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Adriana Weinberg, MD

Professor, Pediatrics, Medicine and Pathology



                                  Phone: 303-724-4922


                                  Address:  12700 E. 19th Box B168, Aurora, CO 80045

Medical School
University of Sao Paulo School of Medicine,
Sao Paulo, Brazil

Infectious Diseases, Hospital das Clinicas, University of Sao Paulo School of Medicine,
Sao Paulo, Brazil

Infectious Diseases, Stanford University School of Medicine,
Stanford, California

Immune restoration in HIV-infected patients has been the object of Adrianna Weinberg, MD studies for several years. As such, I established virologic correlates of immune reconstitution in children and adults, and identified immune correlates of protection against CMV infection in HIV-infected patients on HAART. I recently described an inhibitory mechanism of cellular immunity operative in HIV-infected patients, but not in healthy individuals. This is the current object of more in-depth studies at sub-cellular level. I developed several lines of investigation of CMV-specific immunity in transplant patients, including the following: impact of CMV infection on graft rejection;immune restoration in bone marrow transplant recipients and immune correlates of protection against CMV infections; use of dendritic cells for establishment of CMV-specific immunity in stem cell and cord blood transplant recipients.

1) Weinberg A, Bloch KC, Li S, Tang Y-W, Palmer M, Tyler KL. 2005. Dual infections of the central nervous system with Epstein-barr virus. J Infect Dis, 191(2): 234-7.

2) Carey VJ, Pahwa S, and Weinberg A. 2005. Reliability of CD4 measurs in HIV+ children: Implications for definition of immunologic response to HAART. Clin and Diagn Lab Immunol, 12: 640-3.

3) Wyles DL, Patel A, Madinger N, Krause PR, Weinberg A. 2005. Development of herpes simplex virus disease in patients receiving cidofovir. Clin Infect Dis, 41: 676-80.

4) Weinberg A, Tierney C, Kendall MA, et al. 2006. Cytomegalovirus-specific immunity and protection against viremia and disease in HIV-infected patients in the era of HAART. J Infect Dis, 193:488-93.

5) Weinberg A, Gona P, Nachman SA, et al. 2006. Antibody responses to hepatitis A virus vaccine among HIV-infected children with evidence of immunologic reconstitution on antiretroviral therapy. J Infect Dis, 193:302-11.

6) Weinberg A, Wiznia AA, LaFleur BJ, et al. 2006. Cytomegalovirus-specific cell-mediated immunity in HIV-infected children on HAART. AIDS Res Hum Retrovirus, 22:283-8.

7) Weinberg A, Horslen SP, Kauffman SS, Jesser R, DeVoll-Zabrocki A, Fleckten BL, Kochanowicz S, Seipel KR, Levin MJ. 2006. Safety and immunogenicity of varicella-zoster virus vaccine in pediatric liver and intestine transplant recipients. Am J Transplant, 6:565-8.

8) Jesser RD, Li S, and Weinberg A. 2006. Regulatory T cells generated during cytomegalovirus in vitro stimulation of mononuclear cells from HIV-infected individuals on HAART correlate with decreased lymphocyte proliferation. Virol, 352:408-17.

9) Weinberg A, Leary JJ, Sarisky RT, and Levin MJ. 2007. Factors that affect in vitro measurement of the susceptibility of herpes simplex virus to nucleoside analogues. J Clin Virol, 38:139-45.

10) Enomoto LM, Kloberdanz KJ, Mack DG, Elizabeth D, and Weinberg A. 2007. Ex vivo effect of estrogen and progesterone compared with dexamethasone on cell-mediated immunity of HIV-infected and uninfected subjects. J Acquir Immune Defic Syndr, In press.