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University of Colorado Department of Biochemistry and Molecular Genetics

Biochemistry and Molecular Genetics
 

Publications


Rozhok, A., and DeGregori, J. The evolution of lifespan and age-dependent cancer risk. Trends in Cancer, in press.

Casas-Selves, M., and DeGregori, J. (2011). How cancer shapes evolution, and how evolution shapes cancer. Evolution: Education and Outreach, 4:624–634. Publication PDF​


 

Aging-Associated Changes in Hematopoiesis and Leukemogenesis: What's the Connection?

Henry CJ, Marusyk A, Degregori

J.Aging (Albany NY). 2011 Jun;3(6):643-56. Publication PDF

 

Evolved tumor suppression: why are we so good at not getting cancer?

DeGregori

J. Cancer Res. 2011 Jun 1;71(11):3739-44. Epub 2011 May 24.

 

A new role for E2F1 in DNA repair: All for the greater good. 

Degregori J.

Cell Cycle. 2011 Jun 1;10(11):1719-8. Epub 2011 Jun 1.

 

Relative fitness of hematopoietic progenitors influences leukemia progression. 

Porter CC, Baturin D, Choudhary R, DeGregori. 

J. Leukemia. 2011 May;25(5):891-5. Epub 2011 Feb 18. No abstract available

 

Declining lymphoid progenitor fitness promotes aging-associated leukemogenesis.

Henry CJ, Marusyk A, Zaberezhnyy V, Adane B, Degregori J.

Proc Natl Acad Sci U S A. 2010 Nov 22. [Epub ahead of print] Publication PDF

 

Ionizing radiation and hematopoietic malignancies: altering the adaptive landscape.

Fleenor CJ, Marusyk A, DeGregori J.

Cell Cycle. 2010 Aug 1;9(15):3005-11. Epub 2010 Aug 7. Publication PDF

 

Mutation-specific control of BCR-ABL T315I positive leukemia with a recombinant yeast-based therapeutic vaccine in a murine model.

Bui MR, Hodson V, King T, Leopold D, Dai S, Fiolkoski V, Oakes S, Duke R, Apelian D, Franzusoff A, DeGregori J.

Vaccine. 2010 Aug 23;28(37):6028-35. Epub 2010 Jul 7.

 

Wnt/Ca2+/NFAT signaling maintains survival of Ph+ leukemia cells upon inhibition of Bcr-Abl.

Gregory MA, Phang TL, Neviani P, Alvarez-Calderon F, Eide CA, O'Hare T, Zaberezhnyy V, Williams RT, Druker BJ, Perrotti D, Degregori J.

Cancer Cell. 2010 Jul 13;18(1):74-87. Publication PDF

 

Irradiation selects for p53-deficient hematopoietic progenitors.

Marusyk A, Porter CC, Zaberezhnyy V, DeGregori J.

PLoS Biol. 2010 Mar 2;8(3):e1000324. Publication PDF​

 

Irradiation alters selection for oncogenic mutations in hematopoietic progenitors.

Marusyk A, Casás-Selves M, Henry CJ, Zaberezhnyy V, Klawitter J, Christians U, DeGregori J.

Cancer Res. 2009 Sep 15;69(18):7262-9. Epub 2009 Sep 8.

 

Interfering RNA-mediated purine analog resistance for in vitro and in vivo cell selection.

Porter CC, DeGregori J.

Blood. 2008 Dec 1;112(12):4466-74. Epub 2008 Jun 27.

 

Declining cellular fitness with age promotes cancer initiation by selecting for adaptive oncogenic mutations.

Marusyk A, DeGregori J.

Biochim Biophys Acta. 2008 Jan;1785(1):1-11. Epub 2007 Oct 12. Review.

 

Replicational stress selects for p53 mutation.

Marusyk A, DeGregori J.

Cell Cycle. 2007 Sep 1;6(17):2148-51. Epub 2007 Jul 10.

 

p53 mediates senescence-like arrest induced by chronic replicational stress.

Marusyk A, Wheeler LJ, Mathews CK, DeGregori J.

Mol Cell Biol. 2007 Aug;27(15):5336-51. Epub 2007 May 21.

 

Impaired DNA replication within progenitor cell pools promotes leukemogenesis.

Bilousova G, Marusyk A, Porter CC, Cardiff RD, DeGregori J.

PLoS Biol. 2005 Dec;3(12):e401. Epub 2005 Nov 15.

 

Search PubMed for the full list of publications