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Fluorescence in situ Hybridization (FISH)

Fluorescence in situ hybridization (FISH) uses DNA probes specific for particular areas of the genome. It can detect losses and, in some cases, duplication of DNA at a locus.


FISH is performed to:

    • Enumerate chromosomes
    • Detect partial monosomy and triploidy
    • Diagnose specific microdeletion and microduplication syndromes
    • Detect acquired abnormalities for diagnostic/prognostic indications in certain types of cancer

FISH Testing at CGL


FISH for microdeletion/microduplication syndromes
FISH for gender determination
FISH for chromosome abnormalities common in pregnancy loss​
FISH for chromosome abnormalities in cancer
FISH for chimerism studies in bone marrow transplant patients