish. Development 134, 1911-1920.

Park, H.C., Roberts, R., Shin, J. and Appel, B. (2007) An olig2 reporter gene marks oligodendroycte precursors in postembryonic spinal cord of zebrafish. Developmental Dynamics 236, 3402-3407.

Latimer, A.J. and Appel, B. (2006) Notch signaling regulates midline cell specification and proliferation in zebrafish. Developmental Biology 298, 392-402.

Kirby, B., Takada, N., Latimer, A.J., Shin, J. and Appel, B. (2006) In vivo imaging shows dynamic oligodendrocyte progenitor behavior during zebrafish development. Nature Neuroscience 9, 1506-1511.

Park, H.-C., Boyce, J., Shin, J. and Appel, B. (2005) Oligodendrocyte specification in zebrafish requires Notch-regulated cyclin-dependent kinase inhibitor function. Journal of Neuroscience 25, 6836-6844.

Park, H-C., Shin, J. and Appel, B. (2004) Spatial and temporal regulation of ventral spinal cord precursor specification by Hedgehog signaling. Development 131, 5959-5969.

Park, H.-C. and Appel, B. (2003) Delta-Notch signaling regulates oligodendrocyte specification. Development 130, 3747-3755.

Park, H.-C., Mehta, A., Richardson, J, and Appel, B. (2002) olig2 is required for zebrafish primary motor neuron and oligodendrocyte development. Developmental Biology 248, 356-368.