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David Riches, Ph.D.

Professor of Medicine


 



 

  David Riches, Ph.D.

  Professor of Medicine
  University of Colorado Denver

  Pulmonary Sciences & Critical Care Medicine

  Phone: 303-724-0000

  richesd@njc.org

 

 

Education & Training

University of Birmingham, England
1976 B. Sc. (Hons) Biochemistry
1979 Ph.D. Immunology


 PROFESSIONAL EXPERIENCE

1985-1992
Assistant Faculty Member, Department of Pediatrics, National Jewish Center for Immunology and Respiratory Medicine, Denver, CO

1985-1992
Assistant Professor, Department of Biochemistry, Biophysics and Genetics, University of Colorado Denver, Denver, CO

1989-1992
Assistant Professor. Division of Pulmonary Sciences, Department of Medicine, University of Colorado Denver, Denver, CO

1992-present
Associate Faculty Member, Division of Basic Science, Department of Pediatrics, National Jewish Center for Immunology and Respiratory Medicine, Denver, CO

1993-present
Associate Professor, Department of Biochemistry, Biophysics and Genetics, Division of Pulmonary Sciences and Critical Care Medicine, Dept of Medicine and Dept of Immunology University of Colorado Denver, Denver, CO

1998
Senior Faculty Member, Program in Cell Biology, National Jewish Medical and Research Center, Denver, CO

1998
Professor, Department of Biochemistry and Molecular Genetics, Division of Pulmonary Sciences and Critical Care Medicine, Dept of Medicine and Dept of Immunology, University of Colorado Denver, Denver, CO

SELECTED PEER-REVIEWED PUBLICATIONS (Selected from 77 peer-reviewed publications)

1.D.W.H. Riches and G.A. Underwood. 1991. Expression and functional role of IFN b during the triggering phase of macrophage activation induced by polynucleotides. J. Biol. Chem. 266:24785-24792.

2.G.A. Underwood and D.W.H. Riches. 1992. Transmembrane-mediated changes in [Ca2+]i are involved in the signalling pathway leading to macrophage cytocidal differentiation. Implications of localized changes in [Ca2+]i and of IFN-priming on Ca2+ utilization. Mol. Biol. Cell. 3:335-347.

3.P.W. Noble, F.R. Lake, P.M. Henson and D.W.H. Riches. 1993. Hyaluronate activation of CD44 induced Insulin growth factor-1 expression by a tumor-necrosis factor-a-dependent mechanism in murine macrophages. J. Clin. Invest. 91:2368-2377.

4.P.W. Noble, P.M. Henson, C. Lucas, M. Mora-Worms, P.C. Carre and D.W.H. Riches. 1993. TGFb primes macrophages to express inflammatory gene products in response to particulate stimuli by an autocrine/paracrine mechanism. J. Immunol. 151:979-989.

5.F.R. Lake, J. Dempsey, J.D. Spahn and D.W.H. Riches. 1994. Involvement of protein kinase C in the triggering phase of macrophage cytocidal activity. Am. J. Physiol. 266:C134-C142.

6.P.C. Carre, T.E. King Jr., R. Mortenson and D.W.H. Riches. 1994. Cryptogenic organizing pneumonia: Increased expression of interleukin 8 and fibronectin genes by alveolar macrophages. Am. J. Respir. Cell. Molec. Biol. 10:100-105


7.F.R. Lake, P.W. Noble, P.M. Henson and D.W.H. Riches. 1994. Functional switching of macrophage responses to TNFa by interferons. Implications for the pleiotropic activities of TNFa. J. Clin. Invest. 93:1661-1669.


8.T.Z. Khan, J.S. Wagener, T. Bost, J. Martinez, F.J. Accurso, and D.W.H. Riches. 1995. Early pulmonary inflammation in infants with cystic fibrosis identifiedthrough newborn screening. Am. J Respir. Crit Care Med. 151:1075-1082.


9.B.W. Winston, C. Lange-Carter, A. Gardner, G.L. Johnson and D.W.H. Riches. 1995. TNFa rapidly activates the MEK/MAP kinase cascade in an MEKK-dependent, c-Raf-1-independent fashion in mouse macrophages. Proc. Natl. Acad. Sci. U.S.A. 92:1614-1618.


10.B.W. Winston and D.W.H. Riches. 1995. Activation of p42mapk/erk2 following engagement of TNF receptor CD120a (p55) in mouse macrophages. J. Immunol. 155:1525-1533.


11.B.W. Winston, L.K. Remigio and D.W.H. Riches. 1995 Preferential Involvement of MEK1 in the TNFa-Induced Activation of p42mapk/erk2 in Mouse Macrophages. J. Biol Chem. 270:27391-27394.


12.B.W. Winston, E.D. Chan, G.L. Johnson and D.W.H. Riches 1997. Activation of p38mapk, MKK3 and MKK4 by tumor necrosis factor-a in mouse bone marrow-derived macrophages. J. Immunol. 159:4491-4497


13.E.D. Chan, B.W. Winston, M.Jarpe, M. Wynes and D.W.H. Riches. 1997. Preferential activation of the p46 isoform of JNK/SAPK in mouse macrophages by TNFa. Proc. Natl. Acad. Sci. U.S.A. 94:13169-13174.

 
14.D.W.H Riches, E.D. Chan, E.A. Zahradka, B.W. Winston, L.K. Remigio and F.R. Lake. 1998. Co-operative signalling by tumor necrosis factor receptors CD120a (p55) and CD120b (p75) in the expression of nitric oxide and inducible nitric oxide syntheses by mouse macrophages. J. Biol. Chem. 273:22800-22806.


15.S-t. Uh, Y. Inoue, T.E. King, Jr., E.D. Chan, LPS. Newman and D.W.H. Riches. 1998. Morphometry analysis of insulin-like growth factor-I in lung tissues of patients with idiopathic pulmonary fibrosis. Am. J. Respir. Crit Care Med. 158:1626-1635.


16.E.D Chan and D.W.H. Riches. 1998. Potential role of the JNK/SAPK signal transduction pathway in the induction of iNOS by TNFa. Brioche. Biophys. Res. Commun. 253:790-796


17.E.D. Chan, B.W. Winston, S-T Uh, D.M. Rose, M W. Wynes and D.W.H. Riches. 1999. Evaluation of the role of mitogen activated protein kinases in the expression of inducible nitric oxide synthase by IFNg and TNFa in mouse macrophages. J. Immunol. 162:415-422.


18.C.L. Sable and D.W.H. Riches. 1999. Cloning and functional activity of a novel truncated form of annexin IV in mouse macrophages. Biochem. Biophys. Res. Commun. 258:162-167.


19.V. Cottin, A. Van Linden and D.W.H. Riches. 1999. Phosphorylation of TNF receptor CD120a (p55) by p42mapk/erk2 induces changes in its subcellular localization. J. Biol. Chem. 274:32975-32987.


20.S-t Uh, A. Van Linden and D.W.H. Riches. 2000. Phosphorylation of 130 and 95 kDa substrates associated with tumor necrosis factor-a receptor CD120a (p55). J. Biol. Chem. 275:793-800.


21.A.A. Van Linden, V. Cottin, C. Leu and D.W.H. Riches. 2000. Phosphorylation of the membrane proximal region of TNF receptor CD120a (p55) at ERK consensus sites. J. Biol. Chem. 275:6996-7003.


22.E.D. Chan and D.W.H. Riches. 2001. IFNg and LPS induction of iNOS is modulated by ERK, JNK/SAPK and p38mapk in a mouse macrophage cell line. Am. J. Physiol. Cell Physiol. 280:C441-C450.


23.V. Cottin A.A. Van Linden and D.W.H. Riches. 2001. Phosphorylation of TNF receptor CD120a (p55) recruits Bcl-2 and protects against apoptosis. J. Biol. Chem. 276:17252-17260.


24.E.D. Chan, K.R. Morris, J.T. Belisle, P. Hill, L.K. Remigio, P.J. Brennan and D.W.H. Riches. 2001 Induction of iNOS-NO by lipoarabinomannan of Mycobacterium tuberculosis is mediated by MEK1-ERK, MKK7-JNK and NF-kB signaling pathways. Infect. Immunity. 69:2001-2010.


25.V. Cottin A.A. Van Linden and D.W.H. Riches. 2001. Phosphorylation of TNF receptor CD120a (p55) recruits Bcl-2 and protects against apoptosis. J. Biol. Chem. 276:17252-17260.