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Kristen Demoruelle, MD

Assistant Professor of Medicine


Dr. Kristen Demoruelle is Assistant Professor of Medicine at the University of Colorado School of Medicine in the Division of Rheumatology.
 
Her primary research interest is in rheumatoid arthritis (RA) with a specific focus on translational research studies that investigate the development of RA-related autoimmunity prior to the onset of joint disease in RA during a period of development known as the ‘preclinical’ period. She is particularly interested in understanding the site where and mechanisms by which RA-related autoimmunity initially develops and sex differences influencing this process.  Dr. Demoruelle has published multiple manuscripts and review articles in this area. Ultimately, her research goals are to develop novel site-specific and mechanism-specific prevention strategies that abrogate RA at the site of initial immune dysregulation.

8/1999-6/2003               B.S. Biochemistry, Delta State University, Cleveland, MS
 
8/2003-5/2007               M.D. University of Mississippi School of Medicine, Jackson, MS 
 
6/2007-7/2010               Intern and Resident, Internal Medicine, University of Colorado
                                         School of  Medicine, Aurora, CO

7/2010-7/2013               Fellow, Division of Rheumatology, University of Colorado
                                         School ofMedicine, Aurora, CO
7/2013-6/2014        Instructor of Medicine, Department of Medicine, Division of Rheumatology,
                                 University of Colorado School of Medicine, Aurora, CO
 
6/2014- present      Assistant Professor of Medicine, Department of Medicine, Division of
                                 Rheumatology, University of Colorado School of Medicine, Aurora, CO

PROFESSIONAL ORGANIZATIONS/MEMBERSHIPS
2007-2011           Member, American College of Physicians
2010-present       Member, American College of Rheumatology
2012-present       Member, American Federation for Medical Research
2012-2013           Member, International Society for Clinical Densitometry
 
MAJOR COMMITTEE AND SERVICE RESPONSIBILITIES
2011-present       Member, Intern Selection Committee, University of Colorado School of 
                             Medicine, Internal Medicine Residency Program
2015-present       Member, Colorado Clinical & Translational Sciences Institute (CCTSI)
                             Scientific Advisory & Review Committee (SARC)

2012         Travel Award, American College of Rheumatology, to attend the European
                Workshop for Rheumatology Research, Stockholm, Sweden
 
2012         American Federation for Medical Research WAFMR/Centocor Scholar Award
 
2012         American College of Rheumatology Knowledge Bowl, championship team member
 
2012         Faculty of 1000 Recommended Article for “Airways abnormalities and rheumatoid
                arthritis-related autoantibodies in subjects without arthritis: Early injury or initiating
                site of autoimmunity”

2013         American College of Rheumatology Distinguished Fellow Award
 
2014         Travel Award, Western Society for Clinical Investigation, to attend the American
                Federation for Medical Research Western Regional Meeting, Carmel, CA
 
2014         Poster Award, CU Women’s Health Research Day
 
2015         Medical Student Research Preceptorship Award, Rheumatology Research Foundation
 
2015         University of Colorado Department of Medicine Rising Star Award
                This award recognizes outstanding junior faculty members who exemplify the   
                department’s core values of excellence in research, clinical work, education, and 
                community service.

Dr. Demoruelle’s translational research aims to understand the earliest steps of RA development, specifically the development of RA-related autoimmunity prior to the onset of joint disease during a period of development known as the ‘preclinical’ period of RA. She has a particular interest in understanding the site where and mechanisms by which RA-related autoimmunity initially develops and sex differences influencing this process. Her research investigates the central hypothesis that RA-related autoimmunity is initially generated at a mucosal surface and related to specific environmental factors such as microbiota. Her research focuses on two main potential sites that are likely involved in the generation of autoimmunity in RA - the lung and female genital tract mucosa. Ultimately, her research goals are to develop novel prevention strategies that abrogate RA at the site of initial immune dysregulation.
 
Peer reviewed publications:
1. Demoruelle MK, Deane KD. Antibodies to citrullinated protein antigens (ACPAs): clinical and pathophysiologic significance.  Current Rheumatology Reports. 2011 Oct;13(5):421-30. PMC4095867
 
2. Demoruelle MK, Weisman M, Simonian P, Lynch DA, Sachs P, Pedraza I, Harrington A, Kolfenback J, Striebich C, Pham Q, Strickland C, Petersen M, Parish M, Derber L, Norris JM, Holers VM, Deane KD.  Brief Report: Airways abnormalities and rheumatoid arthritis-related autoantibodies in subjects without arthritis: Early injury or initiating site of autoimmunity?  Arthritis & Rheumatism. 2012 Jun;64(6):1756-61.  PMC3319006
 
3. Demoruelle MK, Deane KD. Treatment strategies in early rheumatoid arthritis and prevention of rheumatoid arthritis. Current Rheumatology Reports. 2012 Oct;14(5):472-80. PMC3616381
 
4. Demoruelle MK, Kahr A, Verilhac K, Deane KD, Fischer A, West S. Recent-onset systemic lupus erythematosus complicated by acute respiratory failure. Arthritis Care & Research. 2013 Feb;65(2):314-23.
 
5. Demoruelle MK, Parish M, Derber L, Kolfenbach J, Hughes-Austin J, Weisman M, Gilliland W, Edison J, Buckner J, Mikuls T, O’Dell J, Keating R, Gregersen P, Norris JM, Holers VM, Deane KD. Anti-cyclic citrullinated peptide assays differ in subjects at elevated risk for future rheumatoid arthritis and subjects with established disease. Arthritis & Rheumatism. 2013 Sep;65(9):2243-52. PMC3776020.
 
6. Willis VC*, Demoruelle MK*, Derber L, Chartier-Logan C, Parish M, Pedraza I, Weisman M, Norris JM, Holers VM, Deane KD. *co-first author. Sputum autoantibodies in patients with established rheumatoid arthritis and subjects at-risk for future clinically apparent disease. Arthritis & Rheumatism. 2013 Oct;65(10):2545-54. PMC4066465.
 
7. Gan RW, Deane KD, Zerbe GO, Demoruelle MK, Weisman MH, Buckner JH, Gregersen PK, Mikuls TR, O’Dell JR, Keating RM, Holers VM, Norris JM. Relationship between air pollution and positivity of RA-related autoantibodies in individuals without established RA: a report on SERA. Annals of Rheumatic Disease. 2013 Dec 1;72(12):2002-5. PMC3818364.
 
8. Demoruelle MK, Deane KD, Holers VM. When and where does inflammation begin in rheumatoid arthritis? Current Opinion in Rheumatology. 2014Jan;26(1):64-71. PMC4033623
 
9. Demoruelle MK, Solomon JJ, Fischer A, Deane KD. The Lung May Play a Role in the Pathogenesis of Rheumatoid Arthritis. International Journal of Clinical Rheumatology. 2014 Jun;9(3): 295-309. PMC4469280
 
10. Kuhn KA, Pedraza I, Demoruelle MK. Mucosal immune responses to microbiota in the development of autoimmune disease. Rheumatic Disease Clinics of North America. 2014 Sept; 40(4): 711-725.
 
11. Gan RW, Trouw LA, Shi J, Toes RE, Huizinga TW, Demoruelle MK, Kolfenbach JR, Zerbe GO, Deane KD, Edison JD, Gilliland WR, Norris JM, Holers VM. Anti-carbamylated protein antibodies are present prior to, and are associated with the future diagnosis of rheumatoid arthritis. Journal of Rheumatology. 2015 Apr;42(4):572-9. PMC4383711
 
 
Publications (NCBI publication list)
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