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Murry Wynes, PhD- Publications & Abstracts


2012

Publications

Christoph DC, Mascaux C, Reyna Asuncion B, Tran C, Lu X, Wynes MW, Gauler TC, Wohlschlaeger J, Theegarten D, Neumann V, Hepp R, Welter S, Stamatis G, Tannapfel A, Schuler M, Eberhardt WEE, Hirsch FR.
Folylpoly-Glutamate Synthetase Expression is associated with Tumor Response and Outcame from Pemetrexed -based Chemotherapy in Malignant Pleural Mesothelioma.
Submitted J Thorac. Oncol

Ekman S., Wynes MW, Hirsch FR.​
The mTOR Pathway in Lung Cancer and Implications for Therapy and Biomarker Analysis. 
Under revision in J Thorac Oncol

Christoph DC, Hoffmann AC, Gauler TC, Reyna Asuncion B, Loewendick H, Peglow A, Hassa B, Tran C, Wynes MW, Schuler M, Eberhardt WEE, Hirsch FR
Detection of Circulating Lung Cancer Cells with Strong Thymidylate Synthase Reactivity in the Peripheral Blood of a Patient with Pulmonary Adenocarcinoma Treated with Pemetrexed
J Thorac Oncol. 2012 Apr;7(4):766-7 PMID:22425929

Wynes MW, Konopa K, Singh S, Asuncion BR, Ranger-Moore J, Sternau A, Christoph DC, Dzidziuszko R, Jassem J, Hirsch FR
Thymidylate Synthase protein expression by IHC and gene copy number by SISH correlate and show great variability in non-small cell lung cancer.
J Thorac Oncol.

Weickhardt AJ, Doebele R, Oton AB, Lettieri J, Maxson D, Reynolds M, Brown A, Jackson M, Dy G, Adjei A, Fetterly G, Lu X, Franklin W, Varella-Garcia M, Hirsch FR, Wynes MW, Youssoufian H, Adjei A, Camidge DR.
A phase I/II study of erlotinib in combination with the anti-Insulin-Like Growth Factor-1 Receptor monoclonal antibody IMC-A12 (cixutumumab) in patients with advanced non-small cell lung cancer
J Thorac Oncol. 2012 Jan 10. PMID:22237261

Dzidziuszko R, Wynes MW, Singh S, Asuncion BR, Rnager-Moore J, Konopa K, Rzyman W, Szostakiewicz B, Jassem J, Hirsch FR
Correlation between MET Gene Copy Number by Silver In Situ Hybridization and Protein Expression by Immunohistochemistry in Non-small Cell Lung Cancer
J Thorac Oncol. 2012 jan 10.PMID:22237262

Abstracts

Christoph DC, Reyna Asuncion B, Wynes MW, Gauler TC, Wohlschlaeger J, Theegarten D, Welter S, Tran C, Hassan B, Loewendick H, Peglow A, Schuler M, Eberhardt WEE, Hirsch FR. Folylpoly-γ-glutamate synthetase and thymidylate synthase are associated with clinical outcome from pemetrexed-based therapy in advanced non-small cell lung cancer (NSCLC). Abstract 1713 Poster presentation at the AACR Annual Meeting. March 31 - April 3, 2012, Chicago, IL, USA.

Christoph DC, Reyna Asuncion B, Wynes MW, Gauler TC, Wohlschlaeger J, Theegarten D, Welter S, Tran C, Hassan B, Loewendick H, Peglow A, Schuler M, Eberhardt WEE, Hirsch FR. Folylpoly-glutamate synthetase and thymidylate synthase are associated with clinical outcome from pemetrexed-based therapy in advanced non-small cell lung cancer (NSCLC). Poster B6. Poster presentation at the AACR-IASLC Joint Conference on Molecular Origins of Lung Cancer: Biology, Therapy, and Personalized Medicine. January 8-11, 2012, San Diego, CA, USA.

2011

Publications

Salido M,, Pijuan L, Martínez-Avilés L, Galván AB, Cañadas I, Rovira A, Zanui M, Martínez A, Longarón R, Sole F, Serrano S, Bellosillo B, Wynes MW, Albanell J, Hirsch FR, Arriola E.
Increased ALK Gene Copy Number and Amplification are Frequent in Non-small Cell Lung Cancer

J Thorac Oncol. 2011 Jan;6(1):21 PMID:21107285

Mascaux C, Wynes MW, Kato Y, Tran C, Asuncion BR, Zhao JM, Gustavson M, Rangere-Moore J, Gaire F, Matsubayashi J, Nagao T, Yoshida K, Ohira T, Ikeda N, Hirsch FR.
EGFR Protein Expression in Non-Small Cell Lung Cancer Predicts Response to an EGFR tyrosine kinase inhibitor- A novel antibody immunochistochemistry or AQUA technology.
Clinic Cancer Dec 15;17(24):7796-807. PMID:21994417

Abstracts

Kato Y., Mascaux C., Wynes M.W., Reyna Asuncion B., Tran C., Yoshida K., Matsubayashi J., Nakajima E., Ohira T., Nagao T., Furukawa K., Ikeda N. Hirsch F.R. The role of IGF-1R in EGFR TKI resistance in NSCLC using IHC and AQUA technology. 2011 ASCO Annual Meeting, Chicago, IL, USA, June 2011. J Clin Oncol 2011, 29, suppl, abstract 10556.

Christoph D.C., Mascaux C., Wynes M.W., Reyna Asuncion B., Wohlschlaeger J., Theegarten D., Gauler T.C., Schuler M.H., Eberhardt W.E.E., Hirsch F.R. Predictive value of thymidylate synthase and folylpoly-glutamate synthetase for clinical benefit from pemetrexed in malignant pleural mesothelioma. 2011 ASCO Annual Meeting, Chicago, IL, USA, June 2011. J Clin Oncol 2011, 29, suppl, abstract 7024.

Wynes M.W., Kato Y., Mascaux C., Reyna Asuncion B.G., Sanchez S.A., Matsubayashi J., Yoshida K., Nagao T., Furukawa K., Ikeda N., Hirsch F.R. I mmunohistochemistry using an EGFR internal domain-specific antibody predicts response and outcome to an EGFR tyrosine kinase inhibitor. 14th World Conference on Lung Cancer, Amsterdam, The Netherlands, July 2011, WCLC proceeding 2011, MO10.10.

Kato Y., Wynes M.W., Mascaux C., Reyna Asuncion B., Tran C., Yoshida K., Matsubayashi J., Nakajima E., Ohira T., Nagao T., Furukawa K., Ikeda N. Hirsch F.R. IGF-1R as a predictive marker for EGFR TKI (Gefitinib) resistance in Non Small Cell Lung Cancer using IHC and AQUA technology. 14th World Conference on Lung Cancer, Amsterdam, The Netherlands, July 2011, WCLC proceeding 2011, O39.03.

2010

Publications

Mascaux C, Peled N, Garg K, Kato Y, Wynes MW, Hirsch FR.
Early detection and screening of lung cancer.
Expert Rev Mol Diagn. 2010 Sep;10(6):799-815. PMID:20843203

Hirsch FR, Wynes MW, Gandara DR, Bunn PA Jr.
The tissue is the issue: personalized medicine for non-small cell lung cancer.
Clin Cancer Res. 2010 Oct 15;16(20):4909-11. PMID:20926402

Kato Y, Peled N, Wynes MW, Yoshida K, Pardo M, Mascaux C, Ohira T, Tsuboi M, Matsubayashi J, Nagao T, Ikeda N, Hirsch FR.
Novel epidermal growth factor receptor mutation-specific antibodies for non-small cell lung cancer: immunohistochemistry as a possible screening method for epidermal growth factor receptor mutations.
J Thorac Oncol. 2010 Oct;5(10):1551-8 PMID:20697298

Badzio A, Wynes MW, Dziadziuszko R, Merrick DT, Pardo M, Rzyman W, Kowalczyk A, Singh S, Ranger-Moore J, Manriquez G, Gaire F, Jassem J, Hirsch FR.
Increased insulin-like growth factor 1 receptor protein expression and gene copy number in small cell lung cancer. 
J Thorac Oncol. 2010 Dec;5(12):1905-11. PMID:21124078

Abstracts

Wynes M.W., Mascaux C., Kato Y., Reyna-Asuncion B., Zhao J., Powell W., Ranger-Moore J., Yoshida K., Ikeda N., Hirsch F.R. Prediction of tesponse to Gefitinib in NSCLC by EGFR protein expression is increased by a novel antibody and the use of AQUA technology. Chicago Multidisciplinary Symposium in Thoracic Oncology, Chicago, USA, December 2010, S504, abstract 10

Kato Y., Peled N., Yoshida K., Wynes M. W., Pardo M., Mascaux C., Tsuboi M., Ohira T., Ikeda N., Hirsch F.R. Immunohistochemistry detection of epidermal growth factor receptor (EGFR) exons 19 and 21 mutations in non-small cell lung cancer (NSCLC) using novel mutation specific antibodies., 2010 ASCO Annual Meeting, Chicago, IL, USA, June 2010, ASCO meeting proceedings 2010, page733s abstract 10542.

 
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