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Publications


Our physicians are internationally known for their research. The following is a sampling of their publications:

Richard Albert, M.D.

Albert, RK, Hubmayr, RD. The prone position eliminates compression of the lungs by the heart. Am J Respir Crit Care Med 2000; 161: 1660-5.

Albert, RK. Prone Ventilation. In: Acute Respiratory Distress Syndrome. Clinics in Chest Medicine 2000; 21: 511-17.

Albert, RK, Spiro, S, Jett, J. Comprehensive Respiratory Medicine. Mosby, London and Philadelphia, 1999, Reprinted, 2001

David Badesch, M.D.

Barst RJ, Rubin LJ, Long WA, McGoon MD, Rich S, Badesch DB, Groves BM, Tapson VF, Bourge RC, Brundage BH, Koerner SK, Langleben D, Keller CA, Murali S, Uretsky BF, Clayton LM, Jobsis MM, Blackburn SD, Shortino D, Crow JW, for the Primary Pulmonary Hypertension Study Group. A comparison of continuous intravenous epoprostenol (prostacyclin) with conventional therapy for primary pulmonary hypertension. NEJM 334:296-301;1996.

Badesch DB, Tapson VF, McGoon MD, Brundage BH, LJ Rubin, Wigley FM, Rich S, Barst RJ, et al. Continuous intravenous epoprostenol for pulmonary hypertension due to the scleroderma spectrum of disease. A randomized controlled trial. Annals of Internal Medicine 132:425-434;2000.

Channick, RN, Simonneau G, Sitbon O, Robbins IM, Frost A, Tapson VF, Badesch DB, Roux S, Rainisio M, Bodin F, Rubin LJ. Effects of the dual endothelin receptor antagonist bosentan in patients with pulmonary hypertension: A randomized placebo-controlled study. Lancet 358:1119-23;2001.

Russell P. Bowler

Bowler, R.P., J. Arcaroli, J.D. Crapo, A. Ross, J.W. Slot, and E. Abraham, Extracellular superoxide dismutase attenuates lung injury after hemorrhage. Am J Respir Crit Care Med, 2001. 164(2): p. 290-4.

Pineda, J.A., M. Aono, H. Sheng, J. Lynch, J.C. Wellons, D.T. Laskowitz, R.D. Pearlstein, R. Bowler, J. Crapo, and D.S. Warner, Extracellular superoxide dismutase overexpression improves behavioral outcome from closed head injury in the mouse. J Neurotrauma, 2001. 18(6): p. 625-34.

Bowler, R. P., Nicks, M, Warnick, K, Crapo, JD. The role of extracellular superoxide dismutase in bleomycin induced pulmonary fibrosis. AJP. (April - in press)

Russell P. Bowler, Mike Nicks, Ida.B Thøgersen, Zuzana Valnickova, Peter Højrup, Alex Franzusoff, Jan J Enghild, James D. Crapo. Furin proteolytically processes the heparin binding region of extracellular superoxide dismutase. JBC (submitted)

Russell P. Bowler, Mike Nicks, Ida.B Thøgersen, Zuzana Valnickova, Peter Højrup, Alex Franzusoff, Jan J Enghild, James D. Crapo. A catalytic antioxidant (AEOL 10150) attenuates changes in expression of inflammatory genes in a mouse model of stroke (submitted)

Reuben Cherniack, M.D.

Cherniack, R.M., Colby, T.V., Flint, A., Thurlbeck, W.M., Waldron, J.A., Ackerson, L., Schwarz, M.I., King, T.E., Jr. Correlation of structure and function in idiopathic pulmonary fibrosis. Am J Respir Crit Care Med 151:1180-1188, 1995.

Drazen J.M., Israel, E., Cherniack, R.M.,and ACRN. Comparison of regularly scheduled versus "as needed only" use of albuterol in mild asthma. N Engl J Med 335:841-847, 1996

King, TE., Jr., Schwarz, MI., Brown,KK, Tooze JA, Colby, T.V., Waldron, J.A., Flint, A., Thurlbeck, W.M., and Cherniack, R.M., Idiopathic Pulmonary Fibrosis: Relation Between Histopathologic Features and Mortality Am J Resp Crit Care Med 164:1025-1032, 2001

Hong Wei Chu, M.D.

Chu HW, Halliday JL, Martin RJ, Leung DYM, Szefler SF and Wenzel SE. Collagen deposition in large airways may not differentiate severe asthma from milder forms of the disease. Am J Respir Crit Care Med 1998; 158: 1936-1944.

Chu HW, Kraft M, Krause JE, Rex MD and Martin RJ. Substance P and its receptor neurokinin-1 expression in asthmatic airways. J Allergy Clin Immunol 2000; 106:713-722.

Chu HW, Balzar S, Trudeau JB and Wenzel SE. Peripheral blood and airway tissue expression of TGF-b by neutrophils in asthmatic subjects and normal control subjects. J Clin Allergy Clin Immunol 2000; 106:1115-1123.

Martin RJ, Chu HW, Honour JM and Harbeck RJ. Airway inflammation and bronchial hyperresponsiveness after Mycoplasma pneumoniae infection in a murine model. Am J Respir Cell Mol Biol 2001; 24:577-582.

Chu HW, Kraft M, Rex MD and Martin RJ. Evaluation of blood vessels and edema in asthmatic airways - regulation with clarithromycin treatment. Chest 2001; 120:416-422.

James D. Crapo, M.D.

Vlahovic G, ML Russell, RR Mercer and JD Crapo. Cellular and connective tissue changes in alveolar septal walls in emphysema. Am J Respir Crit Care Med 160:2086-2092, 1999.

Enghild JJ, IB Thogersen, TD Oury, Z Valnickova, P Hojrup and JD Crapo. The heparin-binding domain of extracellular superoxide dismutase is proteolytically processed intracellularly during biosynthesis. J Biol Chem 274:14818-14822, 1999.

Day BJ, I Batinic-Haberle and JD Crapo. Metalloporphyrins are potent inhibitors of lipid peroxidation. Free Radic Biol Med 26:730-736, 1999.

Levin ED, TC Brady, EC Hochrein, TD Oury, LM Jonsson, SL Marklund and JD Crapo. Molecular manipulations of extracellular superoxide dismutase: functional importance for learning. Behavior Genetics 28:381-390, 1998.

Ho YS, R Vincent, MS Dey, JW Slot and JD Crapo. Transgenic models for the study of lung antioxidant defense: enhanced manganese-containing superoxide dismutase activity gives partial protection to B6C3 hybrid mice exposed to hyperoxia. Respir Cell Mol Biol 18:538-547, 1998.

Brian Day, Ph.D.

Day, B.J., Patel, M., Calavetta, L., Chang, L.Y. and Stamler, J.S. A mechanism for paraquat toxicity that involves nitric oxide synthase. Proc. Natl. Acad. Sci. 96:12760-12765, 1999.

Milano, J. and Day, B.J. A catalytic antioxidant metalloporphyrin blocks hydrogen peroxide induced mitochondrial DNA damage. Nucleic Acid Res. 28:968-973, 2000.

Velsor, L., van Heeckeran, A., and Day, B.J. Antioxidant imbalance in the lungs of the cystic fibrosis transmembrane conductance regulator protein mutant mouse. Am. J. Physiol. 281:L31-L38, 2001.

Kachadourian, R., Liochev, S.I., Cabelli, D.E., Patel, M., Fridovich, I., and Day, B.J. 2-Methoxyestradiol (2-ME) does not inhibit superoxide dismutase. Arch. Biochem. Biophys. 392:349-353, 2001.

Oury, T.D., Thakker, K., Chang, L.Y., Crapo, J.D. and Day, B.J. Attenuation of bleomycin-induced pulmonary fibrosis by a catalytic antioxidant metalloporphyrin. Am. J. Respir. Cell Mol. Biol. 25:164-169, 2001.

James Fisher, M.D.

Chen Y-Q, Fisher JH, Wang M-H. Activation of the RON receptor tyrosine kinase inhibits educible nitric oxide synthase expression by murine peritoneal exudate macrophages. J Immunol 16199):4950-9, 1998.

Korfhagen TR, Sheftelyevich V, Burhans MS, Bruno MD, Wert SE, Stahlman MT, Jobe AH, Ikegami M, Whitsett JA, Fisher JH. Surfactant protein-D regulates pulmonary surfactant homeostasis J. Biol. Chemistry 273(43):28438-43, 1998.

Fisher JH, Sheftelyevich V, Ye-Shih Ho, Fligiel S, McCormack FX, Korfhagen TR, Whitsett JA, Ikegami MI. Pulmonary Specific Expression of SP-D Corrects Pulmonary Lipid Accumulation In SP-D Gene Targeted Mice. Am J Physiol Lung Cell Mol Physiol 278 (2): L365-73, 2000

Andrew Fontenot, M.D.

Fontenot AP, Falta MT, Freed BM, Newman LS, Kotzin BL. Identification of pathogenic T cells in patients with beryllium-induced lung disease. J. Immunol. 1999; 163: 1019-1026.

Fontenot AP, Vollmer M, Newman LS, Kotzin BL. HLA-DP restriction of CD4+ T Cells from the lungs of patients with beryllium-induced lung disease. Proc. Natl Acad Med. USA 2000; 97:12717-12722.

Fontenot AP, Newman LS, Kotzin BL. Chronic beryllium disease: T cell recognition of a metal presented by HLA-DP. Clin Immunol 2001;100:4-14.

Fontenot AP, Maier LA, Canavera SJ, Barker E, Boguniewicz M, Newman LS, Kotzin BL. The Use of Beryllium Skin Patch Testing as an In Vivo Model of Granulomatous Lung Disease. J Immunol: in press.

Janet Henson, M.D.

Renz H, Smith HR, Henson JE, Ray BS, Irvin CG and Gelfand EW. Aerosolized antigen exposure without adjuvant causes increased IgE production and increased airway responsiveness in the mouse. J. Allergy Clin. Immunol. 89:1127-1138, 1992.

Martin RJ, Boguniewicz M, Henson JE, Cehniker AC, Williams M, Giorno RC and Leung DYM. The effects of inhaled interferon gamma in normal human airways. Am. Rev. Respir. Dis. 148:1677-1682, 1993.

Kraft M, Cassell GH, Henson JE, Watson H , Williamson J ,Marmion BP , Gaydos CA , and Martin RJ . Detection of Mycoplasma pneumoniae in the airways of adults with chronic asthma. Am. J. .Respir. Crit. Care Med. 158 :998-1001, 1998.

Kench JA, Russell DM, Fadok VA ,Young SK, Worthen GS, Jones- Carson J, Henson JE, Henson PM, and Nemazee D. Aberrant wound healing and TGF beta production in the autoimmune- prone MRL/ + mouse. Clin. Immunol.. 92 : 300-310, 1999.

Peter Henson, M.D.

Fadok VA, Bratton DL, Rose D, Pearson A, Ezekowitz A, Henson PM. A receptor for phosphatidylserine-specific clearance of apoptotic cells. Nature 405:85-90, 2000.

Hoffmann PR, deCathelineau AM, Ogden CA, Leverrier Y, Bratton DL, Daleke DL, Ridley AJ, Fadok VA, Henson PM. Phosphatidylserine (PS) induces PS receptor-mediated macropinocytosis and promotes clearance of apoptotic cells. J Cell Biol 155(4):649-659, 2001.

Ogden CA, deCathelineau A, Hoffmann PR, Fadok VA, Bratton D, Henson PM. C1q and collectin engagement of cell surface calreticulin initiates macropinocytosis and uptake of apoptotic cells. J. Exp. Med. 194(6):781-796, 2001.

Huynh, M-LH, Fadok VA, Bratton DL, Henson PM. Phosphatidylserine-dependent ingestion of apoptotic cells promotes TGFb1 secretion and resolution of inflammation. J Clin Invest 109:41-50, 2002.

Vandivier RW, Fadok VA, Hoffmann PR, Bratton DL, Pendarvi C, Brain JD, Accurso FJ, Henson PM. Impaired clearance of apoptotic inflammatory cells in cystic fibrosis and bronchiectasis: role for elastase cleavage of the phosphatidylserine receptor. In press. 2002.

Robert Keith, M.D.

K Garg, Keith RL, Kerzner A, Kelly K, Lynch D, Byers T Miller YE. A Randomized Trial of Spiral CT Lung Cancer Screening. Radiology, in press.

Keith RL, Miller YE, Malkinson AM, Moore MD, Geraci MW. Manipulation of Prostacyclin Synthase Expression Prevents Murine Lung Cancer. Cancer Research, Feb. 1, 2002.

Keith RL, Miller YE, Cohen AJ. From COPD to Lung Cancer, in Chronic Obstructive Lung Disease, NF Voelkel and W MacNee (eds.), Hamilton, Ontario, BC Decker Inc., 2001 (p.403-415).

Keith RL, Miller YE, Gemmill RM, Drabkin HA, Kennedy TC, Dempsey EC, Prindiville S, Franklin WA. Angiogenic Squamous Dysplasia in Bronchi of High Risk Smokers. Clinical Cancer Research 6:1616-1625;2000.

Esther Langmack, M.D.

Langmack EL, Martin RJ, Pak J, Kraft M. Serum lidocaine concentrations in asthmatics undergoing research bronchoscopy. Chest 2000; 117:1055-1060.

Langmack EL, Wenzel SE. Lipid mediators: prostaglandins and leukotrienes. In: Altman LC, Becker JW, Williams PV, eds. Allergy in Primary Care. Philadelphia: W.B. Saunders, 2000: 20-24.

Langmack EL. Complimentary and alternative therapies for asthma. In Szefler SJ, Leung DYM, eds. Severe Asthma, Pathogenesis and Clinical Management, Second Edition, Lung Biology in Health and Disease Series. New York: Marcel Dekker, 2001:221-238.

Barry Make, M.D.

Boueri F, Bucher-Bartelson B, Glenn K, Make B. Quality of life measured with a generic instrument (Short Form-36) improves following pulmonary rehabilitation in COPD. Chest 2001; 119:77-84.

National Emphysema Treatment Trial Research Group. Patients at high risk of death after lung-volume-reduction surgery. New Engl J Med October 11. 2001: 345:15:1075-1083.

Ferguson GT, Fernandez E, Zamora MR, Pomerantz M, Buchholz J, Make BJ. Improved exercise tolerance following lung volume reduction surgery for emphysema. Am J Resp Crit Care Med 1998;157:1195-1203.

ACCP/AACVPR Pulmonary Rehabilitation Guidelines Panel. Special report: Pulmonary rehabilitation, Joint ACCP/AACVPR evidence-based guidelines. Chest 1997;112:1363-96.

Richard Martin, M.D.

Martin RJ, Chu HW, Honour JM, Harbeck RJ. Airway inflammation and bronchial hyperresponsiveness after Mycoplasma pneumoniae infection in a murine model. Am J Respir Cell Mol Biol 24:577-582, 2001.

Martin RJ, Kraft M, Chu HW, Berns EA, Cassell GH. A link between chronic asthma and chronic infection. J Allergy Clin Immunol 107:595-601, 2001.

Irvin CG, Pak J, Martin RJ. Airway-parenchymal uncoupling in nocturnal asthma. Am J Respir Crit Care Med 161:50-56, 2000.

Chu HW, Kraft M, Krause JE, Rex MD, Martin RJ. Substance P and its eceptor neurokinin 1 expression in asthmatic airways. J Allergy Clin mmunol 106:713-722, 2000.

Kraft M, Djukanovic R, Wilson S, Holgate S, Martin RJ. Alveolar tissue nflammation in asthma. Am J Respir Crit Care Med 154:1505-1510, 1996.

Robert J. Mason, M.D.

Pan, T., Robert J. Mason, R.J., Westcott, J.Y., and Shannon, J.M. Rat alveolar type II cells inhibit lung fibroblast proliferation in vitro. American Journal of Respiratory Critical Care Medicine Cell Mol. Biol., 25: 353-61, 2001.

Shannon, J. M., T. Pan, L. D. Nielson, K. McCormick-Shannon, K. E. Edeen, V. D. Koenigsknecht, and R. J. Mason. Lung fibroblasts support improved differentiation of rat alveolar type II cells in primary culture. Am. J Respir. Cell Mol Biol., 24: 235-244, 2001.

Yano, T., R. J. Mason, T. Pan, R. R. Deterding, L. D. Nielsen, and J. M. Shannon. KGF regulates pulmonary epithelial proliferation and surfactant protein gene expression in the adult rat lung. Am J Physiol Lung Cell Mol Physiol 279:L1146-L1158. 2000

Morikawa, O., T. A. Walker, L. D. Nielsen, T. Pan, J. L. Cook, and R. J. Mason. Effect of adenovector-mediated gene transfer of keratinocyte growth factor on the proliferation of alveolar type II cells in vitro and in vivo. Am J. Respir Cell Mol Biol 23:626-635, 2000.

Mason, R.J. , Lewis, M.C., Edeen, K.E., McCormick-Shannon, K., Nielsen, L.D., and Shannon, J.M. Maintenance of surfactant protein A and D secretion by rat alveolar type II cells in vitro. Am J Physiol Lung Cell Mol Physiol, 282(2)L249-258, 2002.

J.M. McCord, Ph.D.

J.M. McCord and I. Fridovich, Superoxide Dismutase: an Enzymic Function for Erythrocuprein (Hemocuprein), J. Biol. Chem. 244: 6049-6055 (1969).

J.M. McCord, Oxygen-Derived Free Radicals in Post-Ischemic Tissue Injury, New Eng. J. Med. 312:159-163 (1985).

S.K. Nelson, S.K. Bose, and J.M. McCord, The toxicity of high-dose superoxide dismutase suggests that superoxide can both initiate and terminate lipid peroxidation in the reperfused heart, Free Radical Biol. Med. 16:195-200 (1994).

J.M. McCord, Evolution of free radicals and oxidative stress. Am. J. Med. 108: 652-659 (2000).

S.K. Nelson, B. Gao, S. Bose, M. Rizeq and J.M. McCord, A novel mutant human Mn-superoxide dismutase improves myocardial preservation and protects from ischemia/reperfusion injury. J. Heart Lung Transplant. in press (2002).

Ivan McMurtry, Ph.D.

Ivy DD, McMurtry IF, Yanagisawa M, Gariepy CE, Le Cras TD, Gebb SA, Morris KG, Abman SH. Endothelin B receptor deficiency potentiates ET-1 and hypoxic pulmonary vasoconstriction. Am J Physiol Lung Cell Mol Physiol 280: L1040-L1048, 2001.

Nagaoka T, Muramatsu M, Sato K, McMurtry I, Oka M, Fukuchi Y. Mild hypoxia causes severe pulmonary hypertension in fawn-hooded but not in Tester Moriyama rats. Respir Physiol 127: 53-60, 2001.

Fagan KA, Morrissey B, Fouty BW, Sato K, Harral JW, Morris KG, Hoedt-Miller M, Vidmar S, McMurtry IF, Rodman DM. Upregulation of nitric oxide synthase in mice with severe hypoxia-induced pulmonary hypertension. Respir Res 2: 306-313, 2001.

Ivy DD, Yanagisawa M, Gariepy CE, Gebb SA, Colvin KL, McMurtry IF. Exaggerated hypoxic pulmonary hypertension in endothelin B receptor deficient rats. Am J Physiol Lung Cell Mol Physiol 282: L000-L000, 2002.

Morio Y, McMurtry IF. Ca2+ release from ryanodine-sensitive store contributes to mechanism of hypoxic vasoconstriction in rat lungs. J Appl Physiol 92: 527-534, 2002.

York Miller, M.D.

Franklin, WA, Gazdar, AF, Haney, J, Wistuba, II, LaRosa, FG, Kennedy, T, Ritchey, DM, Miller, YE. Widely dispersed p53 mutation in respiratory epithelium: Novel mechanism for field carcinogenesis. Journal of Clinical Investigation 100:2133-2137, 1997.

Cook, RM, Moore, M, Johnson, B, Franklin WF, and Miller, YE. Mutational inactivation of aminoacylase-1 in a small cell lung cancer cell line. Genes, Chromosomes and Cancer 21:320-325, 1998.

Keith, RL, Miller, YE, Gemmill, R, Dempsey, EC, Kennedy, T, Franklin, WA. Angiogenic squamous dysplasia in bronchi of smokers at high risk for lung cancer. Clinical Cancer Research 6:1616-1625, 2000.

Hirsch, FR, Prindiville, SA, Miller, YE, Franklin, WA, Dempsey, EC, Murphy, J, Bunn, PA and Kennedy, TC. A randomized study of autofluorescence bronchoscopy versus white light bronchoscopy for the detection of preneoplastic lesions in high risk smokers. Journal of the National Cancer Institute 93:1385-1391, 2001.

Keith, RL, Miller, YE, Hoshikawa, Y, Moore, MD, Gesell, TL, Gao, BF, Malkinson, AM, Golpon, HA, Nemenoff, RA and Geraci, MW. Manipulation of pulmonary prostacyclin synthase expression prevents murine lung cancer. Cancer Research 62:734-740, 2002.

Garg, K, Keith, RL, Byers, T, Kelly, K, Kerzner, AL, Lynch, DA, Miller, YE. A feasibility study for a randomized, controlled trial of low-dose spiral CT for lung cancer screening. In press, Radiology, 2002.

Miller, YE. Lung cancer and other pulmonary neoplasms in Cecil Textbook of Medicine, 22nd Edition, ed. Goldman, L, Ausiello, D, in press, 2002

Lee Newman, M.D.

Newman LS. Current concepts: Occupational illness. N Engl J Med 1995; 333:1128-1134.

Newman LS, Maier L, Rose CS. Medical Progress: Sarcoidosis. N Engl J Med 1997; 336:1224-1234.

Tinkle SS, Kittle LA, Newman LS. Partial IL-10 inhibition of the cell-mediated immune response in chronic beryllium disease. J Immunol 1999;163:2747-2753.

Mayer AS, Stoller JK, Bucher Bartelson B, Ruttenber AJ, Sandhaus RA, Newman LS. Occupational exposure risks in individuals with PI*Z a1-antitrypsin deficiency. Am J Respir Crit Care Med 2000; 162: 553-558.

Newman LS, Mroz MM, Maier LA, Daniloff EM, Balkissoon R. Efficacy of serial medical surveillance for chronic beryllium disease in a beryllium machining plant. J Occup Environ Med 2001; 43:231-237.

Jerry Nick, M.D.

Avdi, N.J., J. A Nick, B. B. Whitlock, M. A. Billstrom, P. M. Henson, G. L. Johnson, G. S. Worthen. 2001. TNFa activation of the c-Jun NH2-terminal Kinase (JNK) pathway in human neutrophils: Integrin involvement in a pathway leading from cytoplasmic tyrosine kinase to apoptosis. J Biol Chem, 276(3),2189-99.

Nick, J. A. , S. K. Young, K. K. Brown, N. J. Avdi, P. G. Arndt, B. T. Suratt, M. Janes, P. M. Henson and G. S. Worthen. 2000. Role of p38 MAP Kinase in a Murine Model of Pulmonary Inflammation. Journal of Immunology: 164:2151-2159.

Nick, J. A. , N. J. Avdi, S. K. Young, L. A. Lehman, P. P. McDonald, S. C. Frasch, M. A. Billstrom, P. M. Henson, G. L. Johnson and G. S. Worthen. 1999. Selective activation and functional significance of p38a mitogen-activated protein kinase in lipopolysaccharide-stimulated neutrophils. Journal of Clinical Investigation. 103:851-858.

Frasch, S. C., J. A. Nick, F. V. A, D. L. Bratton, G. S. Worthen and P. M. Henson. 1998. p38 Mitogen-activated Protein Kinase-dependent and -independent Intracellular Signal Transduction Pathways Leading to Apoptosis in Human Neutrophils. Journal Biological Chemistry. 273:8389-8397.

Nick, J. A. , N. J. Avdi, S. K. Young, C. Knall, G. L. Johnson and G. S. Worthen. 1997. Common and distinct intracellular signalling pathways in human neutrophil utilized by platelet activating factor and FMLP. Journal of Clinical Investigation. 99:975-986.

Nick, J. A. , N. J. Avdi, P. Gerwins, G. L. Johnson and G. S. Worthen. 1996. Activation of a p38 mitogen-activated protein kinase in human neutrophils by lipopolysaccharide. Journal of Immunology. 156:4867-4875.

Mark Nicolls, M.D.

Nicolls MR, Coulombe M, Gill RG. The basis of immunogenicity of endocrine allografts. Crit Rev Immunol 2001; 21:87-101.

Tran GT, Carter N, He XY, Spicer TS, Plain KM, Nicolls M, Hall BM. Hodgkinson SJ. Reversal of experimental allergic encephalomyelitis with non-mitogenic, non-depleting anti-CD3 mAb therapy with a preferential effect on T(h)1 cells that is augmented by IL-4. Int Immunol 2001; 13:1109-1120.

Nicolls MR, Coulombe M, Bolwerk A, Gill RG. Anti-LFA-1-induced allograft prolongation does not require IL-4 or IFNg. J Immunol. 2000; 164:3627-3634.

Manisha Patel, Ph.D.

Patel M, Day BJ, Crapo JD, Fridovich I and McNamara JO. Requirement for superoxide in excitotoxic cell death. Neuron 16:345-355, 1996.

Liang LP, Y.S. Ho and Patel M. Mitochondrial superoxide production in kainate-induced hippocampal damage. Neuroscience 101(3):563-570, 2000.

Patel M and Day BJ. Metalloporphyrin class of therapeutic catalytic antioxidants. Trends Pharmacol Sci 20:359-364, 1999.

Li QY, Pedersen C, Day BJ and Patel M. Dependence of excitotoxic neurodegeneration on mitochondrial aconitase inactivation J. Neurochem. 78(4):746-755, 2001.

Patel M, Liang LP and Roberts LJ. Enhanced hippocampal F2-isoprostane formation following kainate-induced seizures. J. Neurochem. 79(5), 1065-1070, 2001.

Thomas Petty, M.D.

Petty TL, Winemann GG: Building a national strategy for the prevention and management of and research in chronic obstructive pulmonary disease. JAMA 1997; 277: 246-253.

Petty TL,(ed). Strategies in preserving lung health and preventing COPD and associated disease. The National Lung Health Education Program (NLHEP). Chest 1998;113:123s-163s.

Petty TL, In the cards was ARDS (How we discovered the acute respiratory distress syndrome. Am J. Respir Crit Care Med 2001; 163: 602-603.

Petty TL, Simple Office Spirometry. Clinics in Chest Med 2001; 22: 845-859.

Petty TL, The early diagnosis of lung cancer. Disease-a-Month, 2001; 47:201-264.

David Riches, Ph.D.

S-t Uh, A. Van Linden and D.W.H. Riches. 2000. Phosphorylation of 130 and 95 kDa substrates associated with tumor necrosis factor-a receptor CD120a (p55). J. Biol. Chem. 275:793-800.

A.A. Van Linden, V. Cottin C. Leu and D.W.H. Riches. 2000. Phosphorylation of the membrane proximal region of TNF receptor CD120a (p55) at ERK consensus sites. J. Biol. Chem. 275:6996-7003

V. Cottin A.A. Van Linden and D.W.H. Riches. 2001. Phosphorylation of TNF receptor CD120a (p55) recruits Bcl-2 and protects against apoptosis. J. Biol. Chem. 276:17252-17260

E.D. Chan, K.R. Morris, J.T. Belisle, P. Hill, L.K. Remigio, P.J. Brennan and D.W.H. Riches. 2001 Induction of iNOS-NO by lipoarabinomannan of Mycobacterium tuberculosis is mediated by MEK1-ERK, MKK7-JNK and NF-kB signaling pathways. Infect. Immunity. 69:2001-2010.

Richard Sawyer, M.D.

Sawyer RT, Fadok VA, Kittle LA, Maier LA, Newman LS. Beryllium-stimulated apoptosis in macrophage cell lines. Toxicology 2000; 149:129-142.

Maier LA, Sawyer RT, Tinkle SS, Kittle LA, Barker EA, Balkissoon R, Rose C, Newman LS. IL-4 fails to regulate in vitro beryllium-induced cytokines in berylliosis. Eur. Respir. J. 2001; 17:403-415.

Maier LA, Sawyer RT, Bauer RA, Kittle LA, Lympany P, McGrath D, duBois R, Daniloff E, Rose CS, Newman LS. Beryllium-stimulated TNF-a is associated with the 308 TNF-a promoter polymorphism and with clinical severity in chronic beryllium disease. Am. J. Respir. Crit. Care Med. 2001; 164:1192-1199.

Sawyer RT, Maier LA, Kittle LA, Newman LS. Chronic beryllium disease: A model interaction between innate and acquired immunity. Internatl. Immunopharmacol. 2002; 2:249-261.

Kittle LA, Sawyer RT, Fadok VA, Maire LA, Newman LS. Beryllium induced human lung macrophage apoptosis. 2002; Sarc. Vasc. Diff. Lung Dis. (in press).

Marcella Billstrom Schroeder, M.D.

MA Billstrom, WJ Britt. Post-oligomerization folding of human cytomegalovirus glycoprotein B: Identification of folding intermediates and importance of disulfide bonding. Journal of Virology, 1995, 69, 7015-7022.

MA Billstrom, N Avdi, GL Johnson, GS Worthen. Intracellular signaling by the chemokine receptor US28 during human cytomegalovirus infection. Journal of Virology, 1998, 72, 5535-5544.

MA Billstrom, L Lehman, GS Worthen. Depletion of RANTES during human cytomegalovirus infection of endothelial cells. 1999, American Journal of Respiratory Cell and Molecular Biology, 21, 163-167.

MA Billstrom Schroeder, GS Worthen. Viral regulation of RANTES expression during human cytomegalovirus infection of endothelial cells, 2001 Journal of Virology, 75: 3383-3390.

Philip Silkoff, M.D.

Kissoon N, Duckworth LJ, Blake KV, Murphy SP, Taylor CL, Silkoff PE. FE(NO): relationship to exhalation rates and online versus bag collection in healthy adolescents. Am J Respir Crit Care Med 2000; 162(2 Pt 1):539-45.

Silkoff PE, Sylvester JT, Zamel N, Permutt S. Airway nitric oxide diffusion in asthma: Role in pulmonary function and bronchial responsiveness. Am J Respir Crit Care Med 2000; 161(4 Pt 1):1218-1228.

Document prepared by Silkoff PE. Recommendations for standardized procedures for the on-line and off-line measurement of exhaled lower respiratory nitric oxide and nasal nitric oxide in adults and children-1999. This official statement of American Thoracic Society was adopted by the ATS Board of Directors, July 1999. Am J Respir Crit Care Med 1999; 160(6):2104-2117.

Chatkin JM, Ansarin K, Silkoff PE, McClean P, Gutierrez C, Zamel N, Chapman KR. Exhaled nitric oxide as a noninvasive assessment of chronic cough. Am J Respir Crit Care Med 1999; 159(6):1810-1813.

Silkoff PE, Wakita S, Chatkin J, Ansarin K, Gutierrez C, Caramori M, McClean P, Slutsky AS, Zamel N, Chapman KR. Exhaled nitric oxide after beta2-agonist inhalation and spirometry in asthma. Am J Respir Crit Care Med 1999; 159(3):940-944.

Silkoff PE, Caramori M, Tremblay L, McClean P, Chaparro C, Kesten S, Hutcheon M, Slutsky AS, Zamel N, Keshavjee S. Exhaled nitric oxide in human lung transplantation. A noninvasive marker of acute rejection. Am J Respir Crit Care Med 1998; 157(6 Pt 1):1822-1828.

Silkoff PE, McClean PA, Slutsky AS, Furlott H, Hoffstein E, Wakita S, Chapman KR, Szalai JP, Zamel N. Marked flow-dependence of exhaled nitric oxide using a new technique to exclude nasal nitric oxide. Am J Respir Crit Care Med 1997; 155(1):260-267.

Benjamin Suratt, M.D.

BT Suratt, SK Young, JG Leiber, PM Henson, GS Worthen, Regulation of neutrophil clearance from the circulation: Anatomic site and effect of activation. Am J Physiol 281:L913-21, 2001.

JA Nick, SK Young, KK Brown, NJ Avdi, BT Suratt, MS Janes, PM Henson, GS Worthen, Role of p38 MAP kinase in a murine model of pulmonary inflammation. J Immunol 164: 2151-9, 2000.

BT Suratt, SR Young, GS Worthen, Neutrophils sequester in marrow via sialoadhesin binding. Am J Resp Critical Care Med 161: S256, 2000.

Norbert Voelkel, M.D.

RM Tuder, Chacon M, Alger L, Wang J, Cool CD, Bishop AE, Geraci M, Semenza GL, Yacoub M, Polak JM, and Voelkel NF: Expression of angiogenesis-related molecules in plexiform lesions in severe pulmonary hypertension: evidence for a process of disordered angiogenesis. J Path 2001; 195:367-374.

MW Geraci, Moore M, Gao B, Loyd JE, Tuder RM, and Voelkel NF: Gene expression patterns in the lungs of patients with primary pulmonary hypertension -- a gene microarray analysis. Circ Res 2001; 88:555-562.

NF Voelkel, Clark WR, Higenbottam T: Obesity, dexfenfluramine, and pulmonary hypertension: A lesson not learned? Am J Respir Crit Care Med 1997; 155:786-788.

M Taraseviciene, Kasahara Y, Alger L, Hirth P, McMahon G, Waltenberger J, Voelkel NF, Tuder RM: Inhibition of the VEGF receptor-2 combined with chronic hypoxia causes severe pulmonary hypertension with pulmonary endothelial cell proliferation. FASEB J 2001; 15-427-438.

Y Kasahara, Tuder TM, Cool CD, Lynch DA, Flores SC, and Voelkel NF: Endothelial cell death and decreased expression of vascular endothelial growth factor and its receptor KDR/Flk-1 in smoking-induced emphysea. Am J Resp Crit Care Med 2001; 163:737-744.

Ming-Hai Wang, Ph.D.

Wang, M.-H., Ronsin, C., Gesnel, M.-C., Coupey, L., Skeel, A., Leonard, E.J. and Breathnach, R. Identification of the RON gene product as the receptor for the human macrophage stimulating protein. Science. 1994, 266:117-119.

Wang, M.-H., Montero-Julian, F.A., and Leonard, E.J. Requirement of PI-3 kinase for epithelial cell migration activated by human macrophage stimulating protein. Oncogene. 1996, 13:2167-2175.

Wang, M.-H., Montero-Julian, F., Breathnach, R., Godowski, P.J., Takehara, T., Yoshikawa, W., Hagiya, M., and Leonard, E.J. Macrophage stimulating protein (MSP) binds to its receptor via the MSP b chain. J. Biol. Chem. 1997, 272: 6999-17004.

Wang, M.-H., Fang, H.-L. and Chen Y.-Q. Identification of a novel splicing variant of the RON receptor tyrosine kinase in human colorectal carcinoma cell lines. Carcinogenesis 21, 1507-1512, 2000.

Chen, Y.-Q., Y.-Q., Zhou, Y.-Q., Angeloni-Andreazzoli, D., Kurtz, A.L., Qiang, X.-Z., and Wang, M.-H., Oveerexpression and activation of the receptor tyrosine kinase in a panel of human colorectal carcinoma cells lines. Exp. Cell Res. 261:229-238, 2000.

Carolyn H. Welsh

CH Welsh, KL Hassell, DB Badesch, DC Kressin, RA Marlar. Coagulation and fibrinolytic abnormalities in patients with severe pulmonary hypertension. Chest 110:710-717, 1996.

Carolyn H. Welsh. Coagulation and Fibrinolytic factors in Pulmonary Hypertension. Chapter 20 in Interactions of Blood and the Pulmonary Circulation edited by EK Weir, HL Reeve, JT Reeves. Futura Publishing Co. Armonk NY. pages 339-360.

Roche Vivyenne, CH Welsh. Long-term Functional Outcome after ICU. J American Ger Soc, January 1999: 11-17.

CH Welsh, K Thompson, S Long-Krug. Evaluation of patient-perceived health status using medical outcomes survey short-form 36 in an intensive care unit population. Crit Care Med, 1999; 27: 1466-1471.

Sally Wenzel, M.D.

Wenzel S, Schwartz LB, Langmack EL, Halliday JL, Trudeau JB, Gibbs RL, Chu W. Evidence that severe asthma can be divided pathologically into two nflammatory subtypes with distinct physiologic and clinical characteristics. Am J Respir Crit Care Med 160:1001-1008, 1999.

Wenzel SE, Larsen GL, Johnston K, Voelkel NF, Westcott JY. Elevated levels of leukotriene C4 in bronchoalveolar lavage fluid from atopic asthmatics after endobronchial allergen challenge. Am Rev Respir Dis 142:112-119, 1990.

Wenzel SE, Trudeau JB, Kaminsky DA, Cohn J, Martin RJ, Westcott JY. Effect of 5 lipoxygenase inhibition on bronchoconstriction and airway inflammation in nocturnal asthma. Am J Resp Crit Care Med 152:897-905, 1995.

Wenzel SE, Szefler SJ, Leung DYM, Sloan SI, Rex MD, Martin RJ. Bronchoscopic evaluation of severe asthma: persistent inflammation associated with high dose glucocorticoids. Am J Respir Crit Care Med 156:737-743, 1997.

G. Scott Worthen, M.D.

Nick JA, Young SK, Brown K, Avdi NJ, Arndt PG, Suratt BT, Janes MS, Henson PM, Worthen GS. Role of p38 MAP kinase in a murine model of pulmonary inflammation. J Immunol. 164:2151-2159, 2000.

Avdi N, Nick JA, McDonald PP, Billstrom MA, Henson PM, Johnson GL, Worthen GS. TNF-a activation of C- Jun N-Terminal Kinase Pathway in Human Neutrophils. Integrin involvement in a pathway leading from cytoplasmic tyrosine kinases to apoptosis. J Biol. Chem. 276(3):2189-2199, 2001.

Billstrom-Schroeder M, Worthen GS. Viral Regulation of RANTES Expression during Human CMV infection of Endothelial Cells. J Virology. 75(7):3383-3390, 2001.

Suratt BT, Young SK, Lieber J, Nick JA, Henson PM, Worthen GS. Neutrophil maturation and activation determine anatomic site of clearance from circulation. Am J Physiology. 281:L913-921, 2001.