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The central focus of Dr. Pugazhenthi's research is molecular mechanism of cell death. Common pathological mechanisms are being studied in two disease models, namely, loss of insulin-producing beta cells in diabetes and neurodegeneration in Alzheimer’s brain. Transcriptional regulation of cytoprotective genes are examined in cultured human islets and in human neural stem-derived neurons. The long-term goal is to enhance cell survival through modulation of transcription factors under conditions of oxidative stress and inflammation.
Graduate SchoolsPh.D., University of Delhi, India (1986)M.S., University of Madras, India (1975)Undergraduate SchoolB.S., University of Madras, India (1972)
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