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Irene E. Schauer, M.D., Ph.D


Assistant Professor of Medicine

 

As a clinician scientist at the VA, my mission is to provide state-of-the-art Endocrinology care while also pursuing clinical research with the potential to impact patient care. My research addresses the role of insulin resistance and fatty acid elevation in increased cardiovascular risk with the ultimate goal of identifying novel therapeutic targets for cardiovascular risk management. I am studying the impact of insulin sensitizers with different mechanisms on cardiovascular function and mitochondrial function and oxidant generation. I have a particular interest in type 1 diabetes where cardiovascular disease risk has improved very little over the years and where insulin resistance is poorly understood and hence relatively difficult to target therapeutically. I am also interested in sex-based differences in the effect of diabetes on cardiovascular risk and function, particularly on the loss of premenopausal protection in women with diabetes. I bring a strong basic research background and clinical research skills to bear on these questions and plan to take these studies “to the bedside” in order to improve diabetes-associated cardiovascular disease risk and mortality.​​

  • Diabetes
  • Insulin Resistance
  • Fatty Acids
  • Vascular Biology
  • Exercise

  1. Hepatic and skeletal muscle insulin resistance in Type 1 diabetes. (2012)
    Bergman BC, D Howard, IE Schauer, DM Maahs, JK Snell-Bergeon, RH Eckel, L Perreault, and M Rewers.
    JCEM: 2012 May;97(5):1663-72.
  2. Adiponectin Dysregulation and Insulin Resistance in Type 1 Diabetes. (2012)
    Pereira RI, JK Snell-Bergeon, C Erickson, IE Schauer, B Bergman, M Rewers, and DM Maahs. JCEM: 2012 Apr;97(4):E642-7.
  3. Insulin resistance, defective insulin-mediated fatty acid suppression, and coronary artery calcification in subjects with and without type1 diabetes: the CACTI study.(2011)
    Schauer, IE, Snell-Bergeon JK, Bergman BC, Maahs DM, Kretowski A, Eckel RH, Rewers M.
    Diabetes 60(1): 306.
  4. Association of insulin sensitivity to lipids across the lifespan in people with Type 1 diabetes. (2011)
    Maahs DM, Nadeau K, Snell-Bergeon JK, Schauer I, Bergman B, West NA, Rewers M, Daniels SR, Ogden LG, Hamman RF, Dabelea D.
    Diabet Med 28(2):148-55.
  5. Glycaemic variability is associated with coronary artery calcium in men with Type 1 diabetes: the Coronary Artery Calcification in Type 1 Diabetes study. (2010)
    Snell-Bergeon JK, Roman R, Rodbard D, Garg S, Maahs DM, Schauer IE, Bergman BC, Kinney GL, Rewers M.
    Diabet Med 27(12): 1436.
  6. Lipoprotein Subfraction Cholesterol Distribution is Pro-Atherogenic in Women with Type 1 Diabetes and Insulin Resistance. (2010)
    Maahs, DM, JE Hokanson, H Wang, GL Kinney, JK Snell-Bergeon, A East, B Bergman, IE Schauer, M Rewers, RH Eckel.
    Diabetes 59(7): 1771.
  7. Divergent impact of LDL and oxidized LDL on CREB activation versus CREB-mediated downregulation. (2010)
    Schauer, IE, L Knaub, M Lloyd, C Gliwa, M Hockin, J Gunter, TO McDonald, KD O’Brien, and JEB Reusch.
    ATVB 30(4): 733-41.
  8. Non-esterified fatty acid exposure activates protective and mitogenic pathways in vascular smooth muscle cells by alternate signaling pathways. (2009)
    Schauer, IE, PA Watson, J E-B. Reusch.
    Metabolism 58: 319-327.
​​
  • Diabetes
  • Insulin Resistance
  • Cardiovascular Disease
  • General Endocrinology

Graduate Schools
PhD, University of California, Berkeley(1985)
MD, University of Colorado School of Medicine (2000)

Undergraduate Schools
BS, University of Tennessee, Knoxville (1975)

Internships
University of COlorado (University Hospital) Program (2001)

Residency Program
University of Colorado (University Hospital) Program, Internal Medicine (2003)

Fellowships
University of Colorado (University Hospital) Program, Internal Medicine - Endocrinology, Diabetes, and Metabolism (2007)

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​Title

Leslie Knaub Senior ​Professional Research Assistant
Nick Birdsey ​Professional Research Assistant
Leah Herlache ​Professional Research Assistant
Nathaniel Solis Professional Research Assistant