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Frances L. Meredith, PhD

Research Assistant Professor

​Department of Otolaryngology Research Division 

Dr. Meredith​ received her PhD from the University of Colorado and completed her postdoctoral fellowship in the Rennie Lab, Department of Otolaryngology. In February 2018, she was appointed Research Assistant Professor in the department.

Dr. Meredith’s research focuses on understanding the roles that ion channels play in vestibular functioning. She uses patch clamp electrophysiology to record from vestibular hair cells and the primary afferent neurons that contact them. Studies include identification of regional and developmental differences in calyceal potassium and sodium currents and action potential firing patterns. Current research focuses on the role of sodium channels at the type I hair cell and calyx synapse using immunohistochemistry and patch clamp techniques.
Dr. Meredith was awarded an institutional NIH T32 training grant (Basic Neuroscience Advanced Training) for her doctoral thesis work and subsequently received a 2 year NSBRI (NASA) First Award Post-doctoral Fellowship, a Hearing Health Foundation Fellowship, an American Hearing Health Foundation grant and an American Otological Society grant.​
Ø Li GQ, Meredith FL, Rennie KJ. Development of K+ and Na+ conductances in rodent postnatal semicircular canal type I hair cells. Am J Physiol Regul Integr Comp Physiol. 2010 298(2):R351-8.

Ø ​Dhawan R, Mann SE, Meredith FL, Rennie KJ. K+ currents in isolated vestibular afferent calyx terminals. J Assoc Res Otolaryngol. 2010 (3):463-76.

Ø Meredith FL, Li GQ, Rennie KJ. Postnatal expression of an apamin-sensitive K(Ca) current in vestibular calyx terminals. J Membr Biol. 2011 (2):81-91.

ØMeredith FL, Benke TA, Rennie KJ. Hyperpolarization-activated current (Ih) in vestibular calyx terminals: characterization and role in shaping postsynaptic events. J Assoc Res Otolaryngol. 2012 (6):745-58.

ØMann SE, Johnson M, Meredith FL, Rennie KJ. Inhibition of K+ currents in vestibular hair cells by gentamicin and neomycin. Audiology & neuro-otology. 2013; 18(5):317-26.

ØMeredith FL, Rennie KJ. Zonal variations in K+ currents in vestibular crista calyx terminals. J Neurophysiol. 2015 (1):264-76.

ØMeredith FL, Kirk ME and Rennie KJ. Kv1 channels and neural processing in vestibular afferents. Front. Syst. Neurosci. Frontiers in systems neuroscience. 2015; 9:85.

ØMeredith FL, Rennie KJ. Channeling your inner ear potassium: K+ channels in vestibular hair cells. Hearing Res. 2016; 338:40-51.

ØKirk ME, Meredith FL, Benke TA, Rennie KJ. AMPA receptor-mediated rapid EPSCs in vestibular calyx afferents. J Neurophysiol. 2017  Mar 15:jn.00394.2016. [Epub ahead of print]