Royal College of Surgeons, Ireland, 1997
Following his graduation and internship from the Royal College of Surgeons in Ireland, Dr. Leong obtained a Master degree in Medical Science (Physiology) from the University College Dublin. He then began an internal medicine residency at Albert Einstein Medical Center in Philadelphia where he also served as chief resident.
Dr. Leong is a member of the Developmental Therapeutics (Phase I clinical trials) and Gastro-Intestinal Malignancies Program. His areas of interest are investigating novel agents such as inhibitors of the insulin like growth factor 1 receptor (IGF-1R) and activators of the death receptors (DR4,DR5) and their potential use in GI malignancies. Clinically, Dr. Leong is a principal investigator or co-investigator of several Phase I and Gastro-intestinal clinical trials. In the laboratory, we are investigating the actions of these novel agents in colorectal cancers.
Leong S; Eckhardt SG, Moulder S, Warren T, Gore L, Diab S, Kurman M, Dias C, Greig G, Kurzrock. 2007. A phase I study of R1507, a human monoclonal antibody IGF-1R (insulin-like growth factor receptor) antagonist given weekly in patients with advanced solid tumors. Presented at AACR/NCI/EORTC International Conference in Molecular Targets and Cancer Therapeutics in San Francisco Oct 2007.
Kaufman SA, Pitts TM, Serkova NJ, Stephens A, Eckhardt SG, Leong S. 2007. In vitro assessment of the IGF1R inhibitor, OSI868, alone and in combination with chemotherapy, against human colorectal cancer cell lines: antiproliferative, molecular, and metabolic effects. Presented at AACR/NCI/EORTC International Conference in Molecular Targets and Cancer Therapeutics in San Francisco Oct 2007.
Leong S, Eckhardt SG, O'Bryant CL, Chow LQ, Hariharan S, Camidge R, Diab S, Maneval EC, Chao R, Lockhart AC. A Phase I Study of Sunitinib in Combination with Modified FOLFOX 6 (mFOLFOX6) Chemotherapy. Presented at the 2007 Gastrointestinal Cancers Symposium: Multidisciplinary Approaches to the Prevention, Diagnosis, and Therapy of GI Cancers, January 19-21, 2007 Orlando World Center Marriott, Orlando, Florida. Also presented at the 2006 World Congress on Gastrointestinal Cancer (June 27-30, Barcelona Spain) and at ECCO14 (Sept 22-27 2007, Barcelona Spain).