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Andrew Thorburn, D Phil

Professor and Chairman


Contact Information:

University of Colorado Denver
Department of Pharmacology
Mail Stop 8303, RC1-South
12801 East 17th Ave
Aurora CO 80045

Phone: (303) 724-3290
Fax: (303) 724-3663
E-mail: andrew.thorburn@ucdenver.edu
Office: RC1-South, L18-6104

curriculum vitae

Affiliated Programs

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Our lab studies the role of autophagy in cell death as it relates to cancer development, progression and treatment. Autophagy is the main cellular recycling method that delivers cellular material to the lysosome and is intimately connected to cell death.

Research Project Areas

•  Why do some cancer cells rely on autophagy and does this reliance create a therapeutic window allowing autophagy inhibitors to be a useful cancer treatment?

•  How does autophagy control programmed cell death mechanisms by apoptosis and necroptosis?

•  How does autophagy affect the efficacy of anti-cancer drugs?


Autophagy regulates tumor cell response to chemotherapy by degrading the transcription factor FOXO3a to control apoptosis throug 

Autophagy regulates tumor cell response to chemotherapy by degrading the transcription factor FOXO3a to control apoptosis through the PUMA gene.

Cell Reports, 2014 &

Developmental Cell, 2018







 
 

Autophagy-dependent and –independent cancer. Selection of a custom shRNA library targeting ~130 autophagy regulators separates breast cancer cells on the basis of their autophagy-dependence. Cancer Research, 2014

 





 

Autophagy controls switching between necroptosis and apoptosis by regulating necroptosome complexes on autophagosomal structures detected by immune electron microscopy (A) and proximity ligation assay (B). Developmental Cell, 2016.

 




Current Lab Members 

 Results From Personnel : Selected site and subsites
First NameLast NameMiddle InitialDegreePosition
BrentFitzwalterEBSGraduate Student
MichaelMorganJ.PhDInstructor
KeisukeSato PhDVisiting Professor
JacquelineThorburnS.BTechSenior Professional Research Assistant
ChristinaTowers PhDPostdoctoral Fellow
  

Past Trainees 

 Results From Personnel : Selected site and subsites
First NameLast NameMiddle InitialDegreePosition
SureshbabuAngara PhDPostdoctoral Fellow
MelanieBadtkeM.PhDGraduate Student
LauraBenderM.BSGraduate Student
LianghuaBin PhDPostdoctoral Fellow
PeterClarkE.MDPostdoctoral Fellow
GracielaGamezA.MSProfessional Research Assistant
TatianaGoncharov PhDPostdoctoral Fellow
JacobGump PhDPostdoctoral Fellow
WallaceHeltonR.PhDGraduate Student
JustinHoltW.BSGraduate Student
HenrickHoritaN.PhDGraduate Student
SeanKearnsM.PhDPostdoctoral Fellow
PaolaMaycotte PhDPostdoctoral Fellow
JerryMitchell MDPostdoctoral Fellow
FranklinMoore MD/PhDPostdoctoral Fellow
JeanMulcahy-Levy MDInstructor
BurinNuchniyom MDPostdoctoral Fellow
PatrickO'TooleSMSGraduate Student
AnuradhaRao PhDPostdoctoral Fellow
JennySamsonMBAGraduate Student
J. RobinsonSingleton MDPostdoctoral Fellow
LeahStaskiewicz BSFromer Professional Research Assistant
WesleyThacker MDPostdoctoral Fellow
LanceThomasR.BSGraduate Student
TohruYonekawa PhDPostdoctoral Fellow
ShadiZahedi MSProfessional Research Assistant
LianZhang MD/PhDPostdoctoral Fellow