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Xiyuan Bai Ph.D.


 

EDUCATION/TRAINING
Westfalische Wilhelms-University Muenster, Germany, PhD in Molecular Microbiology/Biochemistry 1997
Postdoctoral fellow, the Department of Microbiology, Biochemistry and Genetic, University Nuerberg-Erlangen, Germany 1999-2000
Postdoctoral fellow in McLaughlin Research Institute for Biomedical Sciences, Great Falls, MT. 2000-2002
Research Associate, the department of Medicine, National Jewish Medical and Research Center, University of Colorado Health Sciences Center, Denver, CO. 2003-2005

Interests Research Area:
Host cell immune response to M. tuberculosis Infection including M. avium, M. abscessus. Cytokine Signaling, Gene regulation and expression, Molecular Mycobacteriology, protein kinase CK2 pathway. Transgenic Mouse to study human diseases such as Tuberculosis .

SELECTED PEER-REVIEWED PUBLICATIONS

Bai X, Kim SH, Azam T, McGibney MT, Huang H, Dinarello CA, Chan ED. IL-32 Is a Host Protective Cytokine against Mycobacterium tuberculosis in Differentiated THP-1 Human Macrophages. J Immunol. 2010 Feb 26.

Chan ED, Bai X, Kartalija M, Orme IM, Ordway DJ. Host Immune Response to Rapidly-Growing Mycobacteria, an Emerging Cause of Chronic Lung Disease.
Am J Respir Cell Mol Biol. 2010 Jan 15.

Hong J, Bae S, Kang Y, Yoon D, Bai X, Chan ED, Azam T, Dinarello CA, Lee S, Her E, Rho G, Kim S. Suppressing IL-32 in monocytes impairs the induction of the proinflammatory cytokines TNFalpha and IL-1beta. Cytokine. 2010 Feb;49(2):171-6.

Morris KR, Lutz RD, Bai X, McGibney MT, Cook D, Ordway D, Chan ED. Suppression of IFNgamma+mycobacterial lipoarabinomannan-induced NO by IL-4 is due to decreased IRF-1 expression.Tuberculosis (Edinb). 2009 Jul;89(4):294-303.

Bai X, Silvius D, Chan ED, Escalier D, Xu SX.Identification and characterization of a novel testis-specific gene CKT2, which encodes a substrate for protein kinase CK2. Nucleic Acids Res. 2009 May;37(8):2699-711.

Chmura K, Bai X, Nakamura M, Kandasamy P, McGibney M, Kuronuma K, Mitsuzawa H, Voelker DR, Chan ED. Induction of IL-8 by Mycoplasma pneumoniae membrane in BEAS-2B cells. Am J Physiol Lung Cell Mol Physiol. 2008 Jul;295(1):L220-30.

Ordway D, Henao-Tamayo M, Smith E, Shanley C, Harton M, Troudt J, Bai X, Basaraba RJ, Orme IM, Chan ED. Animal model of Mycobacterium abscessus lung infection. J Leukoc Biol. 2008 Jun;83(6):1502-11.

Chan ED, Kaminska AM, Gill W, Chmura K, Feldman NE, Bai X, Floyd CM, Fulton KE, Huitt GA, Strand MJ, Iseman MD, Shapiro L. Alpha-1-antitrypsin (AAT) anomalies are associated with lung disease due to rapidly growing mycobacteria and AAT inhibits Mycobacterium abscessus infection of macrophages. Scand J Infect Dis. 2007; 39(8): 690-6.
 
Bai X, Wilson SE, Chmura K, Feldman NE, Chan ED. Morphometric analysis of Th(1) and Th(2) cytokine expression in human pulmonary tuberculosis. Tuberculosis (Edinb). 2004;84(6):375-85.

Bai X, Chan ED, Xu X. The protein of a new gene, Tctex4, interacts with protein kinase CK2beta subunit and is highly expressed in mouse testis. Biochem Biophys Res Commun. 2003 Jul 18;307(1):86-91.

Escalier D. Bai X, Sylvius D, Xu PX and Xu X. Spermatid nuclear and sperm periaxonemal anomalies in mouse Ub2b null mutant. Mol Reprod Dev. 2003, 65(3):298-308