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Colorado Pulmonary-Alcohol Research Consortium (CoPARC)

 

Documents & Resources


Case report forms have been designed to collect clinical data consistently across sites. All are available directly on the REDCap site if user access has been granted. Individual .pdf documents of unique forms are provided below.

Patients with Burn Injury in a Designated Burn ICU

Subjects with Alcohol Use Disorders (AUDs) and Non-AUD Control Subjects

Patients with Respiratory Failure on Mechanical Ventilation

Active CoPARC Lab Processing and Experimental Methods

Current methods for the processing of CoPARC samples along with methods for the experiments performed in the CoPARC laboratory.

Previous and Specialized CoPARC Lab Methods

Former methods for CoPARC sample processing that are not currently in use but may be relevant to previously collected samples, as well as methods for specialized assays.

Distribution of data and samples from CoPARC will be directed by the Data and Sample Sharing Committee (DSSC). The DSSC will prioritize distribution of samples and information based on the following criteria:

  • Availability of needed samples and its ease of acquisition
  • Quantity and type of samples needed
  • Timeframe that investigator requests to receive samples
  • Quantity and type of samples previously given to the site
  • Study design of proposed experiments with samples
  • Funding available to requesting investigator(s) to conduct the project

Necessary regulatory (IRB) approval will be required for proposed projects prior to sites receiving samples or data. The DSSC may request modifications or clarifications of the proposed protocol prior to its approval based on their review. The committee will make every effort to honor all requests. All data generated through the resources of this consortium will be uploaded to the consortium's main data set in a timely fashion, but may not be accessed without approval from the DSSC.

In order to help determine priority order of sample distribution, please email the following to coparc@ucdenver.edu:

  1. Up-to-date biosketch of principal investigator(s)
  2. Project Description Form
  3. Sample Distribution Request
  4. Data Distribution Request

CoPARC Collected Sample Types

Blood Bronchoalveolar Lavage (BAL) Bronchial Brushings Other
Serum Cell Free Upper BAL (Bronchial) *Microbiome Cytobrush Oral Wash
EDTA Plasma (Purple Top) Cell Free Lower BAL (Alveolar) Cytobrush Cells for RNA *Microbiome Oral Wash
Buffy Coat from EDTA Plasma Uncultured BAL Cell Pellets for RNA Cytobrush Cell Cytospins, Methanol Fixed Urine
Heparin Plasma (Green Top) Uncultured BAL Cell Pellets for Protein Cytobrush Cell Cytospins, Paraformaldehyde Fixed
Red Blood Cells from Heparin Plasma Cultured BAL Cell Pellets for RNA
Whole Blood from Heparin Plasma Tube Cultured BAL Cell Media
Uncultured Peripheral Blood Mononuclear Cell (PBMC) Pellets *Microbiome BAL
Cultured PBMC Pellets Cytospins, Methanol Fixed
Cultured PBMC Cell Media Cytospins, Paraformaldehyde Fixed *Microbiome = Collected in DNA free conditions.

Samples Available from Other Consortium Members

Consortium sites that have samples available for sharing. Those sites will update CoPARC with the number and type of samples quarterly so that CoPARC team members can facilitate the shipment of samples from those sites to the requesting investigator(s). The following consortium members are participating:

Ashish Mehta Emory University Longitudinal BAL and Blood from Subjects with AUDs
Majid Afshar Loyola University BAL and Blood from Patients with Burn Injury