We are currently seeking physically active women and men
for a research study on
PTH and Calcium Responses to Exercise (PACE) in Older Adults
Goal of the study: PACE Sr. is studying how the changes in blood calcium during exercise impact the bone
response to exercise. Generally, exercise is good for bone health. However, some
studies have shown that older adults do not always get the bone gains that we expect
from exercise. This may happen because exercise causes calcium loss through the
sweat. These losses go along with declines in blood calcium and increases in
parathyroid hormone (PTH). PTH is the hormone that causes calcium to be released
from bone. It is possible that the reduced bone gains in people who exercise a lot is
related to this calcium loss during exercise. This study will study whether the amount of
calcium lost through the sweat during exercise impacts blood calcium and markers of
Outline of the study: The PACE Sr. EXP1 study includes two 1 hour vigorous walking sessions on a treadmill.
After a pre-exercise meal with a known amount of calories and calcium, the exercise
sessions will be done in either a warm (~80°) or a cool (~60°) room. The temperature for
these sessions will be in random order and will be 1 month apart. The study will be held
on the University of Colorado Anschutz Medical Campus.
Eligibility: To participate, you must be...
- A woman or man in generally good health, age 60 - 80
- Regularly walk for exercise and can walk for an hour at a time
- Not taking medication for osteoporosis
- No history of Diabetes or Cardiovascular Disease
Benefits: Eligible volunteers will recieve at no cost...
- Information on their VO2 max (aerobic fitness)
- Information on their body composition and bone density
- Physical exam and basic blood chemistries
Volunteers will have a physical exam, bone density test, treadmill test, and blood tests to
determine if they are eligible. These tests will be done at no charge. Volunteers will be
compensated for their time.
Sarah Wherry, PhD, is the Principal Investigator of the PACE study. This study is funded
through the Colorado Clinical and Translational Sciences Institute (CCTSI) and the
Nutrition and Obesity Research Center. It is approved by the Colorado Multiple
Institutional Review Board (protocol #15-0250).
If you are interested in participating in the PACE study, please contact Toby Wellington at 720-848-6376 or