lab studies the role of autophagy in cell death as it relates to cancer
development, progression and treatment. Autophagy is the main cellular
recycling method that delivers cellular material to the lysosome and is
intimately connected to cell death.
Research Project Areas
• Why do
some cancer cells rely on autophagy and does this reliance create a therapeutic
window allowing autophagy inhibitors to be a useful cancer treatment?
• How does
autophagy control programmed cell death mechanisms by apoptosis and necroptosis?
• How does
autophagy affect the efficacy of
Autophagy regulates tumor cell response
to chemotherapy by degrading the transcription factor FOXO3a to control
apoptosis through the PUMA gene.
Cell Reports, 2014
Autophagy-dependent and –independent
cancer. Selection of a custom shRNA library targeting ~130 autophagy regulators
separates breast cancer cells on the basis of their autophagy-dependence. Cancer
Autophagy controls switching between necroptosis
and apoptosis by regulating necroptosome complexes on
autophagosomal structures detected by immune electron microscopy (A) and
proximity ligation assay (B). Developmental Cell,