James D. Crapo, M.D.
Professor of Medicine
University of Colorado Denver
Pulmonary Sciences & Critical Care Medicine
Education & Training
Brigham Young University, Provo, UT
1967 B.S. Chemistry
University of Rochester, Rochester, NY
PROFESSIONAL EXPERIENCE & HONORS
1971 - 1972 Intern, Harbor General Hospital, Torrance, CA
1972 - 1975 Staff Associate, Environmental Toxicology Branch, NIEHS, Research Triangle Park, NC
1974 - 1975 Fellow, Pulmonary Medicine, Duke Univ Med Ctr, Durham, NC
1975 - 1976 Resident in Medicine, Duke Univ Med Ctr, Durham, NC
1976 - 1979 Assistant Professor of Medicine, Duke Univ Med Ctr, Durham, NC
1979 - 1985 Associate Professor of Medicine, Duke Univ Med Ctr, Durham, NC
1979 - 1996 Chief, Pulmonary/Critical Care Division, Dept of Medicine, Duke Univ Med Ctr, Durham, NC
1982 - 1987 Assistant Professor of Pathology, Duke Univ Med Ctr, Durham, NC
1984 Guest Professor, Anatomisches Institute, Universität Bern, Bern, Switzerland
1985 - 1997 Director, Center for Extrapolation Modeling, Duke Univ Med Ctr, Durham, NC
1986 - 1997 Professor of Medicine, Duke Univ Med Ctr, Durham, NC
1987 - 1991 Associate Professor of Pathology, Duke Univ Med Ctr, Durham, NC
1992 - 1997 Professor of Pathology, Duke Univ Med Ctr, Durham, NC
1996 - Date Chairman, Department of Medicine, National Jewish Center, Denver, CO
1996 - Date Executive Vice President - Academic Affairs, National Jewish Center, Denver, CO
1996 - Date Vice Chairman - Academic Affairs, Dept of Medicine, Univ of Colorado Health Sciences Ctr, Denver
1996 - Date Director: Graduate Program in Clinical Science, Univ of Colorado Health Sciences Center, Denver, CO
1997 - Date Professor of Medicine, University of Colorado Denver, Denver, CO
1.Crapo JD and DF Tierney. Superoxide dismutase and pulmonary O2 toxicity. Am J Physiol 226:1401-1407, 1974.
2.Crapo JD, BE Barry, HA Foscue and J Shelburne. Structural and biochemical changes in rat lungs occurring during exposure to lethal and adaptive doses of oxygen. Am Rev Respir Dis 122:123-143, 1980.
3.Slot JW, HJ Geuze, BA Freeman and JD Crapo. Intracellular localization of the copper?zinc and manganese superoxide dismutases in rat liver parenchymal cells. Lab Invest 55:363?371, 1986.
4.Ho Y-S and JD Crapo. Isolation and characterization of complementary DNAs encoding human manganese-containing superoxide dismutase. FEBS Lett 229:256-260, 1988.
5.Oury TD, Y-S Ho, CA Piantadosi and JD Crapo. Extracellular superoxide dismutase, nitric oxide and central nervous system O2 toxicity. Proc Nat'l Acad Sci USA 89:9715-9719, 1992.
6.Clyde BL, LY Chang, RL Auten, Y-S Ho and JD Crapo. Distribution of manganese superoxide dismutase mRNA in normal and hyperoxic rat lung. Am J Respir Cell Mol Biol 8:530-537, 1993.
7.Oury TD, L Chang, SL Marklund and JD Crapo. Immunocytochemical localization of extracellular superoxide dismutase in human lung. Lab Invest 70:889-898, 1994.
8.Folz RJ, L Peno-Green and JD Crapo. Identification of a homozygous missense mutation (Arg to Gly) in the critical binding region of the human EC-SOD gene (SOD3) and its association with dramatically increased serum enzyme levels. Human Molecular Genetics 3:2251-2254, 1994.
9.Chang L, BH Kang, JW Slot, R Vincent and JD Crapo. Immunocytochemical localization of the sites of superoxide dismutase induction by hyperoxia in rat lungs. Lab Invest 73:29-39, 1995.
10.Oury TD, JD Crapo, Z Valnickova and JJ Enghild. Human extracellular superoxide dismutase is a tetramer composed of two disulfide linked dimers: a simplified high yield purification of EC-SOD. Biochem J 317:51-57, 1996.
11.Oury TD, BJ Day and JD Crapo. EC-SOD: a regulator of nitric oxide bioavailability. Lab Invest 75:617-636, 1996.
12.Oury TD, BJ Day and JD Crapo. Extracellular superoxide dismutase in vessels and airways of humans and baboons. Free Radic Biol Med 20:957-965, 1996.
13.Day BJ and JD Crapo. A metalloporphyrin superoxide dismutase mimetic protects against paraquat-induced lung injury in vivo. Toxicol Appl Pharmacol 140:94-100, 1996.
14.Su WY, R Folz, JS Chen, JD Crapo and L Chang. Extracellular superoxide dismutase mRNA expressions in the human lung by in situ hybridization. Am J Respir Cell Mol Biol 16:162-170, 1997.
15.Folz RJ, JD Crapo and LA Peno-Green. Elevated levels of extracellular superoxide dismutase in chronic lung disease and characterization of genetic variants. Chest 111(6 Suppl):74S, 1997.
16.Folz RJ, J Guan, MF Seldin, TD Oury, JJ Enghild and JD Crapo. Mouse EC-SOD: Primary structure, tissue-specific gene expression, chromosomal localization and lung in situ hybridization. Am J Respir Cell Mol Biol 17:393-403, 1997.
17.Day BJ, I Fridovich and JD Crapo. Manganic porphyrins possess catalase activity and protect endothelial cells against hydrogen peroxide-mediated injury. Arch Biochem Biophys 347:256-262, 1997.
18.Brady TC, L Chang, BJ Day and JD Crapo. Extracellular superoxide dismutase is upregulated with inducible nitric oxide synthase after NF-kB activation. Am J Physiol (Lung Cell Mol Physiol) 273:L1002-1006, 1997.
19.Melov S, JA Schneider, BJ Day, D Hinerfeld, P Coskun, SS Mirra, JD Crapo and DC Wallace. A novel neurological phenotype in mice lacking mitochondrial manganese superoxide dismutase. Nat Genet 18:159-163, 1998.
20.Levin ED, TC Brady, EC Hochrein, TD Oury, LM Jonsson, SL Marklund and JD Crapo. Molecular manipulations of extracellular superoxide dismutase: functional importance for learning. Behavior Genetics 28:381-390, 1998.
21.Boggess KA, TD Oury, HH Kay and JD Crapo. Extracellular superoxide dismutase localization and activity within the human placenta. Placenta 19:417-422, 1998.
22.Sheng H, RD Bart, TD Oury, RD Pearlstein, JD Crapo and DS Warner. Mice overexpressing extracellular superoxide dismutase have increased resistance to focal cerebral ischemia. Neuroscience 88:185-191, 1999.
23.Day BJ, I Batinic-Haberle and JD Crapo. Metalloporphyrins are potent inhibitors of lipid peroxidation. Free Radic Biol Med 26:730-736, 1999.
24.Enghild JJ, IB Thogersen, TD Oury, Z Valnickova, P Hojrup and JD Crapo. The heparin binding domain of EC-SOD is proteolytically processed intracellularly during biosynthesis. J Biol Chem 274:14818-14822, 1999.
25.Sheng H, TC Brady, RD Pearlstein, JD Crapo and DS Warner. Extracellular superoxide dismutase deficiency worsens outcome from focal cerebral ischemia in the mouse. Neuroscience Letters 267:13-16, 1999.
26.Vlahovic G, ML Russell, RR Mercer and JD Crapo. Cellular and connective tissue changes in alveolar septal walls in emphysema. Am J Respir Crit Care Med 160:2086-2092, 1999.
27.Levin ED, FH Brucato and JD Crapo. Molecular overexpression of extracellular superoxide dismutase increases the dependency of learning and memory performance on motivational state. Behavior Genetics 30:95-100, 2000.
28.Sheng H, M Kudo, GB Macksensen, RD Pearlstein, JD Crapo and DS Warner. Mice overexpressing extracellular superoxide dismutase have increased resistance to global cerebral ischemia. Exp Neurol 163:392-398, 2000.
29.Boggess KA, HH Kay, JD Crapo, WF Moore, HB Suliman and TD Oury. Differential localization of placental extracellular superoxide dismutase as pregnancy progresses. Am J Obstet Gynecol 183:199-205, 2000.
30.Crapo JD. Respiratory structure and function. In: Cecil Textbook of Medicine, Twenty-first Edition. L Goldman and JC Bennett (eds). W.B. Saunders, Philadelphia, pp 382-387, 2000.
31.Crapo JD, AG Harmsen, MP Sherman and RA Musson. NHLBI Workshop Summary: Pulmonary immunobiology and inflammation in pulmonary diseases. American Journal of Respiratory and Critical Care Medicine 162:1983-1986, 2000.
32.Pineda JA, M Aono, H Sheng, J Lynch, JC Wellons, DT Laskowitz, RD Pearlstein, R Bowler, JD Crapo and DS Warner. Extracellular superoxide dismutase overexpression improves behavioral outcome from closed head injury in the mouse. J Neurotrauma 18:625-634, 2001.
33.Mackensen GB, M Patel, H Sheng, CL Calvi, I Batiniæ-Haberle, BJ Day, LP Liang, I Fridovich, JD Crapo, RD Pearlstein and DS Warner. Neuroprotection from delayed post-ischemic administration of a metalloporphyrin catalytic antioxidant. J Neuro Sci 21:4582-4592, 2001.
34.Oury TD, K Thakker, M Menache, L Chang, JD Crapo and BJ Day. Attenuation of bleomycin-induced pulmonary fibrosis by a catalytic antioxidant metalloporphyrin. Am J Respir Mol Cell Biol 25:164-169, 2001.
35.Bowler RP, J Arcaroli, JD Crapo, A Ross, JW Slot and E Abraham. Extracellular superoxide dismutase attenuates lung injury after hemorrhage. Am J Respir Crit Care Med 164:290-294, 2001.