Mayumi Fujita, M.D., Ph.D.
Associate Professor
Department of Dermatology
Phone: (303) 724-4045 (office), 303-724-4037 or 303-724-4046 (lab)
Fax: (303) 724-4048
EDUCATION/TRAINING |
Institution and location |
Degree |
Field of study |
Kyoto University Faculty of Medicine, Japan |
M.D. |
Medicine |
Kyoto University Faculty of Medicine, Japan |
Internship |
Medicine/Dermatology |
Kyoto University Faculty of Medicine, Japan |
Residency |
Dermatology |
Kyoto University Faculty of Medicine, Japan |
Ph.D. |
Immunology |
University of Colorado, Denver, CO |
Fellowship |
Tumor biology |
University of Washington, Seattle, WA |
Fellowship |
Skin biology |
University of Washington, Seattle, WA |
Internship |
Internal Medicine |
University of Washington, Seattle, WA |
Residency |
Dermatology |
EMPLOYMENT
1986 - 1990 Instructor in Dermatology, Kyoto University FOM, Kyoto, Japan
1990 - 1992 Medical Staff in Dermatology, Tenri Hospital, Nara, Japan
1992 - 1996 Assistant Professor of Dermatology, Kyoto University FOM, Kyoto, Japan
2002 - 2008 Assistant Professor of Dermatology, University of Colorado HSC, Aurora, CO
2002 - present Director of Psoriasis Clinic, University of Colorado Hospital, Aurora, CO
2008 - present Associate Professor of Dermatology, University of Colorado Denver, Aurora, CO
2010- present Dermatology physician, Department of Veterans Affairs Hospital, Denver, CO
HONORS
Sasagawa Research Award (1992-3, 1993-4), Dermatology Foundation Fellowship (1993-4, 1994-5), Women’s Dermatologic Society Mentorship award (2001), NIH Fellowship (5 T32 AR07019-25) (2001-2), AAD (American Association of Dermatology) Travel Award to European Dermatology Society Meeting (2001), NIH Award for NIH Dermatology Branch Resident Visit Day (2001), World Congress Education Fund Task Force Scholarship Award for International Investigative Dermatology 2003 (2003)
INVENTIONS AND PATENTS
WO/2008/069881 (International Application No. PCT/US2007/023386)
US2010/0248225 A1 (U.S. Patent Application No. 12/312,390)
WO/2009/085695 (International Application No. PCT/US2008/086830)
US20090169497 (U.S. Patent Application No. 12/335,110)
CLINICAL INTERESTS
Psoriasis, auto-immune disease, melanoma
RESEARCH INTERESTS
Melanoma biology, melanoma immunology, skin immunology, disease biomarker
OVERVIEW OF ONGOING RESEARCH
The main focus of our current research is: (1) to study biological roles of several inflammatory molecules (particularly IL-1, IL-37 and AAT) in the progression of human malignant melanoma, (2) to analyze inflammasome components in human melanoma cells, (3) to identify melanoma-related and host response-related biomarker profiling from blood of melanoma patients, (4) to identify and characterize melanoma stem cells from human melanoma cells and (5) to study biological roles of several inflammatory molecules in skin immunology. The experiments utilize in vitro methodologies (cellular and molecular biology, immunology, pathology) and in vivo animal study (xenotransplantation, direct in vivo xenograft and genetically-engineered mouse models).
SELECTED PUBLICATIONS (15 most recent papers out of 51 peer-reviewed ones)
1. Y Luo, S Robinson, J Fujita, L Siconolfi, J Magidson, CK Edwards, K Wassman, K Strom, DA Norris, D Bankaitis-Davis, WA Robinson, M Fujita: Transcriptome profiling of whole blood cells identifies PLEK2 and C1QB in human melanoma. Accepted for publication in PLoS ONE
2. R Prado, James D Jensen, M Okamoto, Y Luo, KD Lewis, M Fujita: Metastatic melanoma manifesting with purulent nodules composed of neutrophils and melanoma cells. Accepted for publication in European Journal of Dermatology
3. A Tanaka, James D Jensen, Renata Prado, H Riemann, YG Shellman, DA Norris, L Chin, C Yee, M Fujita: Whole recombinant yeast vaccine induces anti-tumor immunity and improves survival in a genetically engineered mouse model of melanoma. Gene Therapy 18, 2011 (in press).
4. A Anwar, DA Norris, M Fujita: Ubiquitin proteasomal pathway mediated degradation of p53 in melanoma. Arch Biochem Biophys 508:198-203, 2011
5. James D Jensen, Mayumi Fujita, and Robert P. Dellavalle. Validation of Psoriasis Clinical Severity and Outcome Measures: Searching for a Gold Standard. Arch Dermatol 147:95-98, 2011
6. R Prado, S Brice, S Fukuda, T Hashimoto, M Fujita: Paraneoplastic pemphigus herpetiformis with IgG antibodies to desmoglein 3 and without mucosal lesions. Arch Dermatol 147:67-71, 2011
7. X. Wang, M. Fujita (corresponding author), R. Prado, A. Tousson, H-C. Hsu, A. Schottelius, D.R. Kelly, P.A. Yang, Q. Wu, J. Chen, H. Xu, C.A. Elmets, J.D. Mountz, C.K.III Edwards: Visualizing CD4 T cell migration into inflamed skin and its inhibition by CCR4/CCR10 blockades using in vivo imaging model. Br J Dermatol 162: 487-96, 2010
8. J Strahan, JA Chorny, JL Cohen, M Fujita: Combined multifocal indeterminate cell histiocytosis and basal cell carcinoma. Arch Dermatol 146:346-7, 2010
9. M Okamoto, W Liu, Y Luo, A Tanaka, X Cai, DA Norris, CA Dinarello, M Fujita: Constitutively active inflammasome in human melanoma cells mediating autoinflammation via caspase-1 processing and secretion of interleukin-1b. J Biol Chem 285: 6477-88, 2010
10. J Strahan, M Fujita: Violaceous nodule on the knee. Arch Dermatol 145:715-720, 2009
11. LA Miller, NB Goldstein, WU Johannes, C Walton, M Fujita, DA Norris, YG Shellman: BH3 mimetic ABT-737 synergistically kills melanoma cells with a proteasome inhibitor. J Invest Dermatol 129: 964-971, 2009
12. NB Goldstein, WU Johannes, AV Fadeliya, M Green, M Fujita, DA Norris, YG Shellman: Active Nras and Braf inhibit anoikis by downregulating Bim expression in melanoma cells. J Invest Dermatol 129: 432-437, 2009
13. M Fujita, W High, S Asgari, C Lewis, R Gonzalez: Development of vitiligo during melanoma treatment with a novel survivin inhibitor: a case report and review of the literature. Int J of Dermatol 48: 426-430, 2009
14. ML Usui, JN Mansbridge, WG Carter, M Fujita, JE Olerud: Keratinocyte migration, proliferation and differentiation in chronic ulcers from patients with diabetes and normal wounds. J Histochem Cytochem 56:687-696, 2008
15. A Anwar, GU Mallikarjuna, S Brady, L Qamar, K Behbakht, YG Shellman, R Agarwal, DA Norris, L Horwitz, M Fujita: Photoprotective effects of bucillamine against UV-induced damage in a SKH-1 hairless mouse model. Photochemistry and Photobiology 84:477-483, 2008
OTHER PUBLICATIONS (non peer-reviewed)
9 proceedings (non peer-reviewed)
4 invited review articles (non peer-reviewed)
67 meeting abstracts published in journals
76 clinical/research papers in Japanese medical journals (in Japanese)
30 medical essays in Japanese Journal of Clinical Dermatology (in Japanese)