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Basic Research

in the Department of OB/Gyn


 

Disorders of the reproductive system can have a lifelong impact on the health of women and their offspring.  The Division of Basic Reproductive Sciences is dedicated to furthering understanding of reproductive biology and women’s cancers by investigating reproductive function at the molecular, cellular and organismic levels and to fostering educational development of basic and clinical scientists in the areas of reproductive biology, obstetrics and gynecology, and women's health in general. 

Research opportunities within the Division include projects related to molecular and cellular biology of breast, endometrial and ovarian cancers; developmental regulation of placental and mammary gland functions; effects of obesity on reproductive functions; biomechanical properties of reproductive organs; hormonal regulation of menarche and menopause; and disorders of pregnancy. 

 

Our Faculty are currently involved in the following research and studies:

 

Kian Behbakht, M.D., Associate Professor

  • Homeobox genes in ovarian cancer
  • Novel therapeutics for gynecologic malignancies

 

Andrew P. Bradford, Ph.D., Associate Professor

  • Signal Transduction Pathways regulating Endometrial (uterine) cancer
  • Biomarkers and novel therapeutics in uterine malignancies
  • Uterine Fibroids (leiomyoma) and sarcomas (leiomyosarcoma)  

 

Twila A. Jackson, Ph.D., Assistant Professor

  • Estrogen receptor signaling in endometrial tumors
  • Estrogen regulation of the PTEN tumor suppressor

 

James L. McManaman, Ph.D.,  Professor and Chief

  • Mechanisms of lipid secretion in lactation
  • Mammary Gland Development
  • Biomarkers of preterm labor

 

Margaret (Peggy) Neville, Ph.D. Professor Emeritus

  • Mammary gland development and lactation
  • Gene array analysis

 

 

'There are in fact two things, science and opinion; the former begets knowledge, the latter ignorance'

Hippocrates