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Bernadette Reyna-Asuncion, M.D.- Publications & Abstracts


2012

Publications

Christoph DC, Mascaux C, Reyna Asuncion B, Tran C, Lu X, Wynes MW, Gauler TC, Wohlschlaeger J, Theegarten D, Neumann V, Hepp R, Welter S, Stamatis G, Tannapfel A, Schuler M, Eberhardt WEE, Hirsch FR.
Folylpoly-Glutamate Synthetase Expression is associated with Tumor Response and Outcame from Pemetrexed -based Chemotherapy in Malignant Pleural Mesothelioma.
Submitted J Thorac. Oncol

Christoph DC, Hoffmann AC, Gauler TC, Reyna Asuncion B, Loewendick H, Peglow A, Hassan B, Tran C, Wynes MW, Schuler M, Eberhardt WEE, Hirsch FR
Detection of Circulating Lung Cancer Cells with Strong Thymidylate Synthase Reactivity in the Peripheral Blood of a Patient with Pulmonary Adenocarcinoma Treated with Pemetrexed
J Thorac Oncol. 2012 Apr;7(4):766-7 PMID:22425929

Wynes MW, Konopa K, Singh S, Asuncion BR, Ranger-Moore J, Sternau A, Christoph DC, Dziadziuszko R, Jassem J, Hirsch FR
Thymidylate Synthase protein expression by IHC and gene copy number by SISH correlate and show great variability in non-small cell lung cancer.
J Thorac Oncol.

Dziadziuszko R, Wynes MW, Singh S, Asuncion BR, Ranger-Moore J, Konopa K, Rzyman W, Szostakiewicz B, Jassem J, Hirsch FR
Correlation between MET gene copy number by Silver In-Situ Hybridization and Protein Expression by Immunochistochemistry in non-small cell lung cancer.
J Thorac Oncol. 2012 Jan 10. PMID: 22237262

Abstracts

Christoph DC, Reyna Asuncion B, Wynes MW, Gauler TC, Wohlschlaeger J, Theegarten D, Welter S, Tran C, Hassan B, Loewendick H, Peglow A, Schuler M, Eberhardt WEE, Hirsch FR. Folylpoly-γ-glutamate synthetase and thymidylate synthase are associated with clinical outcome from pemetrexed-based therapy in advanced non-small cell lung cancer (NSCLC). Abstract 1713 Poster presentation at the AACR Annual Meeting. March 31 - April 3, 2012, Chicago, IL, USA.

Christoph DC, Reyna Asuncion B, Wynes MW, Gauler TC, Wohlschlaeger J, Theegarten D, Welter S, Tran C, Hassan B, Loewendick H, Peglow A, Schuler M, Eberhardt WEE, Hirsch FR. Folylpoly-glutamate synthetase and thymidylate synthase are associated with clinical outcome from pemetrexed-based therapy in advanced non-small cell lung cancer (NSCLC). Poster B6. Poster presentation at the AACR-IASLC Joint Conference on Molecular Origins of Lung Cancer: Biology, Therapy, and Personalized Medicine. January 8-11, 2012, San Diego, CA, USA.

 

2011

Publications

Mascaux C. Wynes M.W., Yasufumi K., Tran C., Reyna Asuncion B. Zhao J., Gustavson M., Ranger-Moore J., Gaire F.,  Matsubayashi J., Nagao T., Yoshida K., Ohira T., Ikeda N., Hirsch F.R.
EGFR protein expression in non-small cell lung cancer predicts response to an EGFR tyrosine kinase inhibitor - A novel antibody for immunohistochemistry or AQUA technology.
Clin Cancer Res. 2011 Dec 15;17(24):7796-807. PMID:21994417

Abstracts

Kato Y., Wynes M.W., Mascaux C., Reyna Asuncion B., Tran C., Yoshida K., Matsubayashi J., Nakajima E., Ohira T., Nagao T., Furukawa K., Ikeda N. Hirsch F.R
IGF-1R as a predictive marker for EGFR TKI (Gefitinib) resistance in Non Small Cell Lung Cancer using IHC and AQUA technology.
14th World Conference on Lung Cancer, Amsterdam, The Netherlands, July 2011, WCLC proceeding 2011, O39.03.

Wynes M.W., Kato Y., Mascaux C., Reyna Asuncion B.G., Sanchez S.A., Matsubayashi J., Yoshida K., Nagao T., Furukawa K., Ikeda N., Hirsch F.R.
Immunohistochemistry using an EGFR internal domain-specific antibody predicts response and outcome to an EGFR tyrosine kinase inhibitor.

14th World Conference on Lung Cancer, Amsterdam, The Netherlands, July 2011, WCLC proceeding 2011, MO10.10.

Christoph D.C., Mascaux C., Wynes M.W., Reyna Asuncion B., Wohlschlaeger J., Theegarten D., Gauler T.C., Schuler M.H., Eberhardt W.E.E., Hirsch F.R. Predictive value of thymidylate synthase and folylpoly-glutamate synthetase for clinical benefit from pemetrexed in malignant pleural mesothelioma. 2011 ASCO Annual Meeting, Chicago, IL, USA, June 2011. J Clin Oncol 2011, 29, suppl, abstract 7024.

Kato Y., Mascaux C., Wynes M.W., Reyna Asuncion B., Tran C., Yoshida K., Matsubayashi J., Nakajima E., Ohira T., Nagao T., Furukawa K., Ikeda N. Hirsch F.R. The role of IGF-1R in EGFR TKI resistance in NSCLC using IHC and AQUA technology. 2011 ASCO Annual Meeting, Chicago, IL, USA, June 2011. J Clin Oncol 2011, 29, suppl, abstract 10556. 

2010

Abstracts

Wynes M.W., Mascaux C., Kato Y., Reyna-Asuncion B., Zhao J., Powell W., Ranger-Moore J., Yoshida K., Ikeda N., Hirsch F.R. Prediction of tesponse to Gefitinib in NSCLC by EGFR protein expression is increased by a novel antibody and the use of AQUA technology. Chicago Multidisciplinary Symposium in Thoracic Oncology, Chicago, USA, December 2010, S504, abstract 10.

 

 
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