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University of Colorado Department of Biochemistry and Molecular Genetics

Biochemistry and Molecular Genetics
 

Hodges Lab Publications


Publications are grouped into the following six topic areas:​

  1. Immunology and the Development of Synthetic Peptide Vaccines against Bacterial and Viral Pathogens
  2. Development of Antimicrobial Peptides and Peptide Interactions with Lipid Bilayers
  3. Protein Folding, Stability and Design:  alpha-helices and coiled-coils
  4. Calcium Binding Proteins and Regulation of Muscle Contraction
  5. Methodology Development: HPLC, Capillary Electrophoresis and Synthesis
  6. New topic here
2015-2019
  1. Jiang, Z., L. Gera, C.T. Mant, B. Hirsch, Z. Yan, J. Shortt, D.D. Pollock Z. Qian, K. Holmes and R.S. Hodges. Platform technology to generate broadly cross-reactive antibodies to α-helical epitopes in hemagglutinin proteins from Influenza A viruses. Biopolymers Peptide Science 106: 144-159 (2016)

2010-2014
  1. Hartsock, W.J., C. Hackbarth and R.S. Hodges. Antiadhesion synthetic consensus sequence peptide-based vaccines for Pseudmonas aeruginosa. In Handbook of Biologically Active Peptides, 2nd edition, (A.J. Kastin, Editor in Chief) Chapter 77, pp. 563-570 (2013)
  2. Yan, Z., W.J. Hartsock, Z. Qian, K.V. Holmes and R.S. Hodges. Strategies for designing peptide immunogens to elicit α-helical conformation specific antibodies reactive with native proteins. In “Small Wonders: Peptides for Disease Control” (K. Rajasekaran, J.W. Cary and J. Jaynes, Eds.) ACS Symposium Series, Chapter 6, pp. 93-136 (2012)
  3. Hackbarth, C. and R.S. Hodges.  Synthetic Peptide Vaccine Development: Designing Dual Epitopes into a Single Pilin Peptide Immunogen Generates Antibody Cross-reactivity between Two Strains of Pseudomonas aeruginosa.  Chem. Biol. & Drug Design 76: 293-304 (2010).  (Journal Cover Figure)​

2005-2009
  1. Kao, D. and R.S. Hodges.  Advantages of a synthetic peptide immunogen over a protein immunogen in the development of an anti-pilus vaccine for Pseudomonas aeruginosa.  Chemical Biology and Drug Design 74: 33-42 (2009).
  2. Pimentel, T.A.P.F., Z. Yan, S.A. Jeffers, K.V. Holmes, R.S. Hodges and P. Burkhard.  Peptide nanoparticles as novel immunogens:  Design and analysis of a prototypic Severe Acute Respiratory Syndrome vaccine.  Chem. Biol. Drug Design 73: 53-61 (2009).
  3. Yu, B., E. Davis, R.S. Hodges, R.T. Irvin and D.Y. Li.  Surface nanocrystallization of stainless steel for reduced biofilm adherence.  Nanotechnology 19 (doi: 335101) 8 pp. (2008).
  4. Yu, B., C.L. Giltner, E.J. van Schaik, D.L. Bautista, R.S. Hodges, G.F. Audette, D.Y. Li, and R.T. Irvin.  A noval biometallic interface:  High affinity tip-associated binding by pilin-derived protein nanotubes.  J. Bionanoscience  1: 73-83 (2007).
  5. Kao, D., M.E. Churchill, R.T. Irvin and R.S. Hodges. Animal protection and structural studies of a consensus sequence vaccine targeting the receptor binding domain of the type IV pilus of Pseudomonas aeruginosa.  J. Mol. Biol. 374: 426-442 (2007).
  6. Howard, M.W., B. Tripet, M.G. Jobling, R.K. Holmes, K.V. Holmes and R.S. Hodges.  Dissection of the fusion machine of SARS-coronavirus Adv. Exp. Med. Biol. 581:319-322 (2006).
  7. Yan, Z., B. Tripet and R.S. Hodges. Biophysical Characterization of HRC Peptide Analogs Interaction with Heptad Repeat Regions of the  SARS-Coronavirus Spike Fusion Protein Core. J. Structural Biology 155:  162-175 (2006).
  8. Tripet, B., D. Kao, S. Jeffers, K. Holmes and R.S. Hodges.  Template-based Coiled-coil antigens elicit neutralizing antibodies to the SARS-Coronavirus.  J. Structural Biology 155:  176-194 (2006).
  9. Helmke, S.M., S.M. Lu, M. Harmon, J.W. Glasford, T.D. Larsen, S.C. Kwok, R.S. Hodges and M.B. Perryman.  Myotonic dystrophy protein kinase monoclonal antibody generation from a coiled-coil template.  J. Mol. Recognition 19: 215-226 (2006).
  10. Kao, D., and R.S. Hodges.  Anti-adhesin synthetic peptide consensus sequence vaccine and antibody therapeutic for Pseudomonas aeruginosa.  In Handbook of Biologically Active Peptides (A.J. Kastin, Ed.) Elsevier Press, Chapter 73, pp. 507-514 (2006).
  11. Giltner, C.L., E.J. Van Schaik, G.F. Audette, D. Kao, R.S. Hodges, D.J. Hassett and R.T. Irvin. The Pseudomonas aeruginosa Type IV Pilin Receptor Binding Domain Functions as an Adhesin for binding to both biotic and abiotic surfaces. Molecular Microbiology 59: 1083-1096 (2006).
  12. Ramon, S.K., D. Kao, D. Tropel, A. Graff, G. Machaidze, R.S. Hodges and P. Burkhard.  Peptide based nanoparticles as a platform for vaccine design.  Nanotech 2005 Vol. 1 Chapter 2: Medical Applications pp. 47-50.

2000-2004
  1. Tripet, B., M.W. Howard, M. Jobling, R.K. Holmes, K.V. Holmes, and R.S. Hodges. Structural characterization of the SARS-Coronavirus Spike Fusion Protein Core. J. Biol. Chem. 279: 20836-20849 (2004).
  2. Cachia, P.J., D. Kao and R.S. Hodges. Synthetic peptide vaccine development:  Measurement of polyclonal antibody affinity and cross-reactivity using a new peptide capture and release system for surface plasmon resonance spectroscopy. J. Mol. Recognition 17: 540-557 (2004).
  3. Cachia, P.J. and R.S. Hodges. Synthetic peptide vaccine and antibody therapeutic development: Prevention and treatment of Pseudomonas aeruginosa. Peptide Science (Biopolymers) 71: 141-168 (2003).
  4. Lu, S.M. and R.S. Hodges. A de novo designed template for generating conformation specific antibodies which recognize a-helices in proteins. J. Biol. Chem. 277: 23515-23524 (2002).
  5. Sokol, P.A., C. Kooi, R.S. Hodges, P. Cachia and D.E. Woods.  Immunization with a Pseudomonas aeruginosa elastase peptide reduces severity of experimental lung infections due to Pseudomonas aeruginosa or Busrkholderi cerpacia.  J. Infectious Diseases 181:  1682-1692 (2000).

1995-1999
  1. Collinson, S.K., J.M.R. Parker, R.S. Hodges, W.W. Kay.  Models of the AgfA Fimbrin Subunit of Salmonella Thin Aggregative Fimbriae.  J. Mol. Biol. 290:  741-756 (1999).
  2. Cachia, P.J., L.M.G. Glasier, R.R.W. Hodgins, W.Y. Wong, R.T. Irvin and R.S. Hodges.  The use of synthetic peptides in the design of a consensus sequence vaccine for Pseudomonas aeruginosa.  J. Peptide Research 52:  289-299 (1998).
  3. Bishop, R.E., B.K. Leskiw, R.S. Hodges, C.M. Kay and J.H. Weiner.  The entericidin locus governs stationary phase autolysis of Escherichia coli and its implications for programmed bacterial cell death.  J. Mol. Biol  280:  583-596 (1998).
  4. Jones, D.H., R.S. Hodges, R.A. Barber and C.W.M. Grant.  Pilin C-terminal peptide binds Asialo-GM, in liposomes:  a 2H NMR study.  Protein Science 6 2459-2461 (1997).
  5. Campbell, A.P., D.L. Bautista, B. Tripet, W.Y. Wong, R.T. Irvin, R.S. Hodges and B.D. Sykes.  Solution Secondary Structure of a Bacterially Expressed Peptide from the Receptor Binding Domain of Pseudomonas aeruginosa  Pili Strain PAK:  a Heteronuclear Multidimensional NMR Study.  Biochem. 36:  12791-12801 (1997).
  6. Campbell, A.P., W.Y. Wong, M.E. Houston, Jr., F. Schweizer, P.J. Cachia, R.T. Irvin, O. Hindsgual, R.S. Hodges and B.D. Sykes.  Interaction of the receptor binding domains of Pseudomonas aeruginosa pili strains PAK, PAO, KB7 and P1 to a cross-reactive antibody and receptor analog:  Implications for synthetic vaccine design.  J. Mol. Biol. 267:  382-402 (1997).
  7. Kooi, C., R.S. Hodges and P.A. Sokol.  Identification of neutralizing epitopes on and effects of cross-reactions on other thermolysin-like proteases.  Infect. Immun. 65:  472-477 (1997).
  8. Lee, K.K., L. Yu, D.L. Macdonald, W. Paranchych, R.S. Hodges and R.T. Irvin.  Anti-adhesin antibodies that recognize a receptor-binding motif (adhesintope) inhibit pilus/fimbrial-mediated adherence of Pseudomonas aeruginosa and Candida albicans to asialo-GM, receptors and human buccal epithelial cell surface receptors.  Can. J. Micro. 42:  479-486 (1996).
  9. Campbell, A.P., H.B. Sheth, R.S. Hodges and B.D. Sykes.  NMR solution structure of the receptor binding domain of Pseudomonas aeruginosa pili strain P1:  Identification of a β-turn.  Int. J. Pept. Pro. Res. 48:  539-552 (1996).
  10. Yu, L., K.K. Lee, W. Paranchych, R.S. Hodges and R.T. Irvin.  Use of synthetic peptides to confirm that the Pseudomonas aeruginosa PAK pilus adhesin and the Candida albicans fimbrial adhesin possess a homologous receptor-binding domain.  Molecular Microbiology 19:  1107-1116 (1996).
  11. Campbell, A.P., C. McInnes, R.S. Hodges and B.D. Sykes.  Comparison of NMR solution structures of the receptor binding domains of Pseudomonas aeruginosa pili strains PAO, KB7, and PAK:  Implications for receptor binding and synthetic vaccine design.  Biochemistry 34:  16255-16268 (1995).
  12. Wong, W.Y., A.P. Campbell, C. McInnes, B.D. Sykes, W. Paranchych, R.T. Irvin and R.S. Hodges.  Structure-function analysis of the adherence-binding domain on the pilin of Pseudomonas aeruginosa strain PAK and KB7.  Biochemistry 34:  12963-12972 (1995).
  13. Sheth, H.B., L.M.G. Glasier, N.W. Ellert, P. Cachia, W. Kohn, K.K. Lee, W. Paranchych, R.S. Hodges and R.T. Irvin.  Development of an anti-adhesive vaccine for Pseudomonas aeruginosa targeting the C-terminal of the pilin structural protein.  Biomedical Peptides, Proteins and Nucleic Acids 1:  141-148 (1995).
  14. Lee, K.K., W.Y. Wong, H.B. Sheth, R.S. Hodges, W. Paranchych and R.T. Irvin.  Use of synthetic peptides in characterization of microbiol adhesins.  Methods in Enzymology  253:  115-131 (1995).

1990-1994
  1. Yu, L., K.K. Lee, R.S. Hodges, W. Paranchych and R.T. Irvin.  Adherence of Pseudomonas aeruginosa and Candida albicans to glycosphingolipid (asialo-GM1) receptors is achieved by a conserved receptor-binding domain present on their adhesins.  Infect. Immun. 62:  5213-5219 (1994).
  2. Wong, W.Y., H.B. Sheth, R.T. Irvin and R.S. Hodges.  Enhancing strain cross-reactivity of a synthetic peptide vaccine for pseudomonas aeruginosa.  Pediatric Pulmonology Supplement 10:  157-158 (1994).
  3. Wong, W.Y., H.B. Sheth, A. Holm, R.S. Hodges and R.T. Irvin.  Representative Combinatorial Peptide Libraries:  An approach to reduce both synthesis and screening effort.  In "Generation and Selection of Random Arrays of Peptides" (Ed. P. Strop), as part of Methods:  A companion to Methods in Enzymology  (J.N. Albelson and M.I. Simon [Eds-in-Chief], Academic Press) 6:  404-410 (1994).
  4. McInnes, C., C.M. Kay, R.S. Hodges and B.D. Sykes.  Conformation of differences between cis and trans proline isomers of a peptide antigen representing the receptor binding domain of Pseudomonas aeruginosa as studied by 1HNMR.  Biopolymers 34:  1221-1230 (1994).
  5. Yu, L.,  K.K. Lee, H.B. Sheth, P. Lane-Bell, G. Srivastava, O. Hindsgual, W. Paranchych, R.S. Hodges and R.T. Irvin.  Fimbrial-mediated adherence of candida albicans to glycosphingolipid receptors on human buccal epithelial cells.  Infect. Immun. 62:  2843-2848 (1994).
  6. Yu, L., K.K. Lee, K. Ens, P.C. Doig, M.R. Carpenter, R.S. Hodges, W. Paranchych and R.T. Irvin.  Partial characterization of a candida albicans fimbrial adhesin.  Infect. Immun. 62:  2834-2842 (1994).
  7. Sheth, H.B., K.K. Lee, W.Y. Wong, G. Srivastava, O. Hindsgual, R.S. Hodges, W. Paranchych and R.T. Irvin.  The pili of pseudomonas aeruginosa strains PAK and PAO bind specifically to the carbohydrate sequence β-Gal NAc (1-4) β-Gal found in glycolipids asialo-GM1 and asialo-GM2.  Molecular Microbiology  11:  715-723 (1994).
  8. Lee, K.K., H.B. Sheth, W.Y. Wong, R. Shelburne, W. Paranchych, R.S. Hodges, C.A. Lingwood, H. Krivan and R.T. Irvin.  The binding of Pseudomonas aeruginosa pili to glycosphingolipids is a tip-associated event involving the C-terminal region of the structural pilin subunit.  Molecular Microbiology  11:  705-713 (1994).
  9. McInnes, C., F.D. Sonnichsen, C.M. Kay, R.S. Hodges and B.D. Sykes.  NMR solution structure and flexibility of a peptide antigen representing the receptor binding domain of Pseudomonas aeruginosa.  Biochemistry 32:  13432-13440 (1993).
  10. Murphy, R.A., A. Acheson, R.S. Hodges, J. Haskins, C. Richards, E. Reklow, V. Chlumechy, P.A. Barker, R.F. Alderson and R.M. Lindsay.  Immunological relationships of NGF, BDNF and NT-3:  Functional inhibition by antibodies to NGF and NGF peptides.  J. Neuroscience  13:  2853-2862 (1993).
  11. Wong, W.Y., R.T. Irvin, W. Paranchych and R.S. Hodges.  Antigen-antibody interactions:  Elucidation of the epitope and strain-specificity of a monoclonal antibody directed against the pilin protein adherence binding domain of Pseudomonas Aeruginosa Strain K.  Protein Science  1:  1308-1318 (1992).
  12. Parker, J.M.R. and R.S. Hodges.  Prediction of surface and interior regions in proteins - Part 2:  Predicting secondary structure in regions bound by surface exposed regions.  Peptide Research, 4: 355-363 (1991).
  13. Parker, J.M.R. and R.S. Hodges.  Prediction of surface and interior regions in proteins - Part I:  Linear tripeptide sequences identify structural boundaries in proteins.  Peptide Research , 4: 347-354 (1991).
  14. Zubrzycka-Gaarn, E.E., O.F. Hutter, G. Karpati, H.J. Klamut, D.E. Bulman, R.S. Hodges, R.G. Worton and P.N. Ray.  Dystrophin is tightly associated with the sarcolemma of mammalian skeletal muscle fibres.  Experimental Cell Research  192: 278-288 (1991).
  15. Lee, K.K., W. Paranchych and R.S. Hodges.  Crossreactive and strain-specific antipeptide antibodies to Pseudomonas aeruginosa PAK and PAO pili.  Infection and Immunity  58: 2727-2732 (1990).
  16. Kohl, S., N.C.J. Strynadka, R.S. Hodges and L. Pereira.  Analysis of the role of antibody-dependent cellular cytotoxic antibody activity in murine neonatal Herpes Simplex Virus infection with antibodies to synthetic peptides of glycoprotein D and monoclonal antibodies to glycoprotein B.  J. Clinical Investigation  86: 273-278 (1990).
  17. Doig, P., P.A. Sastry, R.S. Hodges, K.K. Lee, W. Paranchych and R.T. Irvin.  Inhibition of pilus mediated adhesion of Pseudomonas aeruginosa to human buccal epithelial cells by monoclonal antibodies directed against pili.  Infect. Immun. 58: 124-130 (1990).

1985-1989
  1. Lee, K.K., P. Doig, R.T. Irvin, W. Paranchych and R.S. Hodges.  Mapping the surface of Pseudomonas aeruginosa PAK pilin:   The importance of the C-terminal region for adherence to human buccal epithelial cells.  Molecular Microbiology  3: 1493-1499 (1989).
  2. Irvin, R.T., P. Doig, K.K. Lee, P.A. Sastry, W. Paranchych, T. Todd and R.S. Hodges.  Characterization of the Pseudomonas aeruginosa pilus adhesin: Confirmation that the pilin structural protein subunit contains a human epithelial cell binding domain.  Infect. Immun. 57: 3720-3726 (1989).
  3. Lee, K.K., P.A. Sastry, W. Paranchych and R.S. Hodges. Immunological studies of the disulfide region of Pseudomonas aeruginosa  PAK and PAO pilins, using anti-PAK pilus and antipeptide antibodies. Infect. Immun. 57: 520-526 (1989).
  4. Carayanniotis, G., E. Vizi, J.M.R. Parker, R.S. Hodges and B.H. Barber. Delivery of synthetic peptides by anti-class II MHC monoclonal antibodies induces specific adjuvant-free IgG responses elicited in vivo . Mol. Immunology  25: 907-911 (1988)
  5. Hodges, R.S., R.J. Heaton, J.M.R. Parker, L. Molday and R.S. Molday.  Antigen-antibody interaction: Synthetic peptides detect linear antigenic determinants for anti-rhodopsin  monoclonal antibodies. J. Biol. Chem. 263: 11768-11775 (1988).
  6. Strynadka, N.C.J., M.J. Redmond, J.M.R. Parker, D.G. Scraba and R.S. Hodges.  The use of synthetic peptides to map the antigenic determinants of glycoprotein D of Herpes Simplex Virus.  J. Virology  62: 3474-3483 (1988).
  7. Doig, P., T. Todd, P.A. Sastry, K.K. Lee, R.S. Hodges, W. Paranchych and R.T. Irvin. The role of pili in the adhesion of Pseudomonas aeruginosa to human respiratory epithelial cells. Infect. Immun. 56: 1641-1646 (1988).
  8. Zubrzycka-Gaarn, E.E., D.E. Bulman, G. Karpati, A.H.M. Burghes, B. Belfall, H.J. Klamut,  J.A. Talbot, R.S. Hodges, P.N. Ray and R.G. Worton. The Duchenne muscular dystrophy gene product is localized in the sarcolemma of human skeletal muscle fibers. Nature (London)  333: 466-469 (1988).
  9. Naquet, P., J. Ellis, D. Tibensky, A. Kenshole, B. Singh, R.S. Hodges and T.L. Delovitch.  T cell autoreactivity to insulin in diabetic and related non-diabetic individuals. J. Immunol. 140: 2569-2578 (1988).
  10. Naquet, P., J. Ellis, B. Singh, R.S. Hodges and T.L. Delovitch. Processing and presentation of insulin. I. Analysis of immunogenic peptides and processing requirements for insulin A loop-specific T-cells. J. Immun. 139: 3955-3963 (1987).
  11. Naquet, P., M.L. Phillips, J. Ellis, R. Hodges, B. Singh and T.L. Delovitch. Structural requirements for T cell antigenic sites on insulin.  In "Immunogenicity of Protein Antigens:  Repertoire and Regulation" Volume I (E. Sercarz and J. Berzofsky, Eds.) CRC Uniscience Series, CRC Press (1987), pp. 49-56.
  12. Naquet, P., J. Ellis, D. Tibensky, A. Kenshole, B. Singh, R.S. Hodges and T.L. Delovitch. Immune response to insulin in Type I diabetes.  In "The Immunology of Diabetes Mellitus" (M.A. Jaworski, G.D. Molnar, R.V. Rajotte and B. Singh, Eds.), Excerpta Medica, Amsterdam (1986) pp. 231-239.
  13. Hodges, R.S., J.M.R. Parker and B. Singh. Synthetic antigens in immunology.  Immunology in  Canada, Supplement to: Immunology Today pp. 16-17, Elsevier Science Publishers B.V. (1986).
  14. Worobec, E.A., L.S. Frost, P. Pieroni, G.D. Armstrong, R.S. Hodges, J.M.R. Parker, B.B. Finlay and W. Paranchych. The location of the antigenic determinants of conjugative F-like pili J. Bact. 167: 660-665 (1986).
  15. Smith, M.H., J.M.R. Parker, R.S. Hodges and B.H. Barber. The preparation and  characterization of heteroantisera recognizing subregions of the intracytoplasmic domain of class I H-2 antigens123. Molecular Immunology  23: 1077-1092 (1986).
  16. Finlay, B.B., L.S. Frost, W. Paranchych, J.M.R. Parker and R.S. Hodges. The major antigenic determinants of F and Col B2 pili. J. Bact. 163: 331-335 (1985).
  17. Parker, J.M.R. and R.S. Hodges. II. Photoaffinity probes provide a general method to prepare peptide conjugates from native protein fragments. J. Protein Chem. 3: 479-489 (1985).
  18. Worobec, E.A., W. Paranchych, J.M.R. Parker, A.K. Taneja and R.S. Hodges. Antigen-antibody interaction: The immunodominant region of EDP208 pili. J. Biol. Chem. 260:938-943 (1985).
  19. Parker, J.M.R. and R.S. Hodges. I. Photoaffinity probes provide a general method to prepare synthetic peptide-conjugates. J. Protein Chem. 3: 465-478 (1985).

1980-1984
  1. Leung, W.-C., A. Ramsingh, G. Jing, K. Mong, A.K. Taneja and R.S. Hodges. Sub-genomic RNA of Arenavirus pichinde and its implication in regulation of viral gene expression in productive infection and persistence. In "Segmented Negative Strand Viruses" (ed. R. Compans and D. Bishop), Academic Press, pp. 109-116 (1984).
  2. Hodges, R.S., J.M.R. Parker, A.K. Taneja, E.A. Worobec and W. Paranchych. Immuno-dominant region of EDP208 pili: Antigen-antibody interaction. In  "Modern Approaches to Vaccines: Molecular and Chemical Basis of Virus Virulence and Immunogenicity" (R.M. Chanock and R.A. Lerner, eds.) Cold Spring Harbor Laboratory Press, pp. 415-420 (1984).
  3. Parker, J.M.R., S. Bhargava and R.S. Hodges. A general method to prepare synthetic peptide-conjugates. In  "Modern Approaches to Vaccines: Molecular and Chemical Basis of Virus Virulence and Immunogenicity" (R.M. Chanock and R.A. Lerner, eds.) Cold Spring Harbor Laboratory Press, pp. 133-138 (1984).
  4. Watts, T.H., P.A. Sastry, R.S. Hodges and W. Paranchych. Mapping of the antigenic determinants of Pseudomonas aeruginosa PAK polar pili. Infect. Imm. 42: 113-121 (1983).
  5. Worobec, E.A., A.K. Taneja, R.S. Hodges and W. Paranchych. Localization of the major antigenic determinant of EDP 208 pili at the N-terminus of the pilus protein.  J. Bacteriol. 153: 955-961 (1983).​

Proceedings Publications

2015-2019
  1. Jiang, Z., L. Gera, C.T. Mant and R.S. Hodges. Antibody cross-reactivity to hemagglutinin protein antigens demonstrates feasibility for development of a “Universal” Influenza A synthetic peptide vaccine. In Enabling Peptide Research from Basic Research to Drug Discovery, Proceedings of the 24th American Peptide Symposium, Orlando, FL (V. Srivastava, A. Yudin and M. Lebl, editors) pp. 36-39 (2015). Published by the American Peptide Society and Propt Scientific Publishing, 2015.

2010-2014
  1. Jiang, Z., L. Gera, W. Hartsock, Z. Yan, B. Hirsch, C.T. Mant, Z. Qian, K.V. Holmes, J.P. Kirwan and R.S. Hodges. Platform technology to develop synthetic peptide vaccines to prevent viral infections. In Peptides Across the Pacific, Proceedings of the 23rd American Peptide Symposium, Big Island of Hawaii, USA (M. Lebl, Ed.) pp. 132-133 (2013) Published by the American Peptide Society, 2013.
  2. Hartsock, W.J., Z. Yan and R.S. Hodges. Solid-phase synthesis of a branched peptide to form a homo-two-stranded coiled-coil for the development of a universal flu vaccine. In Peptides: Building Bridges (M. Lebl, Ed.), Proceedings of the 22nd American Peptide Symposium, San Diego, CA, pp. 142-143 (2011).
  3. Hackbarth, C.L. and R.S. Hodges. Antigenic determinants of cross-reactivity in the development of a Pseudomonas aeruginosa peptide vaccine targeting the receptor binding domain of the Type IV pilus. In Peptides: Building Bridges (M. Lebl, Ed.), Proceedings of the 22nd Amercan Peptide Symposium,San Diego, CA, pp. 146-147 (2011).

2005-2009
  1. Yan, Z., K.V. Holmes and R.S. Hodges. Expression and Characterization of Recombinant S2 Subunit of SARS-coronavirus S Fusion Protein.  In Peptides for Youth, Proceedings of the 20th American Peptide Symposium, Montreal, Quebec, Canada (2007). (S. Del Valle, E. Escher, W.D. Lubell, (Eds) Springer p. 153-154 (2009) and Adv. Exp. Med. Biol. 611: 153-154 (2009).
  2. Kao, D. and R.S. Hodges.  Development of a Monoclonal Antibody Therapeutic for the Prevention and Treatment of Pseudomonas aeruginosa Infection.  In Understanding Biology Using Peptides:  Proceedings of the 19th American Peptide Symposium.  San Diego, CA (2005) (S.E. Blondelle, Ed.)  Springer Science, New York, NY  pp 531-532 (2006).
  3. Yan, Z., B. Tripet and R.S. Hodges.  Design and Study of Novel Peptide Inhibitors against SARS-Coronavirus Spike Protein.  In Understanding Biology Using Peptides:  Proceedings of the 19th American Peptide Symposium.  San Diego, CA (2005) (S.E. Blondelle, Ed.)  Springer Science, New York, NY  pp 335-337 (2006).

2000-2004
  1. Chen, Y., L.H. Kondejewski, C.M. Kay, R.T. Irvin and R.S. Hodges. Design and synthesis of prion peptidyl mimetics for the detection and purification of prion proteins. In Peptides for the New Millennium”, Proceedings of the Sixteenth American Peptide Symposium (G.B. Fields, J.P. Tam and G. Barany, Eds.), Kluwer Academic Publishers, pp. 713-714 (2000).

1995-1999
  1. Yang, C.M.C., W.Y. Wong, O. Hindsgual, R.T. Irvin and R.S. Hodges.  Multivalent carbohydrate-linked peptides interfere with adherence of Candida albicans to asialo-GM1 receptor:  Toward the design of anti-adhesin therapeutics.  In Peptides:  Frontiers of Peptide Science, Proceedings of the Fifteenth American Peptide Symposium (J. Tam and P. Kaumaya, Eds.) Kluwer Academic Publishers, pp. 557-558 (1999).
  2. Wade, D., P. Semchuk and R.S. Hodges.  Synthetic Peptide Vaccine for Pseudomonas Aeruginosa.  In:   Peptides:  Chemistry, Structure and Biology, Proceedings of the Fourteenth American Peptide Symposium (P. Kaumaya and R.S. Hodges, Eds.) Mayflower Scientific Ltd., England, pp. 796-797 (1996).
  3. Wong, W.Y., W. Paranchych, R.S. Hodges, R.T. Irvin.  Mapping the adhesintope of the Pilin proteins of Pseudomonas aeruginosa strains PAK and KB7.  Peptides:  Chemistry, Structure and Biology, Proceedings of the Fourteenth American Peptide Symposium (P. Kaumaya and R.S. Hodges, Eds.) Mayflower Scientific Ltd., England, pp. 352-353 (1996).

1990-1994
  1. McInnes, C., C.M. Kay, R.S. Hodges and B.D. Sykes.  Conformational differences between the cis and trans proline isomers of a synthetic antigen from the pilus of Pseudomonas aeruginosa.  In:  Peptides:  Chemistry, Structure and Biology, Proceedings of the Thirteenth American Peptide Symposium (R.S. Hodges and J.A. Smith, Eds.), Escom Science Publishers, Leiden, The Netherlands, pp.748-749 (1994).
  2. Lee, K.K., H.B. Sheth, R.T. Irvin, R.S. Hodges, W. Paranchych and O. Hindsgaul.  Peptide-carbohydrate interactions:  Understanding bacterial adherence to host cell receptors.  In:  Peptides:  Chemistry, Structure and Biology, Proceedings of the Thirteenth American Peptide Symposium (R.S. Hodges and J.A. Smith, Eds.), Escom Science Publishers, Leiden, The Netherlands, pp.672-674 (1994).
  3. Wong, W.Y., H.B. Sheth, A. Holm, R.T. Irvin and R.S. Hodges.  Investigation of antibody binding diversity utilizing representative combinatorial peptide libraries.  In:   Peptides:  Chemistry, Structure and Biology, Proceedings of the Thirteenth American Peptide Symposium (R.S. Hodges and J.A. Smith, Eds.), Escom Science Publishers, Leiden, The Netherlands, pp.995-997 (1994).​
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2015-2019
  1. Jiang, Z., L. Gera, C.T. Mant and R.S. Hodges. Design of new antimicrobial peptides (AMPs) with “specificity determinants” that encode selectivity for gram-negative pathogens and remove gram-positive and hemolytic activity from broad-spectrum AMPs. In Enabling Peptide Research from Basic Research to Drug Discovery, Proceedings of the 24th American Peptide Symposium, Orlando, FL (V. Srivastava, A. Yudin and M. Lebl, editors) pp. 245-248 (2015). Published by the American Peptide Society and Propt Scientific Publishing, 2015.

2010-2014
  1. Jiang, Z., A.I. Vasil, M.L. Vasil and R.S. Hodges. “Specificity determinants” improve therapeutic indices of two antimicrobial peptides Piscidin 1 and Dermaseptin S4 against gram-negative pathogens Acinetobacter baumannii and Pseudomonas aeruginosa. Pharmaceuticals 7: 366-391 (2014); DOI 10.3390/ph7040366.
  2. Z. Jiang, A.I. Vasil, L. Gera, M.L. Vasil and R.S. Hodges.  Rational design of a-helical antimicrobial peptides to target gram-negative pathogens, Acinetobacter baumannii and Pseudomonas aeruginosa:  Utilization charge, “specificity determinants”, total hydrophobicity, hydrophobe type and location as design parameters to improve the  therapeutic ratio. Chem. Biol & Drug Design 77: 225-240 (2011). (Journal Cover Figure)
  3. Hodges, R.S., Z. Jiang, J. Whitehurst, and C.T. Mant.  Devleopment of antimicrobial peptides as therapeutic agents.  In, “Development of Therapeutic Agents Handbook” First Edition, edited by Shayne C. Gad), John Wiley and Sons Inc. pp. xx-xx (in press, 2011).
  4. Hartsock, W. and R.S. Hodges. Rational design of amphipathic α-helical and cyclic β-sheet antimicrobial peptides: specificity and therapeutic potential. In, “Peptide Drug Discovery and Development. Translational Research in Academia and Industry.” First Edition Castanho, M. and Santos N. (Eds.) Wiley Publishers. pp. 91-117 (2011).
  5. Jiang, Z., A.I. Vasil, L. Gera, M.L. Vasil and R.S. Hodges.  Specificity determinants dramatically reduce hemolytic activity in amphipathic α-helical antimicrobial peptides: antimicrobial activity against Gram-negative pathogens, Acinetobacter baumannii and Pseudomonas aeruginosa. Proceedings of the 2010 International Conference on Antimicrobial Research, In “Science and Technology against Microbial Pathogens. Research, Development and Evaluation” World Scientific Publishing Co., Pte. Ltd. pp. 376-380 (2011).
  6. Baumgartner, H.K., N. Beeman, R.S. Hodges and M.C. Neville.  A D-peptide analog of the second extracellular loop of claudin-3 and -4 leads to mis-localized claudin and cellular apoptosis in mammary epithelial cells.  Chem. Biol. & Drug Design 77: 124-136 (2011). (Journal Cover Figure)
  7. Jiang, Z., M.P. Higgins, J. Whitehurst, K.O. Kisich, M.I. Voskuil and R.S. Hodges.  Anti-tuberculosis activity of a-helical antimicrobial peptides: de novo designed L- and D-enantiomers versus L- and D-LL37. Protein and Peptide Letters 18: 241-252 (2011).
  8. Gambin, Y., M. Reffay, E. Sierecki, F. Homblé, R.S. Hodges, N.S. Gov, N. Taulier and W. Urbach.  Variation in the lateral mobility of transmembrane peptides with hydrophobic mismatch.  J. Phys. Chem. B. 114: 3559-3566 (2010).

2005-2009
  1. Reffray, M., Gambin, Y., Benabdelhak, H., Phan, G., Taulier, N., Ducruix, A., Hodges, R.S. and Urbach, W.  Tracking membrane protein association in model membranes.  Public library of Science 4: 1-9 (2009) (e5035) www.plosone.org..
  2. Jelokhani-Niaraki, M., L.H. Kondejewski, L. Wheaton and R.S. Hodges.  Effect of ring-size on conformation and biological activity of cyclic cationic antimicrobial peptides.  Journal of Medicinal Chemistry 52: 2090-2097 (2009).
  3. Jiang, Z., B.J. Kullberg, H. vander Lee, A.I. Vasil, J.D. Hale, C.T. Mant, R.E.W. Hancock, M.L. Vasil, M.G. Netea and R.S. Hodges.  Effects of hydrophobicity on the anti-fungal activity of a-helical antimicrobial peptides.  Chemical Biology and Drug Design 72: 483-495 (2008).
  4. Jelokhani-Niaraki, M., R.S. Hodges, J. E. Meissner, U. E. Hassenstein and L. Wheaton.  Interaction of Gramicidin S and its aromatic amino acid analogues with phospholipid membranes.  Biophysical Journal 95: 3306-3321 (2008).
  5. Simon, A., B.J. Kullberg, B. Tripet, O.C. Boerman,  P. Zeeuwen, J. vander Ven-Jongkrijg, P. Verweij, J. Schalkwijk, R.S. Hodges, J.W.M. vander Meer, M.G. Netea.  Drosomycin-like Defensin (DLD):  a human homologue of Drosophila melanogaster drosomycin with antifungal activity.  Antimicrobial Agents and Chemotherapy 52: 1407-1412 (2008).
  6. Jiang, Z., A.I. Vasil, J. Hale, R.E.W. Hancock, M.L. Vasil and R.S. Hodges.  Effects of net charge and the number of positively charged residues on the biological activity of amphipathic a-helical cationic antimicrobial peptides.  Biopolymers (Peptide Science) 90:  369-383 (2008).
  7. Abraham, T., S. Marwaha, D.M. Kobewka, R.N. Lewis, E.J. Prenner, R.S. Hodges, and R.N. McElhaney.  The relationship between the binding to and permeabilization of phospholipid bilayer membranes by GS14dK4, a designed analog of the antimicrobial peptide gramicidin S.  Biochimica et Biophysica Acta – Biomembranes 1768: 2089-2098 (2007).
  8. Lewis, R.N.A.H., F. Liu, R. Krivanek, R. Rybar, T. Hianik, C.R. Flach, R. Mendelsohn, Y. Chen, C.T. Mant, R.S. Hodges and R.N. McElhaney.  Studies of the Minimum Hydrophobility of a-Helical Peptides Required to Maintain a Stable Transmembrane Association with Phospholipid Bilayer Membranes.  Biochemistry 46: 1042-1054 (2007).
  9. Chen, Y., M.T. Guarnieri, A.I. Vasil, M.L. Vasil, C.T. Mant and R.S. Hodges. The Role of Peptide Hydrophobicity in the Mechanism of Action of a-Helical Antimicrobial Peptides Antimicrob. Agents Chemothera.  51: 1398-1406 (2007).
  10. Gambin, Y., R. Lopez-Esparza, M. Reffay, E. Sierecki, N.S. Gov, M. Genest, R.S. Hodges, and W. Urbach. Lateral Mobility of Proteins in Liquid Membranes Revisited.  PNAS 103: 2098-2102 (2006).
  11. Chen, Y., A.I. Vasil, L. Rehaume, C.T. Mant, J.L. Burns, M.L. Vasil, R.E.W. Hancock, R.S. Hodges. Comparison of biophysical and biological properties of a-helical enantiomeric antimicrobial peptides. Chemical Biology and Drug Design 67: 162-173 (2006).
  12. Abraham, T., Ruthven N. A. H. Lewis, R.S. Hodges and R.N. McElhaney, Isothermal Titration Calorimetry Studies of the Binding of the Antimicrobial Peptide Gramicidin S to Phospholipid Bilayer Membranes, Biochemistry 44: 11279-11285 (2005).
  13. Abraham, T., R.N.A.H. Lewis, R.S. Hodges and R.N. McElhaney.  Isothermal titration calorimetry studies of the binding of a rationally designed analogue of the antimicrobial peptide Gramicidin S to phospholipid bilayer membrances.  Biochemistry 44: 2103-2112 (2005).
  14. Chen, Y., C.T. Mant, S.W. Farmer, R.E.W. Hancock, M.L. Vasil and R.S. Hodges.  Rational design of a-helical antimicrobial peptides with enhanced activities and specificity/therapeutic index.  J. Biol. Chem. 280: 12316-12329 (2005).
  15. Prenner, E.J., M. Kiricsi, M. Jelokhani-Niaraki, R.N.A.H. Lewis, R.S. Hodges and R.N. McElhaney.  Structure-activity relationships of diastereomeric lysine ring size analogs of the antimicrobial peptide Gramicidin S:  mechanism of action and discrimination between bacterial and animal cell membranes.  J. Biol. Chem. 280: 2002-2011 (2005).

2000-2004
  1. Liu, F., R.N.A.H. Lewis, R.S. Hodges and R.N. McElhaney.  Effect of variations in the structure of a polyleucine-based a-helical transmembrane peptide on its interaction with phosphatidylethanolamine bilayers.  Biophysical Journal 87: 2470-2482 (2004).
  2. Houliston, R.S., R.S. Hodges, F.J. Sharom and J.H. Davis.  Characterization of the proto-oncogenic and mutant forms of the transmembrane region of Neu in micelles.  J. Biol. Chem 279: 24073-24080 (2004).  Also in Proteomics Select, Vol. 3, Issue 12 (2004)
  3. Lee, D.L., J.-P.S Powers, K. Pflegerl, M.L. Vasil, R.E.W. Hancock, and R.S. Hodges. Effects of single D-amino acid substitutions on disruption of b-sheet structure and hydro­phobicity in cyclic 14-residue antimicrobial peptide analogs related to gramicidin S. J. Peptide Research 63: 69-84 (2004).
  4. Liu, F., R.N.A.H. Lewis, R.S. Hodges and R.N. McElhaney.  Effect of variations in the structure of a polyleucine-based a-helical transmembrane peptide on its interaction with phosphatidylglycerol bilayers.  Biochemistry 43: 3679-3687 (2004).
  5. Houliston, R. S., R. S. Hodges, F. J. Sharom and J. H. Davis. Comparison of proto-oncogenic and mutant forms of the transmembrane region of the Neu receptor in TFE.  FEBS Letters 535: 39-43 (2003).
  6. Lewis, R.N.A.H., M. Kiricsi, E.J. Prenner, R.S. Hodges and R.N. McElhaney. Fourier transform infrared spectroscopic study of the interactions of a strongly antimicrobial but weakly hemolytic analog of gramicidin S with lipid micelles and lipid bilayer membranes. Biochemistry 42: 440-449 (2003).
  7. Kondejewski, L.H. and R.S. Hodges. Design, synthesis and characterization of cyclic b-sheet peptides. In: Synthesis of Peptides and Peptidomimetics. Houben-Weyl Methods of Organic Chemistry (M. Goodman, A. Felix, L. Moroder and C. Toniolo, Eds.) Thieme Stuttgart, Vol. E22d: 114-128 (2003).
  8. Lee, D.L. and R.S. Hodges. Structure-activity relationships of de novo designed cyclic antimicrobial peptides based on gramicidin S. Peptide Science (Biopolymers71: 28-48 (2003).
  9. Kiricsi, M., E.J. Prenner, M. Jelokhani-Niaraki, R.N.A.H. Lewis, R.S. Hodges and R.N. McElhaney. The effects of ring-size analogs of the antimicrobial peptide gramicidin S on phospholipid bilayer model membranes and on the growth of Acholeplasma laidlawii BEur. J. Biochemistry 269: 5911-5920 (2002).
  10. Liu, F., R.N.A.H. Lewis, R.S. Hodges and R.N. McElhaney. Effect of variations in the structure of a polyleucine-based a-helical transmembrane peptide on its interaction with phosphatidylcholine bilayers. Biochemistry 41: 9197-9207 (2002).
  11. Jelokhani-Niaraki, M., E.J. Prenner, C.M. Kay, R.N. McElhaney and R.S. Hodges. Conformation and interaction of the cyclic cationic antimicrobial peptides in lipid bilayers.  J. Peptide Res. 60: 23-36 (2002).
  12. Gibbs, A.C., T.C. Bjorndahl, R.S. Hodges and D.S. Wishart.  Probing the structural determinants of Type II¢ b-turn formation in peptides and proteins.  JACS 124: 1203-1213 (2002).
  13. Kondejewski, L.H., D.L. Lee, M. Jelokhani-Niaraki, S.W. Farmer, R.E.W. Hancock and R.S. Hodges.  Optimization of microbial specificity in cyclic peptides by modulation of hydrophobicity within a defined structural framework. J. Biol. Chem. 277: 67-74 (2002).
  14. Zhang, Y.P., R.N. Lewis, R.S. Hodges and R.N. McElhaney. Peptide models of the helical hydrophobic transmembrane segments of membrane proteins: Interactions of acetyl-K2-(LA)12-K2-amide with phosphatidylethanolamine bilayer membranes. Biochemistry 40: 474-482 (2001).
  15. Tsapis, N., F. Reiss-Husson, R. Ober, M. Genest, R.S. Hodges and W. Urbach. Self diffusion and spectral modifications of a membrane protein, the Rubrivivax gelatinosus LH2 complex, incorporated into a monoolein cubic phase. Biophysical Journal 81: 1613-1623 (2001).
  16. Salgado, J., S.L. Grage, L.H. Kondejewski, R.S. Hodges, R.N. McElhaney and A.S. Ulrich. Membrane-bound structure and alignment of the antimicrobial b-sheet peptide gramicidin S derived from angular and distance constraints by solid-state 19F-NMR. J. Biomol. NMR 21: 191-208 (2001).
  17. Lewis, R.N.A.H., Y.-P. Zhang, R.S. Hodges, W.K. Subczynski, A. Kusimi, C.R. Flach, R. Mendelsohn and R.N. McElhaney. A polyalanine-based peptide can not form a stabletransmembrane a-helix in fully hydrated phospholipid bilayers. Biochemistry 40: 12103-12111 (2001).
  18. Jelokhani-Niaraki, M., E.J. Prenner, L.H. Kondejewski, C.M. Kay, R.N. McElhaney, and R.S. Hodges. Conformation and other biophysical properties of cyclic antimicrobial peptides in aqueous solutions.  J. Peptide Res. 58: 293-306 (2001).
  19. Prenner, E.J., R.N.A.H. Lewis, M. Jelokhani-Niaraki, R.S. Hodges, and R.N. McElhaney.  Cholesterol attenuates the interaction of antimicrobial peptide gramicidin S with phospholipid bilayer membranes.  BBA Biomembranes 1510: 83-92 (2001).
  20. Liu, F., R.N.A.H. Lewis, R.S. Hodges and R.N. McElhaney. A differential scanning calorimetric and 31P NMR spectroscopic study of the effect of transmembrane a-helical peptides on the lamellar-reversed hexagonal phase transition of phosphatidyl­ethanol­amine model membranes. Biochemistry 40:  760-768 (2001).
  21. Jelokhani-Niaraki, M., L.H. Kondejewski, S.W. Farmer, R.E.W. Hancock, C.M. Kay and R.S. Hodges.  Diasteriomeric Analogs of Gramicidin S:  Structure, Biological Activity and Interaction with Lipid Bilayers.  Biochem. J. 349: 747-755 (2000).
  22. McInnes, C., L.H. Kondejewski, R.S. Hodges, B.D. Sykes.  Development of the Structural Basis for Antimicrobial Activities of Peptides Based on Gramicidin S and Design of Novel Analogs Using NMR Spectroscopy.  J. Biol. Chem. 275:  14287-14294 (2000).
  23. Taulier, N., C. Nicot, M. Waks, R.S. Hodges, R. Ober and W. Urbach.  Unbinding-binding transition induced by molecular snaps in model membranes.  Biophysical J. 78:  857-865 (2000).

1995-1999
  1. Langlais, D.B., R.S. Hodges and J.H. Davis.  13C-13C rotational resonance in a trans-membrane peptide:  A comparison of the fluid and gel phases.  Physical Review E 59: 5945-5957 (1999).
  2. Lewis, R.N.A.H., E.J. Prenner, L.H. Kondejewski, C.R. Flach, R. Mendelson, R.S. Hodges and R.N. McElhaney.  Fourier transform infrared spectroscopic studies on the interaction of the antimicrobial peptide gramicidin S with lipid micelles and with lipid monolayer and bilayer membranes.  Biochemistry 38: 15193-15203  (1999).
  3. Kondejewski, L.H., M. Jelokhani-Niaraki, S.W. Farmer, C.M. Kay, B.D. Sykes, R.E.W. Hancock and R.S. Hodges.  Dissociation of antimicrobial and hemolytic activities in cyclic peptide diastereomers by systematic alterations in amphipathicity.  J. Biol. Chem. 274:  13181-13192 (1999).
  4. Prenner, E.J., R.N.A.H. Lewis, L.H. Kondejewski, R.S. Hodges and R.N. McElhaney.  Differential scanning calorimetric study of the effect of the antimicrobial peptide gramicidin S on the thermotropic phase behavior of phosphatidylcholine, phosphotidylethanolamine and phosphatidyl glycerol lipid bilayer membranes.  Biochem. Biophys. Acta 1417:  211-223 (1999).
  5. Gibbs, A.C., L.H. Kondejewski, W. Gronwald, A.M. Nip, R.S. Hodges, B.D. Sykes and D.S. Wishart.  Unusual b-sheet periodicity in small cyclic peptides.  Nature Structural Biol. 5:  284-288 (1998).
  6. Subczynski, W.K., R.N.A.H. Lewis, R.N. McElhaney, R.S. Hodges, J.A. Hyde and A. Kusumi.  Molecular organization and dynamics of 1-palmitoyl-2-oleoylphosphatidyl choline bilayers containing a transmembrane a-helical peptide.  Biochem. 37:  3156-3164 (1998).
  7. Houston, M.E., L.H. Kondejewski, D.N. Karunaratue, M. Gough, S. Fidai, R.S. Hodges and R.E.W. Hancock.  Influence of preformed a-helix and a-helix induction on the activity of cationic antimicrobial peptides.  J. Peptide Research 52:  81-88 (1998).
  8. Prenner, E.J., R.N.A.H. Lewis, K.C. Neuman, S.M. Gruner, L.H. Kondejewski, R.S. Hodges and R.N. McElhaney.  Nonlamellar phases induced by the interaction of Gramicidin S with lipid bilayers.  A possible relationship to membrane-disrupting activity.  Biochemistry 36:  7906-7916 (1997).
  9. Kondejewski, L.H., S.W. Farmer, D.S. Wishart, C.M. Kay, R.E.W. Hancock and R.S. Hodges.  Modulation of structure and antibacterial and hemolytic activity by ring size in cyclic Gramicidin S analogs.  J. Biol. Chem. 271:  25261-25268 (1996).
  10. Wishart, D.S., L.H. Kondejewski, P.D. Semchuk, B.D. Sykes and R.S. Hodges.  A method for the facile solid-phase synthesis of gramicidin S and its analogs.  Lett. Pept. Sci. 3:  53-60 (1996).
  11. Kondejewski, L.H., S.W. Farmer, D.S. Wishart, R.E.W. Hancock and R.S. Hodges.  Gramicidin S is active against gram negative bacteria.  Int. Journal Peptide Protein Res. 47:  460-466 (1996).
  12. Davis, J.H., M. Auger and R.S. Hodges.  High Resolution 'H NMR of a trans-membrane peptide.  Biophysical Journal 69:  1917-1932 (1995).
  13. Zhang, Y.P., R.N.A.H. Lewis, R.S. Hodges and R.N. McElhaney.  Peptide models of helical hydrophobic transmembrane segments of membrane proteins II.  Differential scanning calorimetric and FTIR spectroscopic studies of the interaction of Ac-K2(LA)12K2-amide with phosphatidylcholine bilayers.  Biochemistry 34:  2362-2371 (1995).
  14. Y.P. Zhang, R.N.A.H. Lewis, G.D. Henry, B.D. Sykes, R.S. Hodges and R.N. McElhaney.  Peptide models of helical hydrophobic transmembrane segments of membrane proteins. 1. Studies of the conformation, intrabilayer orientation and amide hydrogen exchangeability of Ac-K2-(LA)12-K2-Amide.  Biochemistry 34:  2348-2361 (1995).
  15. Zhang, Y.-P., R.N.A.H. Lewis, R.S. Hodges and R.N. McElhaney.  Interaction of a peptide model of a hydrophobic transmembrane a-helical segment of a membrane protein with phosphatidylethanolamine bilayers: Differential scanning calorimetric and FTIR spectroscopic studies.  Biophysical Journal  68: 847-857 (1995).
  16. Wishart, D.S., L.H. Kondejewski, P.D. Semchuk, C.M. Kay, R.S. Hodges and B.D. Sykes.  Design, synthesis and characterization of a water-soluble β-sheet peptide.  In:  "Techniques in Protein Chemistry VI", (J.W. Crabb, Ed.).  Academic Press Inc. pp. 451-466 (1995).

1990-1994
  1. Zhang, Y.-P., R.N.A.H. Lewis, R.S. Hodges and R.N. McElhaney.  Interaction of a peptide model of a hydrophobic transmembrane a-helical segment of a membrane protein with phosphatidylcholine bilayers:  Differential scanning calorimetric and FTIR spectroscopic studies.  Biochemistry 31: 11579-11588 (1992).
  2. Zhang, Y.-P., R.N.A.H. Lewis, R.S. Hodges and R.N. McElhaney.  FTIR spectroscopic studies of the conformation and amide hydrogen exchange of a peptide model of the hydrophobic transmembrane a-helices of membrane proteins.  Biochemistry 31:  11572-11578 (1992).

1985-1989
  1. Roux, M., J.-M. Neuman, R.S. Hodges, P.F. Devaux and M. Bloom.  Conformational changes of phospholipid head groups induced by a cationic integral membrane peptide as seen by deuterium magnetic resonance.  Biochemistry  28: 2313-2321 (1989).
  2. Pauls, K.P., A.L. MacKay, O. Soderman, M. Bloom, A.K. Taneja and R.S. Hodges.  Dynamic properties of the backbone on an integral membrane polypeptide as measured by 2H-NMR. Eur. Biophys. J. 12: 1-11 (1985).
  3. Huschilt, J.C., R.S. Hodges and J.H. Davis. Phase equilibria in an amphiphilic peptide-phospholipid model membrane by 2H-nuclear magnetic resonance  difference spectroscopy. Biochemistry  24:1377-1386 (1985).

1980-1984
  1. Davis, J.H., D.M. Clare, R.S. Hodges and M. Bloom.  The interaction of a synthetic amphiphilic polypeptide and lipids in a bilayer structure. Biochemistry  22:  5298-5305 (1983).
  2. Davis, J.H., R.S. Hodges and M. Bloom. The interaction between a synthetic amphiphilic polypeptide and lipids.  Biophys. J.  37: 170-171 (1982).​
​​
Proceedings Publications

2015-2019
  1. Hodges, R.S. and Z. Jiang. Design of new antimicrobial peptides (AMPs): “Specificity Determinants” erode gram-negative pathogen selectivity and remove both gram-positive activity and hemolytic activity from broad-spectrum AMPs. First International Caparica Conference in Antibiotic Resistance, Caparica, Portugal 2015. IC2AR2015 Proceedings (C. Lodeiro, J.L. Capelo, H.M. Santos, E. Oliveira, C. Nunez-Glez, J.E. Araujo and A.F. Lodeiro, editors) p. 84 (2015) (www.IC2AR.com).

2010-2014
  1. Abraham, T., E.J. Prenner, R.N.A.H. Lewis, C.T. Mant, S. Keller, R.S. Hodges and R.N. McElhaney. Structure-activity relationships of the antimicrobial peptide gramicidin S and its analogs: Aqueous solubility, self-association, conformation, antimicrobial activity and interaction with model lipid membranes. Biochim. Biophys. Acta 1838: 1420-1429 (2014). No PMC or PMID
  2. Hackbarth, C.L. and R.S. Hodges. Antigenic determinants of cross-reactivity in the development of a Pseudomonas aeruginosa peptide vaccine targeting the receptor binding domain of the Type IV pilus. In Peptides: Building Bridges (M. Lebl, Ed.), Proceedings of the 22nd Amercan Peptide Symposium,San Diego, CA, pp. 146-147 (2011).
  3. Hartsock, W.J., Z. Jiang, L. Gera, C.T. Mant, D.I. Vasil, M. Vasil and R.S. Hodges.  Evaluation an α-helical antimicrobial peptide targeting gram-negative pathogens in a systemic animal model.  In Peptides: Building Bridges (M. Lebl, Ed.), Proceedings of the 22nd American Peptide Symposium, San Diego, CA, pp. 144-145 (2011).
  4. Jiang, Z., A.I. Vasil, M.L. Vasil, and R.S. Hodges. Effect of net positive charge and charge distribution on the polar face of amphipathic a-helical antimicrobial peptides on their biological and biophysical properties.  In Breaking Away: Proccedings of the 21st American Peptide Symposium. Bloomington, IN, (2009), M. Lebl (Ed.), American Peptide Society 266-267 (2010).

2005-2009
  1. Jiang, Z., A.I. Vasil, J. Hale, R.E.W. Hancock, M.L. Vasil and R.S. Hodges.  Effects of net charge and number of positively charged residues on the biological activity of amphipathic a-helical cationic antimicrobial peptides.  In Peptides for Youth, Proceedings of the 20th American Peptide Symposium, Montreal, Quebec, Canada (2007). (S. Del Valle, E. Escher, W.D. Lubell, (Eds) Springer p. 561-562 (2009) and Adv. Exp. Med. Biol. 611: 561-562 (2009).
  2. Chen, Y., M. Guarnieri, M. Vasil and R.S. Hodges.  Rational Design of a-Helical Antimicrobial Peptides.  In Understanding Biology Using Peptides:  Proceedings of the 19th American Peptide Symposium.  San Diego, CA (2005) (S.E. Blondelle, Ed.)  Springer Science, New York, NY  pp 291-292 (2006).
  3. Chen, Y. and R.S. Hodges.  Rational design of a-helical antimicrobial peptides with improved specificity.  In “Peptides, Biology and Chemistry; Proceedings of the 2004 Chinese Peptide Symposium, Kunming, China,” Ke-Llang Liu and James Tam, Eds. Science Press USA 2005 pp. 46-48.
  4. Jelokhani-Niaraki, M., E.J. Prenner and R. S. Hodges.  Biophysical Studies of Cyclic Cationic Antimicrobial Peptides.  “Proceedings of the 1st Asia-Pacific International Peptide Symposium (APIPS), Fukuoka, Japan Oct 31-Nov 3, 2004” In Peptide Science 2004 (Y. Shimohigashi, Ed.) Japanese Peptide Society, pp. 75-78 (2005).

2000-2004
  1. Jelokhani-Niaraki, M., L.H. Kondejewski, C.M. Kay and R.S. Hodges. Variation in ring size of cyclic antimicrobial peptides results in diversity and selectivity of biological activity. In “Peptides: The Wave of the Future”, Proceedings of the Second International/Seventeenth American Peptide Symposium (M. Lebl and R.A. Houghten, Eds.), Kluwer Academic Publishers, pp. 497-498 (2001).
  2. Lee, D.L., S.W. Farmer, K. Pflegerl, R.E.W. Hancock, M.L. Vasil and R.S. Hodges. Disruption of the b-sheet structure of cyclic peptides by single amino acid substitution: influence on prokaryotic and eukaryotic cell viability. In “Peptides: The Wave of the Future”, Proceedings of the Second International/Seventeenth American Peptide Symposium (M. Lebl and R.A. Houghten, Eds.), Kluwer Academic Publishers, pp. 477-478 (2001).
  3. Kondejewski, L.H., C. McInnes, M. Jelokhani-Niaraki, S.W. Farmer, C.M. Kay, B.D. Sykes, R.E.W. Hancock and R.S. Hodges.  Modulation of specificity in cyclic antimicrobial peptides by amphipathicity.  In Peptides for the New Millennium”, Proceedings of the Sixteenth American Peptide Symposium (G.B. Fields, J.P. Tam and G. Barany, Eds.), Kluwer Academic Publishers, pp. 752-753 (2000).
  4. Jelokhani-Niaraki, M., E.J. Prenner, L.H. Kondejewski, R.N. McElhaney, C.M. Kay and R.S. Hodges.  Interaction of Gramicidin S and its biologically active analogs with phospholipid bilayers. InPeptides for the New Millennium”, Proceedings of the Sixteenth American Peptide Symposium (G.B. Fields, J.P. Tam and G. Barany, Eds.), Kluwer Academic Publishers, pp. 740-741 (2000).
  5. Semchuk, P.D., M. Genest, L.H. Kondejewski and R.S. Hodges. Minimization of side reactions during removal of the formyl protecting group from the  amino group of lysine.  In “Peptides for the New Millennium”, Proceedings of the Sixteenth American Peptide Symposium (G.B. Fields, J.P. Tam and G. Barany, Eds.), Kluwer Academic Publishers, pp. 120-121 (2000).

1995-1999
  1. Jelokhani-Niaraki, M., L.H. Kondejewski, Y. Chen, R.E.W. Hancock, C.M. Kay and R.S. Hodges.  Structure and Biological Activity of Cyclic Peptides Based on Gramicidin S.  Proceedings of the 35th Japanese Peptide Symposium.  Peptide Science 1998:  M. Kondo (Ed.).  Protein Research Foundation, Osaka, pp. 81-84 (1999).
  2. Kondejewski, L.H., M. Jelokhani-Niaraki, E.J. Prenner, R.N.A.H. Lewis, R.N. McElhaney, R.E.W. Hancock and R.S. Hodges.  Design of cyclic antimicrobial peptides with low hemolytic activity.  InPeptide Science - Present and Future, Proceedings of the First International Peptide Symposium, Kluwer Academic Publishers, Y. Shimonishi, Ed., pp. 88-91 (1999).
  3. McMullen, T.P.W., E.J. Prenner, R.N.A.H. Lewis, L.H. Kondejewski, R.S. Hodges and R.N. McElhaney.  The interaction between gramicidin S and lipid bilayers:  Evidence for cholesterol attenuation of phospholipid-peptide interactions.  In Peptides:  Frontiers of Peptide Science, Proceedings of the Fifteenth American Peptide Symposium (J. Tam and P. Kaumaya, Eds.) Kluwer Academic Publishers, pp. 639-640 (1999).
  4. Kondejewski, L.H., M. Jelokhani-Niaraki, R.E.W. Hancock and R.S. Hodges.  Structure-activity relationships in cyclic ß-sheet antibacterial peptides.  In Peptides:  Frontiers of Peptide Science, Proceedings of the Fifteenth American Peptide Symposium (J. Tam and P. Kaumaya, Eds.) Kluwer Academic Publishers, pp. 152-153 (1999).
  5. Kondejewski, L.H., D.S. Wishart, B.D. Sykes, C.M. Kay and R.S. Hodges.  Design, synthesis and characterization of a peptide ß-sheet model.  In:   Peptides:  Chemistry, Structure and Biology, Proceedings of the Fourteenth American Peptide Symposium (P. Kaumaya and R.S. Hodges, Eds.) Mayflower Scientific Ltd., England, pp. 68-70 (1996).​

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2015-2019
NA

2010-2014
  1. Kirwan, J.P. and R.S. Hodges. Transmission of stability information through the N-domain of tropomyosin is interrupted by a stabilizing mutation (A109L) in the hydrophobic core of the stability control region (97-118). J. Biol. Chem. 389: 4356-4366 (2014).
  2. Kirwan, J.P. and R.S. Hodges.  Critical interactions in the stability control region of tropomyosin.  J. Structural Biology 170: 294-306 (2010).

2005-2009
  1. Schlegel, J., J.S. Redzic, C.C. Porter, V. Yurchenko, M. Bukrinsky, G.S. Armstrong, F. Zhang, N.G. Isern, J. DeGregori, R.S. Hodges and E.Z. Eisenmesser.  Solution characterization of the extracellular region of CD147 and its interaction with its enzyme ligand cyclophilin A. J. Mol. Biol. 391: 518-535 (2009).
  2. Hodges, R.S., J. Mills, S. McReynolds, J.P. Kirwan, B. Tripet, and D. Osguthorpe.  Identification of a unique “stability control region” that controls protein stability of tropomyosin:  a two-stranded a-helical coiled-coil.  J. Mol. Biol. 392: 747-762 (2009).
  3. Tsatskis, Y., S.C. Kwok, E. Becker, C. Gill, M. Smith, R.A.B. Keates, R.S. Hodges and J.M. Wood.    Core residue replacements cause coiled-coil orientation switching in vitro and in vivo: Structure-function correlations for osmosensory transporter ProP.  Biochemistry 47: 60-72 (2008).
  4. Smith, M.N., S.C. Kwok, R.S. Hodges and J.M. Wood.  Structural and Functional Analysis of Pro Q:  An osmoregulatory protein of Escherichia coli.  Biochemistry 46: 3084-3095 (2007).
  5. Wardell, S.E., S.C. Kwok, L. Sherman, R.S. Hodges, and D.P. Edwards.  Regulation of the amino-terminal transcription activation domain of progesterone receptor by a cofactor-induced protein folding mechanism.  Molecular Cellular Biology 25: 8792-8808 (2005).
  6. Rashid, D.J., J. Bononi, B. Tripet, R.S. Hodges and D.W. Pierce.  Monomeric and dimeric states exhibited by the kinesin-related motor protein KIFIA.  J. Peptide Research 65:  538-549 (2005).
  7. Chana, M., B. Tripet, C.T. Mant and R.S. Hodges.  Stability and specificity of heterodimer formation for the coiled-coil neck regions of the motor proteins Kif3A and Kif3B: The role of unstructured oppositely charged regions. J. Peptide Research 65:  209-220 (2005).

2000-2004
  1. Martin, S.L., M. Cruceanu, D. Branciforte, P. W.-L Li, S.C. Kwok, R.S. Hodges and M.C. Williams.  Line-1 Retrotransposition requires the nucleic acid chaperone activity of ORF1 Protein. J. Mol. Biol. 348, 549-561 (2005).
  2. Lindhout, D.A., J.R. Litowski, P. Mercier, R.S. Hodges and B.D. Sykes.  NMR solution structure of a highly stable de novo heterodimeric coiled-coil.  Peptide Science (Biopolymers) 75: 367-375 (2004).
  3. Kwok, S.C. and R.S. Hodges. Effect of chain length on coiled-coil stability: decreasing stability with increasing chain length. Biopolymers (Peptide Science) 76: 378-390 (2004).
  4. Kwok, S.C. and R.S. Hodges.  Stabilizing and Destabilizing Clusters in the Hydrophobic Core of Long Two-stranded a-Helical Coiled-Coils.  J. Biol. Chem. 279: 21576-21588 (2004).
  5. Lu, S.M. and R.S. Hodges. Defining the minimum size of a hydrophobic cluster in two-stranded a-helical coiled-coils: effects on protein stability. Protein Science 13: 714-726 (2004).
  6. Hillar, A., B. Tripet, D.L. Zoetewey, J.M. Wood, R.S. Hodges and J.M. Boggs. Detection of a-helical coiled-coil dimer formation by spin-labeled synthetic peptides: A model parallel coiled-coil peptide and the antiparallel coiled-coil formed by a replica of the ProP C-terminus.  Biochemistry42:15170-15178 (2003).
  7. Zoetewey, D.L., B. Tripet, T. Kutateladze, M. Overduin, J.M. Wood and R.S. Hodges. NMR solution structure of the cytoplasmic antiparallel coiled-coil domain from Escherichia coli ProP.  J. Mol. Biol. 334:1063-1076 (2003).
  8. Kwok, S.C. and R.S. Hodges. Clustering of large hydrophobes in the hydrophobic core of two-stranded coiled-coils controls protein folding and stability. J. Biol. Chem. 278: 35248-35254 (2003).
  9. Lee, D.L., S. Ivaninskii, P. Burkhard and R.S. Hodges. Unique stabilizing interactions identified in the two-stranded a-helical coiled-coils: Crystal structure of a cortexillin I/GCN4 hybrid coiled-coil peptide. Protein Sci. 12: 1395-1405 (2003).
  10. De Crescenzo, G., J.R. Litowski, R.S. Hodges and M.D. O’Connor-McCourt. Real-time monitoring of the interactions of de novo designed coiled-coils using Surface Plasmon Resonance: Effect of chain length on the kinetic and thermodynamic constants of interaction. Biochemistry 42: 1254-1263 (2003).
  11. Mant, C.T. and R.S. Hodges.  Design, synthesis and characterization of a-helices and coiled-coils.  In:  Synthesis of Peptides and Peptidomimetics.  Houben-Weyl Methods of Organic Chemistry (M. Goodman, A. Felix, L. Moroder and C. Toniolo, Eds.) Thieme Stuttgart, Vol. E22d: 68-113 (2003).
  12. Litowski, J.R. and R.S. Hodges. Designing heterodimeric two-stranded a-helical coiled-coils: The effects of hydrophobicity and a-helical propensity on protein folding, stability, and specificity. J. Biol. Chem277: 37272-37279 (2002).
  13. Tripet, B. and R.S. Hodges. Helix Capping Interactions Stabilize the N-terminus of the Kinesin Neck Coiled-coil. J. Structural Biology 137: 220-235 (2002).
  14. Chana, M., C.T. Mant, B. Tripet and R.S. Hodges. The role of unstructured highly charged regions on the stability and specificity of dimerization of two-stranded a-helical coiled-coils: Neck region of kinesin-like motor protein Kif3A. J. Structural Biology 137: 206-219 (2002).
  15. Chen, Y., C.T. Mant and R.S. Hodges. Determination of stereochemistry stability coefficients of amino acid side-chains in an amphipathic a-helix. J. Peptide Research 59: 18-33 (2002).
  16. Ho, C.-Y., M.E. Houston, J.G. Adamson, R.S. Hodges and M. Smith.  A possible mechanism for partitioning between homo- and hetero-dimerization of the yeast homeodomain proteins Mat a1 and Mat a2. J. Peptide Res 59: 34-43 (2002).
  17. Kwok. S.C., C.T. Mant and R.S. Hodges. Importance of Secondary Structural Specificity Determinants in Protein Folding: Insertion of a native b-sheet sequence into an a-helical coiled-coil. Protein Science 11: 1519-1531 (2002).
  18. Litowski, J.R. and R.S. Hodges. Designing heterodimeric two-stranded a-helical coiled-coils: The effect of chain length on protein folding, stability and specificity. J. Peptide Res. 58: 477-492 (2001).
  19. Baardsnes, J., M. Jelokhani-Niaraki, L.H. Kondejewski, M.J. Kuiper, C.M. Kay, R.S. Hodges and P.L. Davies. Antifreeze protein from Shorthorn Sculpin: Identification of the ice-binding surface. Protein Science 10: 2566-2576 (2001).
  20. Yu, B.Y., P.L. Privalov and R.S. Hodges.  Contribution of translational and rotational motions to molecular association and aqueous solution.  Biophys. J. 81: 1632-1642 (2001).
  21. Lee, D.L., P. Lavigne and R.S. Hodges. Are trigger sequences essential in the folding of two-stranded   a-helical coiled-coils?  J. Mol. Biol. 306:  539-553 (2001).
  22. Tripet, B., K. Wagschal, P. Lavigne, C.T. Mant and R.S. Hodges.  Effects of side-chain characteristics on the stability and oligomerization state of a de novo designed model coiled-coil:  Twenty amino acid substitutions in position "d".  J. Mol. Biol300:  377-402 (2000).
  23. Yu, B.Y., K.C. Wagschal, C.T. Mant and R.S. Hodges.  Trapping the Monomeric a-Helical State During Unfolding of Coiled-Coils by Reversed-Phase Chromatography.  J. Chromatogr. A. 890 81-94 (2000).
  24. Culham, D.E., B. Tripet, K.I. Racher, Voegele, R.T., R.S. Hodges and J.M. Wood.  The role of carboxyl terminal a-helical coiled-coil domain in osmosensing by transporter ProP of Escherichia coliJ. Mol. Recognit.13:  309-322 (2000).

1995-1999
  1. Baardsnes, J., L.H. Kondejewski, R.S. Hodges, H. Chao, C.M. Kay and P.L. Davies.  New ice-binding face for Type 1 antifreeze protein.  FEBS Letters 463: 87-91 (1999).
  2. Yu, B.Y., P. Lavigne, P.L. Privalov and R.S. Hodges.  A measure of disorder in a folded protein and its contribution to stability. J. Am. Chem. Soc. 121:  8443-8449 (1999).
  3. Wagschal, K., B. Tripet, P. Lavigne, C.T. Mant and R.S. Hodges.  The role of position "a" in determining the stability and oligomerization state of a-helical coiled-coils:  20 amino acid stability coefficients in the hydrophobic core of proteins.  Protein Sci. 8:  2312-2329 (1999).
  4. Loewen, M.C., H. Chao, M.E. Houston, J. Baardsnes, R.S. Hodges, C.M. Kay, B.D. Sykes, F.D. Sonnichsen and P.L. Davis.  Alternative roles for putative ice binding residues in Type 1 Antifreeze protein.  Biochemistry 38:  4743-4749 (1999).
  5. Yu, B.Y., P. Lavigne, C.M. Kay, R.S. Hodges and P.L. Privalov.  Contribution of translational and rotational entropy to the unfolding of a dimeric coiled-coil.  J. Physical Chemistry B 103:  2270-2278 (1999).
  6. Okamoto, P.M., B. Tripet, J. Litowski, R.S. Hodges and R.B. Vallee.  Multiple coiled-coils are involved in dyamin self-assembly.  J. Biol. Chem. 274:  10277-10286 (1999).
  7. Wagschal, K., B. Tripet and R.S. Hodges.  De novo design of a model peptide sequence to examine the effects of single amino acid substitutions in the hydrophobic core on both stability and oligomerization state of coiled-coils.  J. Mol. Biol. 285:  785-803 (1999).
  8. Kohn, W.D., C.M. Kay and R.S. Hodges.  Orientation, positional additivity and oligomerization state effects of interhelical ion-pairs in a-helical coiled-coils.  J. Mol. Biol. 283:  993-1012 (1998).
  9. Kohn, W.D. and R.S. Hodges.  De novo design of a-helical coiled-coils and bundles:  Protein models for development of design principles.  Trends in Biotechnology 16:  379-389 (1998).
  10. Lavigne, P., M.P. Crump, S.M. Gagne, R.S. Hodges, C.M. Kay and B.D. Sykes.  Insights into the Mechanism of heterodimerization from the 1H-NMR solution structure of the c-MYC-MAX heterodimeric leucine zipper.  J. Mol. Biol. 281:  165-181 (1998).
  11. Kwok, S.C., B. Tripet, J.H. Man, M. Chana, P. Lavigne, C.T. Mant and R.S. Hodges.  Structural cassette mutagenesis in a de novo designed protein:  Proof of a novel concept for examining protein folding and stability.  Biopolymers (Peptide Science) 47:101-123 (1998).
  12. Kohn, W.D., C.M. Kay and R.S. Hodges.  Effects of Lanthanide binding on the stability of de novodesigned a-helical coiled-coils.  J. Peptide Research 51:  9-18 (1998).
  13. Houston, M.E., H. Chao, R.S. Hodges, B.D. Sykes, C.M. Kay, F.D. Sönnichsen, M.C. Loewen and P.L. Davies.  Binding of an oligopeptide to a specific plane of ice.  J. Biol. Chem. 273:  11714-11718 (1998).
  14. Kohn, W.D., C.M. Kay, B.D. Sykes and R.S. Hodges.  Metal ion-induced folding of a de novodesigned coiled-coil peptide.  J. Am. Chem. Soc. 120:  1124-1132 (1998).
  15. Chao, H., D.L. Bautista, J. Litowski, R.T. Irvin and R.S. Hodges.  The use of a heterodimeric coiled-coil system for biosensor application and affinity purification. J. Chromatography B 715: 307-329 (1998).
  16. Chao, H., M.E. Houston, R.S. Hodges, C.M. Kay, B.D. Sykes, M.C. Loewen, P.L. Davies and F.D. Sönnichsen.  A diminished role for hydrogen bonds in antifreeze protein binding to ice.  Biochemistry 36:  14652-14660 (1997).
  17. De Crovy-Chanel, A., R.S. Hodges, M. Kohiyama and G. Richarme.  DNAJ potentiates the interaction of DNAK with a-helical peptides.  BBRC 233:  627-630 (1997).
  18. Kohn, W.D., C.M. Kay and R.S. Hodges.  Salt effects on the protein stability:  Two-stranded a-helical coiled-coils containing inter- or intrahelical ion-pairs.  J. Mol. Biol. 267:  1039-1052 (1997).
  19. Tripet, B., R.D. Vale and R.S. Hodges.  Demonstration of coiled-coil interactions within the kinesin neck region using synthetic peptides:  Implications for motor activity.  J. Biol. Chem. 272:   8946-8956 (1997).
  20. Wallace, A., E. Bianchi, M.E. Houston, R.S. Hodges and A. Pessi.  Topographical mimics of a structured peptide selected from a conformationally-homogeneous peptide combinatorial library.  In:  Innovations and Perspectives in Solid-Phase Synthesis (R. Epton, Ed.), pp. 553-556, Escom Scientific Publications, Leiden, The Netherlands (1997).
  21. Lavigne, P., M.P. Crump, S.M. Gagné, B.D. Sykes, R.S. Hodges and C.M. Kay.  1H-NMR Evidence for Two Buried Asn Side-Chains in the c-Myc-Max Heterodimeric a-Helical Coiled-coil.  In:Techniques in Protein Chemistry VIII (D.R. Marshak, Ed.) Academic Press Inc. pp. 617-624 (1997).
  22. Kohn, W.D., C.T. Mant and R.S. Hodges. a-Helical protein assembly motifs.  J. Biol. Chem. 272: 2583-2586 (1997).
  23. Kohn, W.D., C.M. Kay and R.S. Hodges.  Positional dependence of the effects of negatively charged Glu side-chains on the stability of two-stranded a-helical coiled-coils.  J. Peptide Sci. 3:  209-223 (1997).
  24. Chao, H., M.E. Houston, S. Grothe, C.M. Kay, M. O'Connor-McCourt, R.T. Irvin and R.S. Hodges.  Kinetic study on the formation of a de novo designed heterodimeric coiled-coil:  Use of surface plasmon resonance to monitor the association and dissociation of polypeptide chains.  Biochemistry 35:  12175-12185 (1996).
  25. Houston, M.E., P. Campbell, B. Lix, C.M. Kay, B.D. Sykes and R.S. Hodges.  Lactam bridge stabilization of a-helices:  The role of hydrophobicity in controlling dimeric versus monomeric a-helices. Biochemistry 35:  10041-10050 (1996).
  26. Court, D.A., F.E. Nargang, H. Steiner, R.S. Hodges, W. Neupert and R. Lill.  Role of the intermembrane space domain of the preprotein receptor Tom 22 in protein import into mitochondria.  Molecular and Cellular Biology 16:  4035-4042 (1996).
  27. Chao, H., R.S. Hodges, C.M. Kay, S.Y. Gauthier and P.L. Davies.  A natural variant of type I antifreeze protein with four ice-binding repeats is a particularly potent antifreeze.  Protein Science5:  1150-1156 (1996).
  28. Rothemund, S.E., E. Krause, M. Beyermann, M. Dathe, M. Bienert, R.S. Hodges, B.D. Sykes, F.D. Sönnichsen.  Peptide destabilization by D-amino acids in single-stranded amphipathic a-helices.  Peptide Research 9:  79-87 (1996).
  29. Tripet, B., L. Yu, D. Bautista, W.Y. Wong, R.T. Irvin and R.S. Hodges.  Engineering a de novodesigned coiled-coil dimerization domain for rapid detection, purification and characterization of recombinant peptides and proteins.  Protein Engineering 9:  1029-1042 (1996).
  30. Houston, M.E., A. Wallace, E. Bianchi, A. Pessi and R.S. Hodges.  Use of conformationally restricted secondary structural element to display peptide libraries:  A two-stranded a-helical coiled-coil stabilized by lactam bridges.  J. Mol. Biol. 262:  270-282 (1996).
  31. Yu, B.Y., O.D. Monera, R.S. Hodges and P.L. Privalov.  Investigation of electrostatic interactions in two-stranded coiled-coils through residue shuffling.  Biophysical Chemistry 59:  299-314 (1996).
  32. Monera, O.D., F.D. Sonnichsen, L. Hicks, C.M. Kay and R.S. Hodges.  The relative positions of alanine residues in the hydrophobic core control the formation of two-stranded or four-stranded a-helical coiled-coils.  Protein Engineering 9:  353-363 (1996).
  33. Hodges, R.S.  De novo design of a-helical proteins:  Basic research to medical applications.  Can. Soc. Biochemistry and Mol. Biol. Boehringer Mannheim Award Lecture.  Biochem. Cell Biology 74: 133-154 (1996).
  34. Monera, O.D., N.E. Zhou, P. Lavigne, C.M. Kay and R.S. Hodges.  Formation of parallel and antiparallel coiled-coils controlled by the relative positions of alanine residues in the hydrophobic core.  J. Biol. Chem. 271:  3995-4001 (1996).
  35. Yu, B.Y., O.D. Monera, R.S. Hodges and P.L. Privalov.  Ion-pairs significantly stabilize coiled-coils in the absence of electrolyte.  J. Mol. Biol. 255:  367-372 (1996).
  36. Lavigne, P., F.D. Sönnichsen, C.M. Kay and R.S. Hodges.  Interhelical salt-bridges, coiled-coil stability and specificity of dimerization.  Science 271:  1136-1138 (1996).
  37. Rothemund, S., M. Beyerman, E. Krause, G. Krause, M. Bienert, R.S. Hodges, B.D. Sykes and F.D. Sönnichsen.  Structure effects of double D-amino acid replacements:  A NMR and CD study using amphipathic model helices.  Biochemistry 34:  12954-12962 (1995). 
  38. Kohn, W.D., O.D. Monera, C.M. Kay and R.S. Hodges.  The effects of interhelical electrostatic repulsions between glutamic acid residues in controlling the dimerization and stability of two-stranded a-helical coiled-coils.  J. Biol. Chem. 270:  25495-25506 (1995).
  39. Lavigne, P., L.H. Kondejewski, M.E. Houston, F.D. Sönnichsen, B. Lix, B.D. Sykes, R.S. Hodges and C.M. Kay.  Preferential heterodimeric parallel coiled-coil formation by synthetic Max and C-Myc leucine zippers:  A description of putative electrostatic interactions responsible for the specificity of interaction.  J. Mol. Biol. 254:  505-520 (1995).
  40. Monera, O.D., T.J. Sereda, N.E. Zhou, C.M. Kay and R.S. Hodges.  Relationship of side-chain hydrophobicity and a-helical propensity on the stability of the single-stranded amphipathic a-helix.  J. of Peptide Science 1:  319-329 (1995).
  41. Houston, M.E., C.L. Gannon, C.M. Kay and R.S. Hodges.  Lactam bridge stabilization of a-helical peptides:  Ring size, orientation, and positional effects.  J. Peptide Science 1:  274-282 (1995).
  42. Kohn, W.D., C.M. Kay and R.S. Hodges.  Protein destabilization by electrostatic repulsions in the two-stranded a-helical coiled-coil/leucine zipper.  Protein Science 4:  237-250 (1995).

1990-1994
  1. Su, J.Y., R.S. Hodges and C.M. Kay.  Effect of chain length on the formation and stability of synthetic a-helical coiled-coils.  Biochemistry  33:  15501-15510 (1994).
  2. Zhou, N.E., C.M. Kay and R.S. Hodges.  The net energetic contribution of interhelical electrostatic attractions to coil-coil stability.  Protein Engineering 7:  1365-1372 (1994).
  3. Monera, O.D., C.M. Kay and R.S. Hodges.  Protein denaturation with guanidine hydrochloride or urea provides a different estimate of stability depending on the contributions of electrostatic interactions.  Protein Science 3:  1984-1991 (1994).
  4. Zhou, N.E., O.D. Monera, C.M. Kay and R.S. Hodges. a-Helical propensities of amino acids in the hydrophobic face of an amphipathic a-helix.  Protein and Peptide Letters  1: 114-119, 1994.
  5. Ho, C.-Y., J.G. Adamson, R.S. Hodges and M. Smith.  Heterodimerization of the yeast Mat a1 and Mat a2 proteins is mediated by two leucine zipper like coiled-coil motifs.  The EMBO Journal 13:  1403-1413 (1994).
  6. Monera, O.D., C.M. Kay and R.S. Hodges.  Electrostatic interactions control the parallel and antiparallel orientation of a-helical chains in two-stranded a-helical coiled-coils.  Biochemistry 33: 3862-3871 (1994).
  7. Zhou, N.E., C.M. Kay and R.S. Hodges.  The role of interhelical ionic interactions in controlling protein folding and stability:  De novo designed synthetic two-stranded a-helical coiled-coils.  J. Molecular Biology  237:  500-512 (1994).
  8. Adamson, J.G., N.E. Zhou and R.S. Hodges.  Structure, function and application of the coiled-coil protein folding motif.  Current Opinion in Biotechnology 4:  428-437 (1993).
  9. Mant, C.T., N.E. Zhou and R.S. Hodges.  The role of amphipathic helices in stabilizing peptide and protein structure. The Amphipathic Helix (R.M. Epand, Ed.), CRC Press Inc. pp. 39-64 (1993).
  10. Monera, O.D., N.E. Zhou, C.M. Kay and R.S. Hodges.  Comparison of antiparallel and parallel two-stranded a-helical coiled-coils:  Design, synthesis and characterization.  J. Biol. Chem. 268: 19218-19227 (1993).
  11. Zhu, B.-Y., N.E. Zhou, C.M. Kay and R.S. Hodges.  Packing and hydrophobicity effects on protein folding and stability.  Effects of ß-branched amino acids, valine and isoleucine, on the formation and stability of two-stranded a-helical coiled-coils/leucine zippers.  Protein Science  2:  383-394 (1993).
  12. Zhou, N.E., C.M. Kay, B.D. Sykes and R.S. Hodges.  A single-stranded amphipathic a-helix in aqueous solution:  Design, structural characterization and its application for determining a-helical propensities of amino acids.  Biochemistry  32: 6190-6197 (1993).
  13. Zhou, N.E., C. M. Kay and R.S. Hodges.  Disulfide bond contribution to protein stability:  Positional effects of substitution in the hydrophobic core of the two-stranded a-helical coiled-coil.  Biochemistry 32:  3178-3187 (1993).
  14. Zhu, B.-Y., N.E. Zhou, P.D. Semchuk, C.M. Kay and R.S. Hodges.   Design, synthesis and structural characterization of model heterodimeric coiled-coil proteins.  Int. J. Pept. Pro. Res. 40:  171-179 (1992).
  15. Zhou, N.E., C.M. Kay and R.S. Hodges.  Synthetic model proteins:  The relative contribution of leucine residues at the non-equivalent positions of the 3-4 hydrophobic repeat to the stability of the two-stranded a-helical coiled-coil.  Biochemistry  31:  5739-5746 (1992).
  16. Zhou, N.E., B.-Y. Zhu, B.D. Sykes and R.S. Hodges.  The relationship between amide proton chemical shifts and hydrogen bonding in amphipathic a-helical peptides.  J. Am. Chem. Soc. 114:  4320-4326 (1992).
  17. Zhou, N.E., B.-Y. Zhu, C.M. Kay and R.S. Hodges.  The two-stranded a-helical coiled-coil is an ideal model for studying protein stability and subunit interactions.  Biopolymers 32: 419-426 (1992).
  18. Hodges, R.S.  Unzipping the secrets of coiled-coils.  Current Biology 2: 122-124 (1992).
  19. Zhou, N.E., C.M. Kay and R.S. Hodges.  Synthetic model proteins:  Positional effects of interchain hydrophobic interactions on stability of two-stranded a-helical coiled-coils.  J. Biol. Chem.  267:2664-2670 (1992).
  20. Hodges, R.S., N.E. Zhou, C.M. Kay and P.D. Semchuk. Synthetic model proteins:  Contribution of hydrophobic residues and disulfide bonds to protein stability. Peptide Research  3: 123-137 (1990).

1985-1989
  1. Hodges, R.S., P.D. Semchuk, A.K. Taneja, C.M. Kay, J.M.R. Parker and C.T. Mant.  Protein design using model synthetic peptides.  Peptide Research  1, 19-30 (1988).
  2. Gillespie, L.L., C. Argan, A.K. Taneja, R.S. Hodges, K.B. Freeman and G.C. Shore. A synthetic signal peptide blocks import of precursor proteins destined for the mitochondrial inner membrane or matrix. J. Biol. Chem. 260: 16045-16048 (1985).

1980-1984
  1. Lau, S.Y.M., A.K. Taneja and R.S. Hodges. Synthesis of a model protein of defined secondary and quaternary structure: Effect of chain length on the stabilization and formation of two-stranded a-helical coiled-coils. J. Biol. Chem. 259: 13253-13261 (1984).
  2. Hofmann, T., R.S. Hodges and M.N.G. James. Effect of pH on the activities of pencillopepsin  and Rhizopus-pepsin and a proposal for the productive substrate binding mode in pencillopepsin. Biochemistry  23: 635-643 (1984).
  3. Talbot, J.A. and R.S. Hodges. Tropomyosin: A model protein for studying coiled-coil  and a-helix stabilization.  Acc. Chem. Res. 15: 224-230 (1982).
  4. Hodges, R.S., A.K. Saund, P.C.S. Chong, S.A. St.-Pierre and R.E. Reid. Synthetic model for two-stranded a-helical coiled-coils. Design, synthesis and characterization of an 86-residue analog of tropomyosin.  J. Biol. Chem. 256: 1214-1224 (1981).
1975-1979
  1. Hodges, R.S. Synthetic a-helical coiled-coils.  Polymer Preprints  20: 51-54 (1979).
  2. St.-Pierre, S.A. and R.S. Hodges. The solution synthesis of sequential polypeptides as models for the double-stranded coiled-coil structure of tropomyosin.  Can. J. Biochem.  55:  636-643 (1977).
  3. Sodek, J., R.S. Hodges and L.B. Smillie. Amino acid sequence of rabbit skeletal muscle a-tropomyosin.  J. Biol. Chem. 253: 1129-1136 (1978).

1970-1974
  1. Hodges, R.S. and R.B. Merrifield. A synthetic study of the effect of tyrosine at position 120 of ribonuclease.  Int. J. Peptide Prot. Res. 6: 397-405 (1974).
  2. Merrifield, R.B. and R.S. Hodges.  Synthetic approaches to the study of proteins. Proceedings of the International Symposium on Macromolecules,  Rio de Janeiro, 1974. Elsevier: Amsterdam  (1975), pp. 417-431.
  3. Hodges, R.S. and R.B. Merrifield. The role of serine-123 in the activity and specificity of ribonuclease-reactivation of ribonuclease 1-118 by the synthetic COOH-terminal tetradeca-peptide; ribonuclease 111-124 and its O-methyl serine and alanine analogs.  J. Biol. Chem. 250: 1231-1241 (1975).
  4. St.-Pierre, S.A. and R.S. Hodges. A sequential polyheptapeptide as a model for the double-stranded a-helical coiled-coil structure of tropomyosin.  Biochem. Biophys. Res. Commun. 72: 581-588 (1976).
  5. Hodges, R.S. and L.B. Smillie. Chemical evidence for chain heterogeneity in rabbit muscle tropomyosin. Biochem. Biophys. Res. Commun.  41: 987-994 (1970).
  6. Hodges, R.S. and L.B. Smillie. Cysteine sequences of rabbit skeletal tropomyosin.  Can. J. Biochem.  50: 330-343 (1972).
  7. Hodges, R.S. and L.B. Smillie.  The histidine and methionine sequences of rabbit skeletal tropomyosin.  Can. J. Biochem. 50: 312-329 (1972).
  8. Hodges, R.S., J. Sodek and L.B. Smillie. The cyanogen bromide fragments of rabbit skeletal tropomyosin. Biochem. J. 128: 102P (1972).
  9. Hodges, R.S., J. Sodek, L.B. Smillie and L. Jurasek. Tropomyosin: amino acid sequence and coiled-coil structure.  Cold Spring Harbor Symp. Quant. Biol. 37: 299-310 (1972).
  10. Sodek, J., R.S. Hodges, L.B. Smillie and L. Jurasek.  Amino acid sequence of rabbit skeletal tropomyosin and its coiled-coil structure.  Proc. Nat. Acad. Sci. U.S.A. 69: 3800-3804 (1972).
  11. Hodges, R.S. and L.B. Smillie. Cyanogen bromide fragments of rabbit skeletal tropomyosin.  Can. J. Biochem. 51: 56-70 (l973).

Proceedings Publications

2015-2019
NA

2010-2014
  1. Kirwan, J.P. and R.S. Hodges.  Global versus regional stability in tropomyosin: propagation of single-mutation effects through a rod-like protein.  In Peptides: Building Bridges (M. Lebl, Ed.), Proceedings of the 22nd American Peptide Symposium, San Diego, CA, pp. 140-141 (2011).

2005-2009
  1. Kirwan, J.P., S.C. Kwok, S. McReynolds, J. Mills, D. Osguthorpe and R.S. Hodges.  Unique Role of Clusters of Electrostatic Attractions in Controlling the Stability of Two-stranded a-Helical Coiled-coils.  In Peptides for Youth, Proceedings of the 20th American Peptide Symposium, Montreal, Quebec, Canada (2007). (S. Del Valle, E. Escher, W.D. Lubell, (Eds) Springer p. 77-78 (2009) and Adv. Exp. Med. Biol. 611: 77-78 (2009).
  2. Kirwan, J.P., S.C. Kwok, D. Osguthorpe and R.S. Hodges.  Stability control sites in two-stranded a-helical coiled-coils.  Proceedings of the 4th International Peptide Symposium in conjunction with the 7th Australian peptide Conference and the 2nd Asia-Pacific International Peptide Symposium, Cairns, Queensland, Australia (2007)  (http://www.peptideoz.org) K220 (2008).
  3. Mills, J.B., S.C. Kwok, L.B. Smillie and R.S. Hodges.  Identification of a Unique Stability Propagation Site that Controls Protein Stability of a-Tropomyosin:  a two-stranded a-helical coiled-coil.  In Understanding Biology Using Peptides:  Proceedings of the 19th American Peptide Symposium.  San Diego, CA (2005) (S.E. Blondelle, Ed.)  Springer Science, New York, NY  pp 581-582 (2006).
  4. Zoetewey, D.L., D.N.M. Jones, J.M. Wood and R.S. Hodges.  Preliminary NMR Analysis of ProP 440-500 the C-terminal Cytoplasmic Domain of Bacterial Osmosensory Protein ProP.  In Understanding Biology Using Peptides:  Proceedings of the 19th American Peptide Symposium.  San Diego, CA (2005) (S.E. Blondelle, Ed.)  Springer Science, New York, NY  pp 258-260 (2006).

2000-2004
  1. Zoetewey, D.L., B. Tripet, T.G. Kutateladze, M.J. Overduin, J.M. Wood and R.S. Hodges.  Cytoplasmic domain of E. coli ProP forms an antiparallel coiled-coil as determined by NMR spectroscopy.  In Peptide Revolution:  Genomics, Proteomics and Therapeutics, Proceedings of the Eighteenth American Peptide Symposium Boston, MA (2003) (M. Chorev and T. K. Sawyer, Eds.) American Peptide Society pp. 301-302 (2004).
  2. Lu, S.M., S.C. Kwok and R.S. Hodges.  Importance of hydrophobic clusters on protein folding and stability. In Peptide Revolution:  Genomics, Proteomics and Therapeutics, Proceedings of the Eighteenth American Peptide Symposium Bobston, MA (2003) (M. Chorev and T. K. Sawyer, Eds.) American Peptide Society pp. 409-411 (2004).
  3. Kwok, S.C. and R.S. Hodges.  Effect of chain length on coiled-coil stability: Decreasing stability with increasing chain length.  In Peptide Revolution:  Genomics, Proteomics and Therapeutics, Proceedings of the Eighteenth American Peptide Symposium Boston, MA (2003) (M. Chorev and T. K. Sawyer, Eds.) American Peptide Society pp. 490-492 (2004).
  4. Chen, Y., C.T. Mant and R.S. Hodges. The determination of helix stability coefficients using D-amino acid substitutions in the non-polar face of an amphipathic a-helical model peptide. In“Peptides: The Wave of the Future”, Proceedings of the Second International/Seventeenth American Peptide Symposium (M. Lebl and R.A. Houghten, Eds.), Kluwer Academic Publishers, pp. 353-354 (2001).
  5. Chana, M., B. Tripet and R.S. Hodges. The role of unstructured highly charged regions on the stability and specificity of dimerization of two-stranded a-helical coiled-coils: Neck region of kinesin-like motor protein Kif3A. In “Peptides: The Wave of the Future”, Proceedings of the Second International/Seventeenth American Peptide Symposium (M. Lebl and R.A. Houghten, Eds.), Kluwer Academic Publishers, pp. 359-360 (2001).
  6. Tripet, B. and R.S. Hodges. A Leu-Thr-Trp-Lys “lock” stabilizes the N-terminus of the kinesin neck coiled-coil. In “Peptides: The Wave of the Future”, Proceedings of the Second International/Seventeenth American Peptide Symposium (M. Lebl and R.A. Houghten, Eds.), Kluwer Academic Publishers, pp. 361-362 (2001).
  7. Tripet, B. and R.S. Hodges. STABLECOIL: An algorithm designed to predict the location and relative stability of coiled-coils in native protein sequences. In “Peptides: The Wave of the Future”, Proceedings of the Second International/Seventeenth American Peptide Symposium (M. Lebl and R.A. Houghten, Eds.), Kluwer Academic Publishers, pp. 365-366 (2001).
  8. Kwok, S.C., C.T. Mant and R.S. Hodges. Lactam-bridged and disulfide-bridged peptide mimic of a stable a-helical folded protein. In “Peptides: The Wave of the Future”, Proceedings of the Second International/Seventeenth American Peptide Symposium (M. Lebl and R.A. Houghten, Eds.), Kluwer Academic Publishers, pp. 377-378 (2001).
  9. Lu, S.M., J.R. Litowski, B. Tripet and R.S. Hodges. Homostranded and heterostranded a-helical templates for combinatorial library display: Differences in stability and solubility. In “Peptides: The Wave of the Future”, Proceedings of the Second International/Seventeenth American Peptide Symposium (M. Lebl and R.A. Houghten, Eds.), Kluwer Academic Publishers, pp. 466-467 (2001).
  10. Litowski, J.R. and R.S. Hodges. Designing heterodimeric a-helical coiled-coils: The effect of chain length on protein folding, stability and specificity. In Peptides 2000, Proceedings of the 26th European Peptide Symposium (J. Martinez and J.A. Fehrentz, eds.). EDK Publishers, Paris, France. pp. 499-500 (2001).
  11. Kwok, S.C., C.T. Mant and R.S. Hodges.  Importance of secondary structure specificity determinants in protein folding and stability. In Peptides for the New Millennium”, Proceedings of the Sixteenth American Peptide Symposium (G.B. Fields, J.P. Tam and G. Barany, Eds.), Kluwer Academic Publishers, pp. 277-279 (2000).
  12. Litowski, J.R. and R.S. Hodges.  The design of heterodimeric coiled-coil domains for diagnostic display systems.  In “Peptides for the New Millennium”, Proceedings of the Sixteenth American Peptide Symposium (G.B. Fields, J.P. Tam and G. Barany, Eds.), Kluwer Academic Publishers, pp. 285-286 (2000).
  13. Lee, D.L., Y. Chen, K.C. Wagschal, S. McKenna, B. Harland, C.T. Mant and R.S. Hodges.  Effect of D-amino acid substitutions on amphipathic -helical structure. In Peptides for the New Millennium”, Proceedings of the Sixteenth American Peptide Symposium (G.B. Fields and G. Barany, Eds.), Kluwer Academic Publishers, pp. 289-290 (2000).
  14. Yu, B.Y., P. Lavigne, P. Privalov and R.S. Hodges. Rotamer number revealed as another parameter to gauge the quality of packing in folded proteins. In Peptides for the New Millennium”, Proceedings of the Sixteenth American Peptide Symposium (G.B. Fields, J.P. Tam and G. Barany, Eds.), Kluwer Academic Publishers, pp. 318-319 (2000).

1995-1999
  1. Houston, M.E., R.T. Irvin and R.S. Hodges.  Design and synthesis of a lactam bridged stabilized coiled-coil template for library display.  In Peptide Science - Present and Future, Proceedings of the First International Peptide Symposium.  Kluwer Academic Publishers, Y. Shimonishi (Ed.), pp. 128-131 (1999).
  2. Kwok, S.C., C.T. Mant and R.S. Hodges.  Effects of a-helical and b-sheet propensities of amino acids on protein stability.  In Peptides 98, Proceedings of the 25th European Peptide Symposium (Bajusz, S., and Hudecz, F., Eds.).  Publisher:  Akadémiai Kiadó, Budapest, pp. 34-35 (1999).
  3. Houston, M.E., H. Chao, M.C. Loewen, F.D. Sonnichsen, C.M. Kay, B.D. Sykes and R.S. Hodges.  A New paradigm for fish antifreeze protein binding to ice.  In Peptides:  Frontiers of Peptide Science, Proceedings of the Fifteenth American Peptide Symposium (J. Tam and P. Kaumaya, Eds.) Kluwer Academic Publishers, pp. 747-748 (1999).
  4. Lavigne, P., L.H. Kondejewski, M.E. Houston, R.S. Hodges and C.M. Kay.  On the energetics of the heterodimerization of Max and c-Myc Leucine Zippers.  In Peptides:  Frontiers of Peptide Science, Proceedings of the Fifteenth American Peptide Symposium (J. Tam and P. Kaumaya, Eds.) Kluwer Academic Publishers, pp. 467-468 (1999).
  5. Wagschal, K.C., B. Tripet, P. Lavigne and R.S. Hodges.  De Novo design of a-helical coiled-coils:  the effect on stability of amino acid substitution in the hydrophobic core.  In Peptides:  Frontiers of Peptide Science, Proceedings of the Fifteenth American Peptide Symposium (J. Tam and P. Kaumaya, Eds.) Kluwer Academic Publishers, pp. 82-84 (1999).
  6. Kohn, W.D., C.M. Kay and R.S. Hodges.  Metal ion-induced folding of a de novo designed a-helical coiled-coil.  In Peptides:  Frontiers of Peptide Science, Proceedings of the Fifteenth American Peptide Symposium (J. Tam and P. Kaumaya, Eds.) Kluwer Academic Publishers, pp. 134-135 (1999).
  7. Houston, M.E., C.M. Kay and R.S. Hodges.  Lactam bridge stabilization of a-helices and enhancement of dimerization.  In:   Peptides:  Chemistry, Structure and Biology, Proceedings of the Fourteenth American Peptide Symposium (P. Kaumaya and R.S. Hodges, Eds.) Mayflower Scientific Ltd., England, pp. 549-551 (1996).
  8. Kohn, W.D., O.D. Monera, C.M. Kay and R.S. Hodges.  The effects of different salts on the role of interhelical electrostatic repulsions in the stability of two-stranded a-helical coiled-coils.  In:  Peptides:  Chemistry, Structure and Biology, Proceedings of the Fourteenth American Peptide Symposium (P. Kaumaya and R.S. Hodges, Eds.) Mayflower Scientific Ltd., England, pp. 829-830 (1996).
  9. Lavigne, P., L.H. Kondejewski, M.E. Houston, F.D. Sönnichsen, R.S. Hodges and C.M. Kay.  Synthetic max and c-myc leucine zippers preferentially form a heterodomeric parallel coiled-coil.  In:   Peptides:  Chemistry, Structure and Biology, Proceedings of the Fourteenth American Peptide Symposium (P. Kaumaya and R.S. Hodges, Eds.) Mayflower Scientific Ltd., England, pp. 863-864 (1996).
  10. Tripet, B., N. Zhou, F. Sönnichsen and R.S. Hodges.  Hybritein 1:  A de novo designed protein displaying cooperative interactions between a metal binding loop and a helix-helix dimerization motif.  In "Peptides 1994", Proceedings of the 23rd European Peptide Symposium (H.L.S. Maia, Ed.), Escom Science Publishers, Leiden, The Netherlands, pp. 79-80 (1995).

1990-1994
  1. Monera, O.D., N.E. Zhou, C.M. Kay and R.S. Hodges.  Parallel or antiparallel alignment of a-helical chains in two-stranded coiled-coils is controlled by interchain electrostatic interactions.  In:   Peptides:  Chemistry, Structure and Biology, Proceedings of the Thirteenth American Peptide Symposium (R.S. Hodges and J.A. Smith, Eds.), Escom Science Publishers, Leiden, The Netherlands, pp.1057-1059 (1994).
  2. Zhou, N.E., C.M. Kay and R.S. Hodges.  The role of interchain ionic interactions in protein folding and stability of two-stranded a-helical coiled-coils.  In:   Peptides:  Chemistry, Structure and Biology, Proceedings of the Thirteenth American Peptide Symposium (R.S. Hodges and J.A. Smith, Eds.), Escom Science Publishers, Leiden, The Netherlands, pp.1069-1071 (1994).
  3. Zhou, N.E., B.-Y. Zhu, C.M. Kay and R.S. Hodges.  Importance of intra-chain ionic interactions in stabilizing a-helices in proteins.  In Peptides:  Biology and Chemistry (Proceedings of the 1992 Chinese Peptide Symposium), (Y.-C. Du, J.P. Tam and Y.-S. Zhang, Eds.), Escom Science Publishers, Leiden, The Netherlands, pp.217-220 (1993).
  4. Zhou, N.E., C.M. Kay and R.S. Hodges.  Synthetic model proteins: Positional effects of interchain a-helical hydrophobic interactions on protein conformation and stability.  In "Peptides: Chemistry and Biology",  Proceedings of the 12th American Peptide Symposium (J. Smith and J.E. Rivier, Eds.) Escom Science Publishers, The Netherlands (1992) 323-325.
  5. Semchuk, P.D., C.M. Kay and R.S. Hodges.  Synthetic a-helical model proteins: Contribution of hydrophobic residues to protein stability.  In "Peptides: Chemistry, Structure and Biology".  Proceedings of the Eleventh American Peptide Symposium (J.E. Rivier and G.R. Marshall, Eds.), Escom Science Publishers, The Netherlands (1990) pp. 566-570.

1975-1979
  1. Hodges, R.S., S.A. St.-Pierre and F.-S. Tjoeng. Synthetic sequential polyheptapeptides as models for the two-stranded a-helical coiled-coil structure of tropomyosin. In "Peptides - Proceedings of the Fifth American Peptide Symposium (Eds. Goodman, M. and J. Meienhofer) John Wiley & Sons, Inc., pp. 411-414 (1977).​

​​​​
2015-2019
NA

2010-2014
NA

2000-2004
  1. Tripet, B., G. DeCrescenzo, S. Grothe, M. O’Connor-McCourt, and R.S. Hodges. Kinetic analysis of the interactions between Troponin C and Troponin I binding peptides: Evidence for separate binding sites between the ‘structural’ N-terminus and the ‘regulatory’ C-terminus of TnI with TnC. J. Mol. Recog. 16: 37-53 (2003).
  2. Tripet, B., G. DeCrescenzo, S. Grothe, M. O’Connor-McCourt, and R.S. Hodges. Kinetic analysis of the interactions between Troponin C and the C-terminal Troponin I Regulatory Region and validation of a new peptide delivery/capture system used for surface plasmon resonance. J. Mol. Biol. 323: 345-362 (2002).
  3. Ngai, S.-M., J.R. Pearlstone, C.S. Farah, F.C. Reinach, L.B. Smillie and R.S. Hodges.  Structural and functional studies on troponin I and troponin C interactions. J. Cell. Biochem. 83: 33-46 (2001).
  4. Ngai, S.-M., J.R. Pearlstone, L.B. Smillie and Robert S. Hodges.  Characterization of the biologically important interaction between troponin C and the N-terminal region of troponin I. J. Cell. Biochem. 83: 99-110 (2001).
  5. Blumenschein, T.M.A., B. Tripet, R.S. Hodges and B.D. Sykes. Mapping the interacting regions between troponins T and C: Binding of TnT and TnI peptides to TnC and NMR mapping of the TnT-binding site on TnC. J. Biol. Chem. 276: 36606-36612 (2001).

1995-1999
  1. Van Eyk, J.E., F. Powers, W. Law, C. Larue, R.S. Hodges and R.J. Solaro.  Breakdown and Release of Myofilament Proteins During Ischemia and Ischemia/Reperfusion in Rat Hearts:  Identification of Degradation Products and Effects on the pCa-Force Relation.  Circulation Research 82:  261-271 (1998).
  2. McKay, R.T., B. Tripet, R.S. Hodges and B.D. Sykes.  Interaction of the Second Binding Region of Troponin I with the Regulatory Domain of Skeletal Muscle Troponin C as Determined by NMR Spectroscopy.  J. Biol. Chem. 272:  28494-28500 (1997).
  3. Tripet, B., J.E. Van Eyk and R.S. Hodges.  Mapping of a Second Actin-Tropomyosin and a Second Troponin C Binding Site within the C-terminus of Troponin I, and their importance in the Ca2+-Dependent Regulation of Muscle Contraction.  J. Mol. Biol. 271:  728-750 (1997).
  4. Van Eyk, J.E., R.A. Caday-Malcolm, L. Yu, R.T. Irvin and R.S. Hodges.  Anti-peptide monoclonal antibody imaging of a common binding domain involved in muscle regulation.  Protein Science 4: 781-790 (1995).
  5. Van Eyk, J.E., L.T. Thomas, B. Tripet, R.J. Wiesner, J.C. Rüegg, J.R. Pearlstone, C.S. Farah, F.C. Reinach and R.S. Hodges.  Distinct regions of troponin I regulate Ca2+-dependent potentiation and Ca2+-sensitivity of the acto-S1-TM ATPase activity of the thin filament.  J. Biol. Chem. 272: 10529-10537 (1997).

1990-1994
  1. Shaw, G.S., R.S. Hodges, C.M. Kay and B.D. Sykes.  Relative stabilities of synthetic peptide homo- and heterodimeric troponin-C domains.  Protein Science  3:  1010-1019 (1994).
  2. Van Eyk, J.E. and R.S. Hodges.  The use of synthetic peptides to unravel the mechanism of muscle regulation.  In "Synthetic Peptides as Probes in Protein-Protein Interactions" (Ed. H.E. Hamm).  As part of "Methods:  A Companion to Methods in Enzymology", Academic Press, 5, 264-280 (1993).
  3. Ngai, S.-M., F.D. Sönnichsen and R.S. Hodges.  Photochemical crosslinking between native rabbit skeletal troponin C and Benzoylbenzoyl-Troponin I inhibitory peptide, residues 104-115.  J. Biol. Chem. 269:  2165-2172 (1994).
  4. Van Eyk, J.E., J.D. Strauss, R.S. Hodges and J.C. Rüegg.  A synthetic peptide mimics troponin I function in the calcium-dependent regulation of muscle contraction.  FEBS 323:  223-228 (1993).
  5. Blechner, S.L., G.A. Olah, N.C.J. Strynadka, R.S. Hodges and J. Trewhella.  4Ca2+-troponin C forms dimers in solution at neutral pH that dissociate upon binding various peptides:  Small-angle X-ray scattering studies of peptide-induced structural changes.  Biochemistry 31:  11326-11334 (1992).
  6. Campbell, A.P., J.E. Van Eyk, R.S. Hodges and B.D. Sykes.  Interaction of troponin I and troponin C:  Use of the two-dimensional NMR transferred Overhauser effect to determine the structure of a Gly -110 inhibitory troponin I peptide analog when bound to cardiac troponin C.  Biochimica Biophysica Acta. 1160:  35-54 (1992).
  7. Ngai, S.-M. and R.S. Hodges.  Biologically important interactions between synthetic peptides of the N-terminal region of TnI and TnC.  J. Biol. Chem. 267:  15715-15720 (1992).
  8. Shaw, G.S., W.A. Findlay, P.D. Semchuk, R.S. Hodges and B.D. Sykes.  Specific formation of a heterodimeric two-site calcium-binding domain from synthetic peptides.  J. Am. Chem. Soc. 114: 6258-6259 (1992).
  9. Sönnichsen, F.D., J.E. Van Eyk, R.S. Hodges and B.D. Sykes.  The effect of trifluorethanol on protein secondary structure:  An NMR and CD study using a synthetic actin peptide.  Biochemistry 31:  8790-8798 (1992).
  10. Shaw, G.S., R.S. Hodges and Brian D. Sykes.  Determination of the solution structure of a synthetic two-site calcium-binding homodimeric protein domain by NMR spectroscopy.  Biochemistry 31:  9572-9580 (1992).
  11. Monera, O.D., G.S. Shaw, B.-Y. Zhu, B.D. Sykes, C.M. Kay and R.S. Hodges.  The role of interchain a-helical hydrophobic interactions on Ca2+-affinity formation and stability of a two-site domain in troponin C.  Protein Science  1:  945-955 (1992).
  12. Shaw, G.S., R.S. Hodges and B.D. Sykes.  Stoichiometry of calcium binding to a synthetic heterodimeric troponin-C domain.  Biopolymers  32: 391-397 (1992).
  13. Shaw, G.S., R.S. Hodges and B.D. Sykes.  Calcium-induced folding of troponin-C: Formation of homodimeric and heterodimeric two-site domains from synthetic peptides.  In "Techniques in Protein Chemistry III", Academic Press, Inc. (R.H. Angeletti, Ed.) 347-353 (1992).
  14. Van Eyk, J. and R.S. Hodges.  A synthetic peptide of the N-terminus of actin interacts with myosin.  Biochemistry 30: 11676-11682 (1991).
  15. Shaw, G.S., R.S. Hodges and B.D. Sykes.  Probing the relationship between a-helix formation and calcium affinity in troponin-C: 1H-NMR studies in calcium binding to synthetic and variant site III helix-loop-helix peptides. Biochemistry30: 8339-8347 (1991).
  16. Shaw, G.S., L.F. Golden, R.S. Hodges and B.D. Sykes.  Interactions between paired calcium-binding sites in proteins: NMR determination of the stoichiometry of calcium binding to a synthetic troponin-C peptide.  J. Am. Chem. Soc. 113: 5557-5563 (1991).
  17. Van Eyk, J.E., F.D. Sönnichsen, B.D. Sykes and R.S. Hodges.  Interaction of actin 1-28 with myosin and troponin I and the importance of these interactions to muscle regulation.  In "Peptides as Probes in Muscle Research"  (C. Rüegg, Ed.) Springer-Verlag (1991) pp.15-31.
  18. Rüegg, J.C. C. Zeugner, J.E. Van Eyk, R.S. Hodges and I.P. Trayer.  Myosin and troponin peptides affect calcium sensitivity of skinned muscle fibres.  In "Peptides as Probes in Muscle Research" (C. Rüegg, Ed.) Springer-Verlag (1991) pp.95-109.
  19. Van Eyk, J.E., C.M. Kay and R.S. Hodges.  A comparative study of the interactions of synthetic peptides of the skeletal and cardiac TnI inhibitory region with skeletal and cardiac TnC.  Biochemistry30: 9974-9981 (1991).
  20. Campbell, A.P., B.J. Marsden, J. Van Eyk, R.S. Hodges and B.D. Sykes.  Calcium regulation of muscle contraction; NMR studies of the interaction of troponin C with calcium and troponin I.  In"Frontiers of NMR in Molecular Biology", UCLA Symposia on Molecular and Cellular Biology, New Series, Volume 109 (D. Live, I. Armitage and D. Patel, editors).  Alan R. Liss, Inc., New York, N.Y. (1990) pp. 99-108.
  21. Shaw, G.S., R.S. Hodges, B.D. Sykes.  Calcium-induced peptide association to form an intact protein domain: 1H NMR structural evidence.  Science  249: 280-283 (1990).

1985-1989
  1. Rüegg, J.C., C. Zeugner, J. Van Eyk, C.M. Kay and R.S. Hodges.  Inhibition of TnI-TnC interaction and contraction of skinned muscle fibres by the synthetic peptide, TnI (104-115).  Eur. J. Physiol. 414: 430-436 (1989).
  2. Marsden, B.J., R.S. Hodges and B.D. Sykes.  A 1H NMR determination of the solution conformation of a synthetic peptide analog of calcium-binding site III of rabbit skeletal troponin C.  Biochemistry  28: 8839-8847 (1989).
  3. Ingraham, R.H. and R.S. Hodges.  The effects of Ca2+ and subunit interactions on surface accessibility of Cys residues in cardiac troponin. Biochemistry  27: 5891-5898 (1988).
  4. Marsden, B.J., R.S. Hodges and B.D. Sykes. 1H NMR studies of synthetic peptide analogues of calcium-binding site III of rabbit skeletal troponin C. The effect on the lanthanum affinity of the interchange of Asp and Asn residues at the metal-ion coordinating positions.  Biochemistry  27: 4198-4206 (1988).
  5. Watson, M.H., A.K. Taneja, R.S. Hodges and A.S. Mak. Phosphorylation of aa- and ßß-tropomyosin and synthetic peptide analogs. Biochemistry  27: 4506-4512 (1988).
  6. Van Eyk, J.E. and R.S. Hodges.  The biological importance of each amino acid residue of the troponin I inhibitory sequence 104-115 in the interaction with troponin C and tropomyosin-actin. J. Biol. Chem. 263: 1726-1732 (1988).
  7. Hodges, R.S. Structural studies on calmodulin and troponin C.  Recueil  (J. Royal Netherlands Chemical Society) 106: 263 (1987).
  8. Van Eyk, J. and R.S. Hodges. Calmodulin and troponin C:  Affinity chromatographic study of divalent cation requirements for troponin I inhibitory peptide [104-115], mastoparan and flu-phenazine binding. Biochemistry and Cell Biology  65: 982-988 (1987).
  9. Marsden, B.J., R.S. Hodges and B.D. Sykes.  The effect on the metal-binding affinity of total charge and charge permutation at the liganding positions of synthetic calcium-binding analogues of site III of rabbit skeletal troponin C.  In "Calcium Binding Proteins in Health and Disease" (Norman, A.W., Vanaman, T.C. and Means, A.R., Eds.) Academic Press, Inc. (1987) pp. 412-414.
  10. Cachia, P.J., J. Van Eyk, R.H. Ingraham, W.D. McCubbin, C.M. Kay and R.S. Hodges.  Calmodulin and troponin C:  A comparative study of the interaction of mastoparan and troponin I inhibitory peptide [104-115]. Biochemistry  25: 3553-3562 (1986).
  11. Van Eyk, J., P.J. Cachia, R.H. Ingraham and R.S. Hodges. Studies on the regulatory complex  of rabbit skeletal muscle: Contributions of troponin subunits and tropomyosin in the presence and absence of Ca2+ and Mg2+ on the acto-S1-ATPase activity. J. Protein Chem. 5: 335-354 (1986).
  12. Cachia, P.J., J. Gariepy and R.S. Hodges. Structural studies on calmodulin and troponin C: Phenothiazine, peptide and protein interactions with calcium-induced helices. In  "Calmodulin Antagonists and Cellular Physiology" (H. Hidaka and D.J. Hartshorne, eds.), Academic Press, Chapter 5, pp. 63-88 (1985).
  13. Gariepy, J., L.E. Kay, I.D. Kuntz, B.D. Sykes and R.S. Hodges. Nuclear magnetic resonance determination of metal-proton distances in a synthetic calcium binding site of rabbit skeletal troponin C. Biochemistry  24: 544-550 (1985).

1980-1984
  1. Shelling, J., M.E. Bjornson, R.S. Hodges, A.K. Taneja and B.D. Sykes.  Contact and di-polar contributions to lanthanide induced NMR shifts of amino acid and peptide models for  calcium binding sites in proteins. J. Magnetic Res. 57: 99-114 (1984).
  2. Gariepy, J. and R.S. Hodges. Primary sequence analysis and folding behavior of EF hands in relation to mechanism of action of troponin C and calmodulin. FEBS Lett.  160: 1-6 (1983).
  3. Hodges, R.S., P.C.S. Chong and P.J. Asselbergs. Inhibition of rabbit skeletal muscle acto-S1-tropomyosin ATPase by troponin T. In  "Calcium Binding Proteins in Health and Disease" (E. Carafoli  et al., eds.) Elsevier Biomedical  Press, pp.385-386 (1983)
  4. Gariepy, J., B.D. Sykes and R.S. Hodges. Lanthanide-induced geometry of a synthetic calcium binding analog of site III of troponin C. In  "Calcium Binding Proteins in Health and Disease" (E. Carafoli  et al., eds.) Elsevier  Biomedical Press, pp.387-388 (1983).
  5. Chong, P.C.S., P.J. Asselbergs and R.S. Hodges. Inhibition of rabbit skeletal muscle acto-S1 ATPase by troponin T. FEBS Lett.  153: 372-376 (1983).
  6. Reid, R.E., J. Gariepy and R.S. Hodges. Interaction of neuroleptic drugs with a synthetic calcium binding peptide analog of site III of troponin C: Phenothiazine selective binding. FEBS Lett.  154: 60-64 (1983).
  7. Cachia, P.J., B.D. Sykes and R.S. Hodges.  Calcium-dependent inhibitory region of troponin: A proton magnetic resonance study on the interaction between troponin C and the synthetic peptide Na-acetyl [FPhe106] TnI (104-115) Amide. Biochemistry  22: 4145-4152 (1983).
  8. Gariepy, J. and R.S. Hodges. Localization of a trifluoperazine binding site on Troponin C.  Biochemistry  22: 1586-1594 (1983).
  9. Gariepy, J., B.D. Sykes and R.S. Hodges. Lanthanide induced peptide folding: Variations in lanthanide affinity and induced peptide conformation.  Biochemistry  22: 1765-1772 (1983).
  10. Chong, P.C.S. and R.S. Hodges. Photochemical cross-linking between rabbit skeletal troponin  subunits: Troponin I-troponin T interactions.  J. Biol. Chem. 257: 11667-11672 (1982).
  11. Chong, P.C.S. and R.S. Hodges. Proximity of sulfhydryl groups to the sites of interaction between components of the troponin complex from rabbit skeletal muscle.  J. Biol. Chem. 257: 2549-2555 (1982).
  12. Gariepy, J., B.D. Sykes, R.E. Reid and R.S. Hodges. Proton nuclear magnetic resonance investigation of synthetic calcium-binding peptides.  Biochemistry  21: 1506-1512 (1982).
  13. Chong, P.C.S. and R.S. Hodges. Photochemical cross-linking between rabbit skeletal troponin and a-tropomyosin.  Attachment of the photoaffinity probe N-(4-azidobenzoyl-[2-3H]glycyl-5-(2-thiopyridyl)-cysteine to cysteine 190 of a-tropomyosin.  J. Biol. Chem. 257: 9152-9160 (1982).
  14. Talbot, J.A. and R.S. Hodges.  Comparative studies on the inhibitory region of selected species of Tn-I: The use of synthetic peptide analogs to probe structure-function relationships.  J. Biol. Chem. 256: 12374-12378 (1981).
  15. Reid, R.E., J. Gariepy, A.K. Saund and R.S. Hodges. Calcium-induced protein folding.  Structure-affinity relationships in synthetic analogs of the helix-loop-helix calcium binding unit.  J. Biol. Chem. 256: 2742-2751 (1981).
  16. Talbot, J.A. and R.S. Hodges. Synthetic studies on the inhibitory region of rabbit skeletal troponin I. Relationship of amino acid sequence to biological activity.  J. Biol. Chem. 256:2798-2802 (1981).
  17. Reid, R.E. and R.S. Hodges. Cooperativity and calcium/magnesium binding to troponin C and muscle calcium binding parvalbumin: an hypothesis.  J. Theoretical Biol. 84: 401-444 (1980).
  18. Reid. R.E., D.M. Clare and R.S. Hodges. Synthetic analog of a high affinity calcium binding site in rabbit skeletal troponin C. J. Biol. Chem. 255: 3642-3646 (1980).
  19. Reid, R.E., J. Gariepy, A.K. Saund and R.S. Hodges. Synthetic Ca2+ binding peptides: Ca2+ induced folding. In  "Calcium-Binding Proteins:  Structure and Function". (Eds. F.L. Siegel, E. Carafoli, R.H. Kretsinger, D.H. MacLennan and R.H.  Wasserman) Elsevier North Holland Inc., pp. 337-341 (1980).
1975-1979
  1. Talbot, J.A. and R.S. Hodges. Synthesis and biological activity of an icosapeptide analog of the actomyosin ATPase inhibitory region of Tn-I.  J. Biol. Chem. 254: 3720-3723 (1979).
​​
Proceedings Publications

2015-2019
NA

2010-2014
  1. Mant, C.T., Z. Jiang, B. E. Boyes and R.S. Hodges. An improved approach to hydrophilic interaction chromatography of peptides: Salt gradients in the presence of high isocratic acetonitrile concentrations. J. Chromatography A 1277: 15-25 (2013). PMC3639484 PMID23332786

1990-1994
  1. Ngai, S.-M., F.D. Sönnichsen and R.S. Hodges.  Photochemical cross-linking between native rabbit skeletal troponin C and benzoylbenzoyl-TnI inhibitory peptide, residues 104-115.  In:   Peptides:  Chemistry, Structure and Biology, Proceedings of the Thirteenth American Peptide Symposium (R.S. Hodges and J.A. Smith, Eds.), Escom Science Publishers, Leiden, The Netherlands, pp.951-953 (1994).
  2. Van Eyk, J.E., J.D. Strauss, R. Weisner, R.S. Hodges and J.C. Rüegg.  A single amino acid substitution in the troponin I inhibitory peptide alters the calcium responsiveness of reconstituted troponin I-depleted skinned cardiac muscle fibers.  In:   Peptides:  Chemistry, Structure and Biology, Proceedings of the Thirteenth American Peptide Symposium (R.S. Hodges and J.A. Smith, Eds.), Escom Science Publishers, Leiden, The Netherlands, pp.966-967 (1994).
  3. Van Eyk, J.E., O.D. Monera and R.S. Hodges.  Probing the functional importance of the amino acid residues in the synthetic peptide actin 1-28 on interaction with Troponin I and Myosin.  In:  Peptides:  Chemistry, Structure and Biology, Proceedings of the Thirteenth American Peptide Symposium (R.S. Hodges and J.A. Smith, Eds.), Escom Science Publishers, Leiden, The Netherlands, pp.961-962 (1994).
  4. Monera, O.D., G.S. Shaw, B.D. Sykes, C.M. Kay and R.S. Hodges.  Effect of hydrophobic residues in the N- and C-terminal a-helices of the synthetic Ca2+ binding site III of TnC on Ca2+-affinity and formation and stability of a dimeric two-site domain.  In "Peptides: Chemistry and Biology", Proceedings of the 12th American Peptide Symposium (J. Smith and J.E. Rivier, Eds.).  Escom Science Publishers, The Netherlands (1992) 341-343.
  5. Shaw, G.S., R.S. Hodges and B.D. Sykes.  Synthetic calcium-binding peptides which form heterodimeric two-site domains.  In "Peptides: Chemistry and Biology" (J. Smith and J.E. Rivier, Eds.), Proceedings of the 12th American Peptide Symposium, Escom Science Publishers, The Netherlands (1992) 209-212.
  6. Monera, O., P.D. Semchuk, K. Oikawa, G.S. Shaw, N.J. Strynadka, C.M. Kay, B.D. Sykes and R.S. Hodges.  Design of a model protein with a single Ca2+-binding site and enhanced metal ion affinity.  Peptides 1990, (Proceedings of the 21st European Peptide Symposium) (E. Giralt and D. Andreu, eds.) Escom Science Publishers B.V. Leiden, The Netherlands, 570-573.​
​​​​
2015-2019
  1. Mant, C.T. and R.S. Hodges. Separation of peptides on HALO 2-micron particles. Current Protocols in Protein Science 85: 11.6.1-11.6.16 (2016). doi:10.1002/cpps.12 (Wileyonlinelibrary.com, John Wiley & Sons, Inc.).

2010-2014
  1. Huang, Y.B., L. Pan, L.J. Zhao, C.T. Mant, R.S. Hodges and Y. Chen. Structure-guided RP-HPLC chromatography of diastereomeric α-helical peptide analogs substituted with single amino acid stereoisomers. Biomed. Chromatogr. 28: 511-517 (2014). No PMC PMID24127254 DOI 10.1002/bmc.3061
  2. Zajdowicz, S., J.C. Haller, A.E. Krafft, S.W. Hunsucker, C.T. Mant, M.W. Duncan, R.S. Hodges, D.N.M. Jones, and R.K.Holmes. Purification and Structural Characterization of Siderophore (Corynebactin) from Corynebacterium diphtheriae. PLoS one 2012; 7(4) e34591. PMC3326035 PMID22514641
  3. Mant, C.T. and R.S. Hodges. Design of peptide standards with the same composition and minimal sequence variation to monitor performance/selectivity of reversed-phase matrices. J. Chromatography A , 1230: 30-40 (2012). PMC3294100 PMID22326185
  4. Mant, C.T., D. Cepeniene and R.S. Hodges. Reversed-phase HPLC of Peptides: Assessing column and solvent selectivity on standard, polar embedded and polar end-capped columns.  J. Separation Science 33:3005-3021 (2010).

2005-2009
  1.  Mant, C.T., J.M. Kovacs, H.M. Kim, D.D. Pollock and R.S. Hodges.  Intrinsic amino acid side-chain hydrophilicity/hydrophobicity coefficients determined by reversed-phase high-performance liquid chromatography of model peptides: comparison with other hydrophilicity/hydrophobicity scales.  Biopolymers (Peptide Science) 92: 573-595 (2009).
  2. Mant, C.T. and R.S. Hodges. Mixed-mode hydrophilic interaction/cation exchange chromatography: separation of complex mixtures of peptides of varying charge and hydrophobicity.  J. Separation Science 31:  1573-1584 (2008).
  3. Mant, C.T. and R.S. Hodges.  Mixed-mode hydrophilic interaction/cation exchange chromatographic (HILIC/CEX) separation of peptides and proteins.  J. Separation Science 31: 2754-2773 (2008).
  4. Tripet, B., D. Cepeniene, J.M. Kovacs, C.T. Mant, O.V. Krokhin and R.S. Hodges.  Requirements for prediction of peptide retention time in reversed-phase high-performance liquid chromatography:  hydrophobicity/hydrophilicity of side-chains at the N- and C-termini of peptides are dramatically affected by end-groups and location.  J. Chromatography A 1141:  212-225 (2007).
  5. Chen, Y., C.T. Mant and R.S. Hodges.  Preparative reversed-phase high performance liquid chromatography of an antimicrobial peptide on columns of varying diameters (1 mm to 9.4 mm).  J. Chromatography A 1140: 112-120 (2007).
  6. Popa, T., C.T. Mant and R.S. Hodges.  Ion-Interaction Capillary Zone Electrophoresis:  The presence of high concentrations of ion-pairing reagents demonstrates the complex mechanisms involved in peptide separations. Special issue on Capillary Electrophoresis (CE) and Capillary Electrochromatography (CEC) of Amino Acids, Peptides and Proteins.  Electrophoresis 28:2181-2190 (2007).
  7. Tripet, B., M. RenukaJayadev, D. Blow, C. Nguyen, R.S. Hodges and K.J. Cios.  Proteomic Data Mining Using Predicted Peptide Chromatographic Retention Times.  The International Journal of Bioinformatics Research and Applications.  IJBRA. 3:431-445 (2007).
  8. Mant, C.T., Y. Chen, Z. Yan, T.V. Popa, J.M. Kovacs, J.B. Mills, B. Tripet and R.S. Hodges. HPLC Analysis and Purification of Peptides.  In “Peptide Characterization and Application,” Methods in Molecular Biology Series (Ed. G.B. Fields) Humana Press 386: 3-55 (2007).
  9. Mant, C.T. and R.S. Hodges.  Context-dependent effects on the hydrophilicity/hydrophobicity of side-chains during reversed-phase high-performance liquid chromatography:  implications for prediction of peptide retention behavior.  J. Chromatography A 1125:  211-219 (2006).
  10. Mills, J.B., C.T. Mant, and R.S. Hodges.  One-step purification of recombinant proteins from a whole cell extract by reversed-phase high-performance liquid chromatography.  J. Chromatogr. A. 1133: 248-253 (2006).
  11. RenukaJayadev, M., D. Blow, B. Tripet, R.S. Hodges and K.J. Cios.  Proteomic Data Mining Using Predicted Peptide Chromatographic Retention Times. Proc. of the Biotechnology and Bioinformatics Symposium (BIOT-06), Brigham Young University, Provo, Utah, October 20-21; 84-89 (2006).
  12. Kovacs, J.M., C. T. Mant, D. J. Osguthorpe, S.C. Kwok, R. S. Hodges. Quantitation of the nearest-neighbour effects of amiono acid side-chains that restrict conformational freedom of the polypeptide chain using reversed-phase liquid chromatography of synthetic model peptides with L- and D- amino acid substitutions. J. Chromatography A 1123:  212-224 (2006).
  13. Kovacs, J.M.,  C.T. Mant and R.S. Hodges. Determination of the intrinsic hydrophilicity/hydrophobicity of amino acid side-chains in peptides in the absence of Nearest-Neighbor or Conformational Effects. Peptide Science (Biopolymers) 84: 298-309 (2006).
  14. Popa, T.V., C.T. Mant and R.S. Hodges.  Ion interaction capillary zone electrophoresis (II-CZE) of cationic proteomic peptide standards.  J. Chromatography A 1111: 192-199 (2006).
  15. Shibue, M., C.T. Mant and R.S. Hodges. Effect of anionic ion-pairing reagent hydrophobicity on selectivity of peptide separations by reversed-phase chromatography. J. Chromatography A 1080: 68-75 (2005).
  16. Shibue, M., C.T. Mant and R.S. Hodges. Effect of anionic ion-pairing reagent concentration (1 mM – 60 mM) on reversed-phase chromatography elution behavior of peptides. J. Chromatography A1080:  58-67 (2005).
  17. Shibue, M., C.T. Mant and R.S. Hodges. The perchlorate anion is more effective than trifluoroacetate anion as a ion-pairing reagent for reversed-phase chromatography of peptides. J. Chromatography A 1080: 49-57 (2005).

2000-2004
  1. Hodges, R.S., Y. Chen, E. Kopecky, and C.T. Mant. Monitoring the hydrophilicity/hydrophobicity of amino acid side-chains in the non-polar and polar faces of amphipathic a-helices by reversed-phase and mixed-mode hydrophilic interaction/cation-exchange chromatography.  J. Chromatography A 1053: 161-172 (2004).
  2. Popa, T.V., C.T. Mant, Y. Chen and R.S. Hodges, Capillary zone electrophoresis (CZE) of a-helical diastereomeric peptide pairs using anionic ion-pairing reagents. J. Chromatography A 1043: 113-122 (2004).
  3. Chen, Y., A.R. Mehok, C.T. Mant and R.S. Hodges. Optimum concentration of trifluoroacetic acid (TFA) for reversed-phase chromatography of peptides revisited. J. Chromatography A 1043: 9-18 (2004).
  4. Popa, T.V., C.T. Mant and R.S. Hodges. Capillary electrophoresis of cationic random coil peptide standards:  effect of anionic ion-pairing reagents and comparison with reversed-phase chromatography.  Electrophoresis 25: 1219-1229 (2004).
  5. Chen, Y., C.T. Mant and R.S. Hodges. Selectivity differences in the separation of amphipathic a-helical peptides during reversed-phase chromatography at pH 2.0 and pH 7.0: effects of different packings, mobile phase conditions and temperature. J. Chromatography A 1043: 99-111 (2004).
  6. Popa, T.V., C.T. Mant and R.S. Hodges. Capillary electrophoresis of amphipathic a-helical peptide diastereomers. Electrophoresis 25: 94-107 (2004).
  7. Hartmann, E., Y. Chen, C.T. Mant, A. Jungbauer and R.S. Hodges. Comparison of reversed-phase liquid chromatography and hydrophilic interaction/cation-exchange chromatography for the separation of amphipathic a-helical peptides with L- and D-amino acid substitutions in the hydrophilic face. J. Chromatography A. 1009:61-71 (2003).
  8. Mant, C.T., Y. Chen and R.S. Hodges. Temperature profiling of polypeptides in reversed-phase liquid chromatography: I. Monitoring of dimerization and unfolding of amphipathic a-helical peptides. J. Chromatography A. 1009:29-43 (2003).
  9. Mant, C.T., B. Tripet and R.S. Hodges. Temperature profiling of polypeptides in reversed-phase liquid chromatography: II. Monitoring of folding and stability of two-stranded a-helical coiled-coils. J. Chromatography A. 1009:45-59 (2003).
  10. Lee, D.L., C.T. Mant and R.S. Hodges. A novel method to measure self-association of small amphipathic molecules: Temperature profiling in reversed-phase chromatography. J. Biol. Chem.278: 22918-22927 (2003).
  11. Chen, Y., C.T. Mant and R.S. Hodges. Temperature selectivity effects in reversed-phase liquid chromatography due to conformation differences between helical and non-helical peptides. J. Chromatogr. A. 1010:45-61 (2003).
  12. Popa, T.V., C.T. Mant and R.S. Hodges. Capillary electrophoresis of synthetic peptide standards varying in charge and hydrophobicity. Electrophoresis 24:4197-4208 (2003).
  13. Mant, C.T. and R.S. Hodges. Reversed-phase liquid chromatography as a tool in the determination of the hydrophilicity/hydrophobicity of amino acid side-chains at a ligand-receptor interface in the presence of different aqueous environments:  I. Effect of varying receptor hydrophobicity. J. Chromatogr. A 972: 45-60 (2002).
  14. Mant, C.T. and R.S. Hodges.Reversed-phase liquid chromatography as a tool in the determination of the hydrophilicity/hydrophobicity of amino acid side-chains at a ligand-receptor interface in the presence of different aqueous environments:  II. Effect of varying peptide ligand hydrophobicity. J. Chromatogr. A 972: 61-75 (2002).
  15. Mant, C.T. and R.S. Hodges. Preparative reversed-phase chromatography of proteins from a multi-protein complex: rabbit skeletal troponin. J. Chromatogr. A 972: 101-114 (2002).
  16. Mehok, A.R., C.T. Mant, L. Gera, J. Stewart  and R.S. Hodges. Preparative reversed-phase chromatography of peptides: isocratic two-step elution system for high loads on analytical columns. J. Chromatogr. A 972: 87-99 (2002).
  17. Mant, C.T. and R.S. Hodges. Analytical HPLC of Peptides. In "HPLC of Biological Macromolecules: Methods and Applications" (Second Edition) (K. Gooding and F. Regnier, Eds). Marcel Dekker, Inc. New York, N.Y. pp 433-511 (2002).
  18. Mant, C.T. and R.S. Hodges.  Liquid Chromatography [Hydrophilic interaction/cation-exchange chromatography of peptides].  In Encyclopedia of Separation Science (Academic Press), Editors I.D. Wilson, T.R. Adland, C.F. Poole and M. Cook. pp. 3615-3626 (2000).
  19. Husband, D., C.T. Mant and R.S. Hodges.  Development of simultaneous purification methodology for multiple synthetic peptides by reversed-phase sample displacement chromatography.  J. Chromatogr. A 893, 81-94 (2000).

1995-1999
  1. Litowski, J.R., P.D. Semchuk, C.T. Mant and R.S. Hodges.  Hydrophilic interaction/cation-exchange chromatography for the purification of synthetic peptides from closely related impurities:  Serine side-chain acetylated peptides.  J. Peptide Research 54:1-11 (1999).
  2. D'Agostino, P.A., J.R. Hancock, L.R. Provost, P.D. Semchuk and R.S. Hodges.  Liquid chromatographic high resolution mass spectrometric and tandem mass spectrometric identification of synthetic peptides using electrospray ionization.  J. Chromatography A 800:  89-100 (1998).
  3. Mant, C.T., L.H. Kondejewski and R.S. Hodges.  Hydrophilic interaction/cation-exchange chromatography for separation of cyclic peptides.  J. Chromatography A 816:  79-88 (1998).
  4. Mant, C.T., J.R. Litowski and R.S. Hodges.  Hydrophilic interaction/cation exchange chromatography for separation of amphipathic a-helical peptides.  J. Chromatography A 816:  65-78 (1998).
  5. Mant, C.T., H. Chao and R.S. Hodges.  Effect of mobile phase on the oligomerization state of a-helical coiled-coil peptides during high-performance size-exclusion chromatography.  J. Chromatography A  791:  85-98 (1997).
  6. Holm, A., S. Ostergaard, R.S. Hodges, D. Husband and S. Buus.  Multiple Peptide Synthesis on Resin Immunol.  Methods Manual 2:  847-851 (1997).
  7. Sereda, T.J., C.T. Mant and R.S. Hodges.  Use of sodium perchlorate at low pH for peptide separations by reversed-phase chromatography.  Influence of perchlorate ion on apparent hydrophilicity of positively charged side-chains.  J. Chromatography A 776:  153-165 (1997).
  8. Mant, C.T., L.H. Kondejewski, P.J. Cachia, O.D. Monera and R.S. Hodges.  Analysis of Synthetic Peptides by High-Performance Liquid Chromatography.  In "Solid-Phase Peptide Synthesis" a volume of Methods in Enzymology, Vol. 289, pp. 426-469 (1997).
  9. Hanson, M., K.K. Unger, C.T. Mant and R.S. Hodges.  Optimization strategies in ultrafast reversed-phase chromatography of proteins.  Trends Anal. Chem. 15:  102-110 (1996).
  10. Godel, J.C., T.K. Basu, H.F. Pabst, R.S. Hodges, P.E. Hodges and M.L. Ng.  Perinatal vitamin A (retinal) status of Northern Canadian mothers and their infants:  Effects of age and race.  Biol. Neonate 69:  133-139 (1996).
  11. Mant, C.T. and R.S. Hodges.  Analysis of peptides by HPLC.  In "High Resolution Separation of Biological Macromolecules Part B Applications" (B.L. Karger and W.S. Hancock, Eds.), a volume of Methods of Enzymology, Academic Press, San Diego, CA, 271:  3-50 (1996).
  12. Wang, J., R.S. Hodges and B.D. Sykes.  Generating multiple conformations of flexible peptides in solution based on NMR nuclear overhauser effect data:  Application to desmopressin.  J. Am. Chem. Soc. 117:  8627-8634 (1995).
  13. Wang, J., R.S. Hodges and B.D. Sykes.  Effect of trifluoroethanol on the solution structure and flexibility of desmopressin:  A two-dimensional NMR study.  Int. J. Peptide Protein Res. 45:  471-481 (1995).
  14. D'Agostino, P.A., J.R. Hancock, L.R. Provost, P.D. Semchuk and R.S. Hodges.  High resolution electrospray mass spectrometry with a magnetic sector instrument:  Accurate mass measurement and peptide sequencing.  Rapid Commun. in MS 9:  597-603 (1995).
  15. Sereda, T.J., C.T. Mant and R.S. Hodges.  Selectivity due to conformational differences between helical and non-helical peptides in reversed-phase chromatography.   J. Chromatog. A. 695:  205-221 (1995).
  16. Wishart, D.S., C.G. Bigam, A. Holm, R.S. Hodges and B.D. Sykes.  1H, 13C and 15N random coil NMR chemical shifts of the common amino acids:  I.  Investigations of nearest neighbor effects.  J. Biomolecular NMR Today  5:  67-81 (1995).

1990-1994
  1. Mant, C.T., T.W.L. Burke and R.S. Hodges.  A rapid, simple approach to predicting effects of varying run parameters on reversed-phase gradient elution profiles of peptides.  LC.GC 12:396-404 (1994).
  2. Hodges, R.S., B.-Y. Zhu, N.E. Zhou and C.T. Mant.  Reversed-phase chromatography as a useful probe of hydrophobic interactions involved in protein folding and protein stability.  J. Chromatography A 676:  3-15 (1994).
  3. Sereda, T.J., C.T. Mant, F.D. Sönnichsen and R.S. Hodges.  Reversed-phase chromatography of synthetic amphipathic a-helical peptides as a model for ligand-receptor interactions:  Effect of changing hydrophobic environment on the relative hydrophilicity/hydrophobicity of amino acid side-chains.  J. Chromatography 676:  139-153 (1994).
  4. Parker, J.M.R. and R.S. Hodges.  Homology plot: Searching for homology to a family of proteins using a database of unique conserved patterns. J. Computer-Aided Molecular Design  8:  193-210 (1994).
  5. Sereda, T.J., C.T. Mant, A.M. Quinn and R.S. Hodges.  Effect of the a-amino group on peptide retention behavior in reversed-phase chromatography:  Determination of the pKa values of the a-amino group of 19 different N-terminal amino acid residues.  J. Chromatography  646:  17-30 (1993).
  6. Hodges, R.S., T.W.L. Burke, A.J. Mendonca and C.T. Mant.  Preparative reversed-phase sample displacement chromatography of peptides.  In "Chromatography in Biotechnology" American Chemical Soc. Symposium Series 529, Chapter 5, pp. 59-76 (C. Horvath and L.S. Ettre,  Eds.) (1993).
  7. Wang, J., F.D. Sönnichsen, R. Boyko, R.S. Hodges and B.D. Sykes.  Evaluation of NMR based structure determination of flexible peptides:  Application to desmopressin.  In Techniques in Protein Chemistry IV,pp. 569-575 (1993).  Academic Press Inc.
  8. Hanson, M., K.K. Unger, C.T. Mant and R.S. Hodges.  Polymer-coated reversed-phase packings with controlled hydrophobic properties.  II.  Effect on selectivity of peptide separations.  J. Chromatography  599:  77-85 (1992).
  9. Mant, C.T., T.W.L. Burke, A.J. Mendonca and R.S. Hodges.  Preparative reversed-phase sample displacement chromatography of peptides.  Proceedings of the 9th International Symposium on Preparative and Industrial Chromatography (1992) p.274-279.
  10. Hanson, M., K.K. Unger, C.T. Mant and R.S. Hodges.  Polymer-coated reversed-phase packings with controlled hydrophobic properties.  I.  Effect on the selectivity of protein separations.  J. Chromatography  599: 65-75 (1992).
  11. Zhu, B.-Y., C.T. Mant and R.S. Hodges.  Mixed-mode hydrophilic and ionic interaction chromatography rivals reversed-phase chromatography for the separation of peptides.  J. Chromatography  594: 75-86 (1992).
  12. Mant, C.T., N.E. Zhou and R.S. Hodges.  Amino acids and peptides.  In "Chromatography, 5th Edition Part B:  Applications (Ed. E. Heftmann).  Journal of Chromatography Library Volume 51B, Elsevier Science Publishers B.V., Amsterdam, The Netherlands, (1992) Chapter 13, pp. B75-B150.
  13. Zhu, B.-Y., C.T. Mant and R.S. Hodges.  Hydrophilic-interaction chromatography of peptides on hydrophilic and strong-cation-exchange columns.  Journal of Chromatogr. 548: 13-24 (1991).
  14. Hodges, R.S., T.W.L. Burke and C.T. Mant.  Multi-column reversed-phase sample displacement chromatography of peptides.  Journal of Chromatogr.548: 267-280 (1991).
  15. Zhou, N.E., C.T. Mant, J.J. Kirkland and R.S. Hodges.  Comparison of silica-based cyanopropyl- and octyl- reversed-phase packings for the separation of peptides and proteins.  Journal of Chromatogr. 548: 179-193  (1991).
  16. Thornton, S., E. San Fabian, S. Fraga, J.M.R. Parker and R.S. Hodges.  Prediction of protein secondary structures using a combined method based on the recognition, Lim and Garnier-Osguthorpe-Robson algorithms.  J. Mol. Structure (Theochem)., 232: 321-336 (1991).
  17. Hodges, R.S. and C.T. Mant.  Properties of peptides/proteins and practical implications.    In "High Performance Liquid Chromatography of Peptides and Proteins: Separation, Analysis and Conformation" (C.T. Mant and R.S. Hodges, eds.) CRC Press, Inc., (1991) pp. 3-9.
  18. Mant, C.T. and R.S. Hodges.  HPLC terminology:  Practical and theoretical.    In "High Performance Liquid Chromatography of Peptides and Proteins: Separation, Analysis and Conformation" (C.T. Mant and R.S. Hodges, eds.) CRC Press, Inc., (1991) pp. 69-94.
  19. Mant, C.T. and R.S. Hodges.  The use of peptide standards to monitor non-ideal behavior due to underivatized silanols in reversed-phase chromatography.    In "High Performance Liquid Chromatography of Peptides and Proteins: Separation, Analysis and Conformation" (C.T. Mant and R.S. Hodges, eds.) CRC Press, Inc., (1991) pp. 297-305
  20. Cachia, P.J. and R.S. Hodges.  Separation of protein isoforms: An ion-exchange HPLC separation of bovine and cardiac troponin complexes.  In "High Performance Liquid Chromatography of Peptides and Proteins: Separation, Analysis and Conformation" (C.T. Mant and R.S. Hodges, eds.) CRC Press, Inc., (1991) 245-253.
  21. Parker, J.M.R. and R.S. Hodges.  HPLC hydrophobicity parameters: Prediction of surface and interior regions in proteins.  In "High Performance Liquid Chromatography of Peptides and Proteins: Separation, Analysis and Conformation" (C.T. Mant and R.S. Hodges, eds.) CRC Press, Inc., (1991) pp. 737-749.
  22. Hodges, R.S. and C.T. Mant.  Standard chromatographic conditions for size-exclusion, ion-exchange, reversed-phase, and hydrophobic interaction chromatography. In "High Performance Liquid Chromatography of Peptides and Proteins: Separation, Analysis and Conformation" (C.T. Mant and R.S. Hodges, eds.) CRC Press, Inc., (1991) pp. 11-22.
  23. Burke, T.W.L., C.T. Mant and R.S. Hodges.  The effect of varying flow-rate, gradient rate and detection wavelength on peptide elution profiles in reversed-phase chromatography.  In "High Performance Liquid Chromatography of Peptides and Proteins: Separation, Analysis and Conformation" (C.T. Mant and R.S. Hodges, eds.) CRC Press, Inc., (1991) pp. 307-317.
  24. Mant, C.T. and R.S. Hodges.  Effects of HPLC solvents and hydrophobic matrices on denaturation of proteins.  In "High Performance Liquid Chromatography of Peptides and Proteins: Separation, Analysis and Conformation" (C.T. Mant and R.S. Hodges, eds.) CRC Press, Inc., (1991) pp. 437-450.
  25. Van Eyk, J.E., C.T. Mant and R.S. Hodges.  High-performance affinity chromatography of peptides and proteins.  In "High Performance Liquid Chromatography of Peptides and Proteins: Separation, Analysis and Conformation" (C.T. Mant and R.S. Hodges, eds.) CRC Press, Inc., (1991) pp. 479-491.
  26. Mant, C.T. and R.S. Hodges.  Mobile-phase preparation and column maintenance.  In "High Performance Liquid Chromatography of Peptides and Proteins: Separation, Analysis and Conformation" (C.T. Mant and R.S. Hodges, eds.) CRC Press, Inc., (1991) pp. 37-45.
  27. Burke, T.W.L., C.T. Mant and R.S. Hodges.  Comparison of peptide resolution on conventional, narrow bore and microbore reversed-phase columns.  In "High Performance Liquid Chromatography of Peptides and Proteins: Separation, Analysis and Conformation" (C.T. Mant and R.S. Hodges, eds.) CRC Press, Inc., (1991) pp. 679-686.
  28. Mant, C.T. and R.S. Hodges.  Development and application of a computer simulation program for method development and teaching in HPLC:  ProDigest-LC.  In "High Performance Liquid Chromatography of Peptides and Proteins: Separation, Analysis and Conformation" (C.T. Mant and R.S. Hodges, eds.) CRC Press, Inc., (1991) pp. 705-723.
  29. Hodges, R.S., Burke, T.W.L., C.T. Mant and S.-M. Ngai.  Preparative reversed-phase gradient elution chromatography on analytical columns.    In "High Performance Liquid Chromatography of Peptides and Proteins: Separation, Analysis and Conformation" (C.T. Mant and R.S. Hodges, eds.) CRC Press, Inc., (1991) pp. 773-782.
  30. Lee, K.K., J.A. Black and R.S. Hodges.  Separation of intrachain disulfide bridged peptides from their reduced forms by reversed-phase chromatography.  In "High Performance Liquid Chromatography of Peptides and Proteins: Separation, Analysis and Conformation" (C.T. Mant and R.S. Hodges, eds.) CRC Press, Inc., (1991) pp. 389-398.
  31. Mant, C.T. and R.S. Hodges.  Requirement for peptide standards to monitor ideal and non-ideal behavior in size-exclusion chromatography.  In "High Performance Liquid Chromatography of Peptides and Proteins: Separation, Analysis and Conformation" (C.T. Mant and R.S. Hodges, eds.) CRC Press, Inc., (1991)pp. 125-134 .
  32. Mant, C.T. and R.S. Hodges.  The use of peptide standards for monitoring ideal and non-ideal behavior in cation-exchange chromatography.  In "High Performance Liquid Chromatography of Peptides and Proteins: Separation, Analysis and Conformation" (C.T. Mant and R.S. Hodges, eds.) CRC Press, Inc., (1991) pp. 171-185.
  33. Mant, C.T. and R.S. Hodges.  Requirement for peptide standards to monitor column performance and the effect of column dimensions, organic modifiers and temperature in reversed-phase chromatography.  In "High Performance Liquid Chromatography of Peptides and Proteins: Separation, Analysis and Conformation" (C.T. Mant and R.S. Hodges, eds.) CRC Press, Inc., (1991) pp. 289-295.
  34. Mant, C.T. and R.S. Hodges.  The effects of anionic ion-pairing reagents on peptide retention in reversed-phase chromatography.  In "High Performance Liquid Chromatography of Peptides and Proteins: Separation, Analysis and Conformation" (C.T. Mant and R.S. Hodges, eds.) CRC Press, Inc., (1991) pp. 327-341.
  35. Mant, C.T. and R.S. Hodges.  On-line derivatization of silica supports for regeneration of reversed-phase columns.  In "High Performance Liquid Chromatography of Peptides and Proteins: Separation, Analysis and Conformation" (C.T. Mant and R.S. Hodges, eds.) CRC Press, Inc., (1991) pp. 57-65.
  36. Black, J.A. and R.S. Hodges.  Peak Identification in HPLC of peptides using spectral analysis and second order spectroscopy of aromatic amino acid residues.  In "High Performance Liquid Chromatography of Peptides and Proteins: Separation, Analysis and Conformation" (C.T. Mant and R.S. Hodges, eds.) CRC Press, Inc., (1991) pp. 563-570.
  37. Zhou, N.E., P.D. Semchuk, C.M. Kay and R.S. Hodges.  The effect of hydrophobic residue distribution in a-helical peptides on peptide retention behavior in reversed-phase HPLC.  In "High Performance Liquid Chromatography of Peptides and Proteins: Separation, Analysis and Conformation" (C.T. Mant and R.S. Hodges, eds.) CRC Press, Inc., (1991) pp. 643-658.
  38. Burke, T.W.L., J.A. Black, C.T. Mant and R.S. Hodges.  Preparative reversed-phase shallow gradient approach to the purification of closely related peptide analogs on analytical instrumentation.  In "High Performance Liquid Chromatography of Peptides and Proteins: Separation, Analysis and Conformation" (C.T. Mant and R.S. Hodges, eds.) CRC Press, Inc., (1991) pp. 783-791.
  39. Mant, C.T. and R.S. Hodges. Preparative reversed-phase sample displacement chromatography of synthetic peptides.  In "High Performance Liquid Chromatography of Peptides and Proteins: Separation, Analysis and Conformation" (C.T. Mant and R.S. Hodges, eds.) CRC Press, Inc., (1991) pp. 793-807.
  40. Mant, C.T., T.W.L. Burke, N.E. Zhou, J.M.R. Parker and R.S. Hodges.  Reversed-phase chromatographic method development for peptide separations using a computer simulation program:  ProDigest LC.  In "Computer-Assisted Method Development for High-Performance Liquid Chromatography" (J.L. Glajch and L.R. Snyder, Eds.) Elsevier (1990) pp. 365-382. (reprinted from J. Chromatogr. 485 (1989) 365-382).
  41. Thornton, S., E. San Fabian, S. Fraga, J.M.R. Parker and R.S. Hodges.  Theoretical prediction of secondary structures of proteins using recognition factors.  Journal of Molecular Structure  226: 87-97 (1990).
  42. Mant, C.T. and R.S. Hodges.  Optimization and prediction of peptide retention behavior in reversed-phase chromatography.  In "HPLC of proteins, peptides and polynucleotides:  Contemporary topics and applications" (M.T.W. Hearn, editor). VCH Publishers, Inc., U.S.A., 277-305 (1991).
  43. Zhou, N.E., C.T. Mant and R.S. Hodges. Effect of preferred binding domains on peptide retention behavior in reversed-phase chromatography: Amphipathic a-Helices.  Peptide Research  3: 8-20 (1990).  Reprinted in Biochromatography 5: 127-139 (1990).
  44. Mant, C.T. and R.S. Hodges. HPLC of Peptides. In "HPLC of biological macromolecules: Methods and applications" (K. Gooding and F. Regnier, Eds.) Marcel Dekker, Inc., New York, N.Y. (1990) pp. 301-332.

1985-1989
  1. Mant, C. T., T.W.L. Burke, N.E. Zhou, J.M.R. Parker and R.S. Hodges.  Reversed-phase chromatographic method development for peptide separations using a computer simulation program: ProDigest-LC.  J. Chromatogr. 485: 365-382 (1989).
  2. Mant, C.T. and R.S. Hodges.  Optimization of peptide separations in high performance liquid chromatography. J. Liquid Chromatogr. 12: 139-172 (1989).
  3. Mant, C.T., N.E. Zhou and R.S. Hodges.  Correlation of protein retention times in reversed-phase chromatography with polypeptide chain length and hydrophobicity.  J. Chromatography  476:363-375 (1989).
  4. Burke, T.W.L., C.T. Mant, J.A. Black and R.S. Hodges.  Strong cation-exchange HPLC of peptides:  Effect of non-specific hydrophobic interactions and linearization of peptide retention behavior.  J. Chromatography  476: 377-389 (1989).
  5. Hodges, R.S., J.M.R. Parker, C.T. Mant and R.R. Sharma.  Computer simulation of HPLC separations of peptide and protein digests for development of size-exclusion, ion-exchange and reversed-phase chromatographic methods.  J.  Chromatogr. 458: 147-167 (1988).
  6. Mant, C.T., T.W.L. Burke, J.A. Black and R.S. Hodges. The effect of peptide chain length on peptide retention behavior in  reversed-phase chromatography. J. Chromatogr. 458: 193-205 (1988).
  7. Fraga, S., R.S. Hodges, J.M.R. Parker, E. San-Fabian and A.V. Bunge. Computer modelling of protein structures. J. Molecular Structure  (Theochem) 166: 129-134 (1988).
  8. Burke, T.W.L., C.T. Mant and R.S. Hodges.  A novel approach to reversed-phase preparative high-performance liquid chromatography of peptides.  J. Liquid Chromatography 11: 1229-1247 (1988).
  9. Hearn, M.T.W., M.I. Aguilar, C.T. Mant and R.S. Hodges. Evaluation of the use of hydrophobicity coefficients for the prediction of peptide elution profiles. J. Chromatogr438 197-210 (1988).
  10. Hodges, R.S., T.W.L. Burke and C.T. Mant. Preparative purification of peptides by  reversed-phase chromatography: Sample displacement mode versus gradient elution mode. J. Chromatogr. 444: 349-362 (1988).
  11. Parker, J.M.R., C.T. Mant and R.S. Hodges. A practical approach to the preparative purification of peptides using analytical instrumentation with analytical and semipreparative columns. Chromatographia  24: 832-838 (1987).
  12. Mant, C.T., T.W.L. Burke and R.S. Hodges. Optimization of peptide separations in reversed-phase HPLC: Isocratic versus gradient elution.  Chromatographia  24: 565-572 (1987).
  13. Mant, C.T. and R.S. Hodges. Monitoring free silanols on reversed-phase supports with peptide standards. Chromatographia  24: 805-814 (1987).
  14. Mant, C.T. and R.S. Hodges. On-line derivatization of silica columns for regeneration and preparation of reversed-phase supports. J. Chromatogr. 409: 155-173 (1987).
  15. Guo, D., C.T. Mant and R.S. Hodges. Effects of ion-pairing reagents on the prediction of peptide retention in reversed-phase high-performance liquid chromatography. J. Chromatogr. 386:  205-222 (1987).
  16. Mant, C.T., J.M.R. Parker and R.S. Hodges. Size-exclusion HPLC of peptides: Requirement for peptide standards to monitor non-ideal behavior. J. Chromatogr. 397: 99-112 (1987).
  17. Mant, C.T., J.M.R. Parker and R.S. Hodges. On-line derivatization to restore reversed-phase column performance in peptide separations. LC.GC Magazine of Liquid and Gas Chromatography 4: 1004-1009 (1986).
  18. Mant, C.T. and R.S. Hodges. Requirement for peptide standards in reversed-phase high performance liquid chromatography. LC Magazine, Liquid Chromatography  and HPLC 4: 250-254 (1986).
  19. Parker, J.M.R., D. Guo and R.S. Hodges. A new hydrophilicity scale derived from HPLC peptide retention data: Correlation of predicted surface residues with antigenicity and X-ray derived accessible sites. Biochemistry  25: 5425-5432 (1986).
  20. Guo, D., C.T. Mant, A.K. Taneja, J.M.R. Parker and R.S. Hodges. Prediction of peptide retention times in reversed-phase high-performance liquid chromatography. I. Determination of retention coefficients of amino acid residues using model synthetic peptides. J. Chromatogr.  359:  499-518 (1986).
  21. Guo, D., C.T. Mant, A.K. Taneja and R.S. Hodges. Prediction of peptide retention times in reversed-phase high-performance liquid chromatography. II. Correlation of observed and predicted peptide retention times and factors influencing retention times of peptides. J. Chromatogr. 359: 519-532 (1986).
  22. Mant, C.T. and R.S. Hodges. A general method for the separation of cyanogen bromide  digests  of proteins by high performance liquid chromatography: Rabbit skeletal troponin I. J.Chromatogr. 326: 349-356 (1985).
  23. Ingraham, R.H., S.Y.M. Lau, A.K. Taneja and R.S. Hodges. Denaturation and the effects of temperature on hydrophobic interaction and reversed-phase high performance liquid chromatography of proteins: Bio-Gel TSK-Phenyl-5-PW support. J. Chromatogr. 327: 77-92 (1985).
  24. Mant, C.T. and R.S. Hodges. Separation of peptides by strong cation-exchange high performance liquid chromatography. J. Chromatogr. 327: 147-155 (1985).
  25. Cachia, P.J., J. Van Eyk, W.D. McCubbin, C.M. Kay and R.S. Hodges. High performance ion-exchange liquid chromatographic purification of bovine cardiac and rabbit skeletal muscle troponin subunits. J. Chromatogr. 343: 315-328 (1985).

1980-1984
  1. Taneja, A.K., S.Y.M. Lau and R.S. Hodges. Separation of hydrophobic peptide polymers by size-exclusion and reversed-phase high performance liquid chromatography. J. Chromatogr. 317: 1-10 (1984).
  2. Lau, S.Y.M., A.K. Taneja and R.S. Hodges. Effects of HPLC solvents and hydrophobic supports on the secondary and quaternary structure of a model protein: Reversed-phase and size-exclusion high performance liquid chromatography. J. Chromatogr. 317: 129-140 (1984).
  3. Cachia, P.J., J. Van Eyk, P.C.S. Chong, A. Taneja and R.S. Hodges. Separation of basic peptides by cation-exchange high pressure liquid chromatography.  J. Chrom. 266: 651-659 (1983).
  4. Hofmann, T. and R.S. Hodges. A new chromophoric substrate for penicillopepsin and other fungal aspartyl proteinases.  Biochem. J. 203: 603-610 (1982).
  5. Chong, P.C.S. and R.S. Hodges. A new heterobifunctional crosslinking reagent for the study of biological interactions between proteins. I. Design, synthesis and characterization.  J. Biol. Chem. 256:  5064-5070 (1981).
  6. Chong, P.C.S. and R.S. Hodges. A new heterobifunctional crosslinking reagent for the study of biological interactions between proteins.  II. Application to the troponin C-troponin I interaction.  J. Biol. Chem. 256: 5071-5076 (1981).
1975-1979
  1. Tjoeng, F.-S., E.K. Tong and R.S. Hodges. Liquid-phase synthesis of protected peptides on the new 3-nitro-4-bromomethylbenzoyl polyethylene glycol support.  J. Org. Chem. 43: 4190-4194 (1978).
  2. Tjoeng, F.-S. and R.S. Hodges. Cleavage of protected amino acids and peptides from the new o-nitrobenzoyl polyethylene glycol support by catalytic hydrogenolysis.  Tetrahedron Letters  15: 1273-1276 (1979).
  3. Mitchell, A.R., B.W. Erickson, M.N. Ryabtsev, R.S. Hodges and R.B. Merrifield. Boc-amino-acyl-4-(oxymethyl)phenyl-acetamidomethyl-resin, a more acid-resistant support for solid-phase peptide synthesis.  J. Am. Chem. Soc. 98: 7357-7362  (1976).
  4. Tjoeng, F.-S., W. Staines, S.A. St.-Pierre and R.S. Hodges. Liquid-phase method for peptide synthesis utilizing photolytic cleavage from a new o-nitrobenzoyl polyethylene glycol support.  Biochim. Biophys. Acta  (Protein Structure)  490: 489-496 (1977).
  5. Hodges, R.S. and R.B. Merrifield. Monitoring of solid-phase peptide synthesis by an auto-mated spectrophotometric picrate method.  Anal. Biochem.  65: 241-272 (1975).

1970-1974
  1. Hodges, R.S. and R.B. Merrifield. Synthesis of O-methyl-L-serine and Na-tert-butyloxy-carbonyl-0-methyl-L-serine.  J. Org. Chem. 39: 1870-1872 (1974).

Proceedings Publications

2015-2019
NA

2010-2014
  1. Cepeniene, D., R. Irvin, R.S. Hodges and L. Gera.  Selective labeling of lysine-containing biologically active peptides at the N-terminus with alexa fluor dye.  In Peptides: Building Bridges (M. Lebl, Ed.), Proceedings of the 22nd American Peptide Symposium, San Diego, CA, pp. 76-77 (2011).

2005-2009
  1. Kovacs, J.M., C.T. Mant and R.S. Hodges.  Determination of Intrinsic Hydrophilicity /Hydrophobicity Coefficients of Amino Acid Side-Chains using Synthetic Model Peptides.  In Understanding Biology Using Peptides:  Proceedings of the 19th American Peptide Symposium.  San Diego, CA (2005) (S.E. Blondelle, Ed.)  Springer Science, New York, NY  pp 679-682 (2006).

2000-2004
  1. Mehok, A.R., C.T. Mant, B. Tripet and R.S. Hodges.  Isocratic reversed-phase chromatography separation and purification of peptides.  In Peptide Revolution:  Genomics, Proteomics and Therapeutics, Proceedings of the Eighteenth American Peptide Symposium Boston, MA (2003) (M. Chorev and T. K. Sawyer, Eds.) American Peptide Society pp. 145-146 (2004).
  2. Popa, T.V., C.T. Mant and R.S. Hodges.  Comparison of effect of anionic ion-pairing reagents on capillary electrophoresis and reversed-phase chromatography of cationic random coil peptides. In Peptide Revolution:  Genomics, Proteomics and Therapeutics, Proceedings of the Eighteenth American Peptide Symposium Boston, MA (2003) (M. Chorev and T. K. Sawyer, Eds.) American Peptide Society pp. 123-124  (2004).
  3. Lee, D.L., C.T. Mant and R.S. Hodges.  Monitoring self-association of small amphipathic molecules by temperature profiling in reversed-phase chromatography. In Peptide Revolution:  Genomics, Proteomics and Therapeutics, Proceedings of the Eighteenth American Peptide Symposium Boston, MA (2003) (M. Chorev and T. K. Sawyer, Eds.) American Peptide Society pp. 149-150 (2004).
  4. Chen, Y. and R.S. Hodges. Effect of secondary structure on selectivity of reversed-phase chromatography for peptide separations at varying temperatures. In Peptide Revolution:  Genomics, Proteomics and Therapeutics, Proceedings of the Eighteenth American Peptide Symposium Boston, MA (2003) (M. Chorev and T. K. Sawyer, Eds.) American Peptide Society pp.  151-152) (2004).
  5. Merrifield, B., G. Barany, C.M. Deber, M. Goodman, R.S. Hodges, V.J. Hruby, T.W. Muir, R. Offord, A.F. Spatola, D.F. Veber and G.B. Fields. Perspectives for the new peptide millennium. InPeptides for the New Millennium”, Proceedings of the Sixteenth American Peptide Symposium (G.B. Fields, J.P. Tam and G. Barany, Eds.), Kluwer Academic Publishers, pp. 797-804 (2000).

1995-1999
  1. Mant, C.T. and R.S. Hodges.  Reversed-phase chromatography as a mimic of ligand-receptor interactions.  In:   Peptides:  Chemistry, Structure and Biology, Proceedings of the Fourteenth American Peptide Symposium (P. Kaumaya and R.S. Hodges, Eds.) Mayflower Scientific Ltd., England, pp. 46-47 (1996).
  2. Semchuk, P.D., O.D. Monera, L.H. Kondejewski, C. Gannon, L. Daniels, I. Wilson and R.S. Hodges.  Preferential disulfide-bridge formation for hetero-dimers by derivatization with 2,2'-dithiodipyridine.  In:   Peptides:  Chemistry, Structure and Biology, Proceedings of the Fourteenth American Peptide Symposium (P. Kaumaya and R.S. Hodges, Eds.) Mayflower Scientific Ltd., England, pp. 73-74 (1996).

1990-1994
  1. Wang, J., R.S. Hodges and B.D. Sykes.  Elucidation of multiple conformations for flexible peptides from average NOE data:  Application to desmopressin.  In:   Peptides:  Chemistry, Structure and Biology, Proceedings of the Thirteenth American Peptide Symposium (R.S. Hodges and J.A. Smith, Eds.), Escom Science Publishers, Leiden, The Netherlands, pp.914-917 (1994).
  2. Zhu, B.-Y., C.T. Mant and R.S. Hodges.  Mixed-mode hydrophilic and ionic interaction chromatography rivals reversed-phase chromatography for the separation of peptides. In "Peptides: Chemistry and Biology", Proceedings of the 12th American Peptide Symposium (J. Smith and J.E. Rivier, Eds.) Escom Science Publishers, The Netherlands (1992) 546-548.
  3. Lee, K.K., J.A. Black and R.S. Hodges.  Air oxidation of peptides and separation of their reduced and intrachain disulfide bridged forms by RPHPLC.  In "Peptides:  Chemistry, Structure and Biology".  Proceedings of the Eleventh American Peptide Symposium (J.E. Rivier and G.R. Marshall, Eds.), Escom Science Publishers, The Netherlands (1990) pp. 999-1002.

1985-1989
  1. Hodges, R.S., T.W.L. Burke and C.T. Mant.  A novel approach to the purification of peptides by reversed-phase  HPLC: Sample displacement chromatography.  In "Peptides: Chemistry and Biology - Proceedings of the Tenth American Peptide Symposium (G. R. Marshall, Editor) Escom Science Publishers,  Leiden, The Netherlands, pp. 226-228 (1988).
  2. Guo, D., C.T. Mant, J.M.R. Parker and R.S. Hodges. Hydrophilicity parameters in peptides.1. Prediction of peptide retention in reversed-phase HPLC (RPC). 2. Prediction of hydrophilic regions on the surface of proteins. In  "Peptides: Structure and Function-Proceedings of the Ninth American Peptide Symposium" (C.M. Deber, V.J. Hruby and K.D. Kopple, eds.) Pierce Chemical Co. pp. 23-26 (1985).​
​​​​
2015-2019

  1. Avdieiev, S.S., L. Gera, R. Hodges and V.V. Dmytrenke.  Glioma-associated protein CHI3L2 suppresses cells viability and induces G1/S transition arrest.  Biopolymers and Cell, 31: 316-320 (2015).
  2. Avidieve, S., L. Gera, D. Havryl, R.S. Hodges, R. Lesyk, V. Ribrag, Y. Vassetzky, V. Kavsan.  Development of effective drug combinations for glioblastoma and mantle cell lymphoma treatment.  In Biopolymers Cell, Special issue, 31: 20-22 (2015).


2010-2014

  1. Avdieiev, S., Gera, L., Havrylyuk, D., Hodges, R.S., Lesyk, R., Ribrag, V., Vassetzky, Y., Kavsan, V. (2014). Bradykinin antagonists and thiazolidinone derivatives as new potential anti-cancer compounds. Biorg.Med. Chem.  22:3815-3823.  http://dx.doi.org/10.1016/j.bmc.2014.06.046.
  2. Avdieiev, S.S., Gera, L., Hodges, R., Vassetzky, Y.S., Kavsan, V.M. (2014). Growth suppression activity of bradykinin antagonists in glioma cells. Biopolym. Cell 30(1), 77-79. DOI: http://dx.doi.org/10.7124/bc.000883.
  3. Baumgartner, H.K., N. Beeman, R.S. Hodges and M.C. Neville.  A D-peptide analog of the second extracellular loop of claudin-3 and -4 leads to mis-localized claudin and cellular apoptosis in mammary epithelial cells.  Chem. Biol. & Drug Design 77: 124-136 (2011). (Journal Cover Figure)  PMC3080100 PMID21266016


Proceedings Publications

2015-2019

  1. Gera, L., J. Tentler, S.G. Eckhardt, Z. Jiang, A. D’Alessandro and R.S. Hodges. Development of novel broad spectrum anticancer small molecule peptidomimetics with nanomolar activity.  In Enabling Peptide Research from Basic Research to Drug Discovery, Proceedings of the 24th American Peptide Symposium, Orlando, FL (V. Srivastava, A. Yudin and M. Lebl, editors) pp. 241-244 (2015) Published by the American Peptide Society and Propt Scientific Publishing, 2015.


2010-2014
NA

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