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Developmental Research Program


Developmental Research Program

Chair: Paul A. Bunn, Jr., MD
Committee
Anna E. Barón, PhD              Raphael Nemenoff, PhD
D. Ross Camidge, MD, PhD    Holly Wolf, PhD, MPH
Wilbur A. Franklin, MD           Kenneth Jones, PhD
Fred R. Hirsch, MD, PhD         Andrew M. Thorburn,PhD
Jeffrey Kern, MD   

The Developmental Research Program is designed to support new ideas and concepts that can be incorporated into translational research projects designed to solve clinical problems in lung cancer diagnosis and therapy. (link to all


​Award Period ​PI ​Project Title
​2008-2009 ​DeGregori, James PhD ​Genome-wide screen to identify therapuetic targets that synergize with gefitnib to treat NSCLC
​2008-2009 ​Mitas, Michael PhD ​Zeb1 as a therapeutic target and prognostic marker in non-small cell lung cancer
​2008-2009 ​Weiser-Evans, Mary PhD ​Role of Pioglitazone in Macrophage Function and Lung Cancer Progression and Metastasis
​2009-2010 ​Camidge, D. Ross MD PhD & Thorburn, Andrew M PhD ​Lung cancer cell death decision-making in response to platinum-based chemotherapy
​2009-2010 ​Doebele, Robert MD PhD ​ALK in NSCLC: Classification of gene rearrangement partners and development of a strategy to identify novel ALK gene abnormalities
​2009-2010 ​Nassare, Patrick PhD ​Targeting EMT-induced metastases in lung cancer through the Semaphorin/Neuropilin pathway
​2010-2011 ​DeGregori, James PhD ​Development of novel high-throughput approaches to validate and screen for genes and pathways whose inhibition potentiates gefitinib efficacy for NSCLC
​2010-2011 ​Gijon, Miguel A PhD ​Eicosanoid Profiling in Human Lung Cancer
​2010-2011 ​Reyland, Mary PhD ​Targeting Protein kinase C delta in K-Ras dependent NSCLC: evaluation of novel small molecule inhibitors
​2011-2012 ​Heasley, Lynn PhD ​Functional Genomics Screening for Novel Protein Kinas Drivers in Lung Cancer Cell Lines
​2011-2012 ​Kern, Jeff MD & Theodorescu, Dan MD PhD ​Ral GTPase as a Therapeutic Target in Pulmonary Adenocarcinomas
​2012-2013 ​Doebele, Robert MD PhD ​Targeting pathways to relieve proteotoxic stress to inhibit ALK+ NSCLC cell growth
​2012-2013 ​Weyant, Michael MD ​sPLA2 ILa in Lung Cancer - a Potential Therapeutic Target
​2013-2014 ​Bauer, Alison PhD ​Investigation of MUC5AC in mouse pulmonary neoplasia
​2013-2014 ​De, Subhajyoti PhD ​Detecting novel regulatory driver mutations in gene promoters in non-small cell lung cancer
​2014-2015 ​Kim, Jihye PhD ​A systems approach to elucidating molecular vulnerabilities and therapeutics in KRAS-mutant lung adenocarcinoma
​2014-2015 ​Thurman, Joshua MD ​The dual roles of complement activation in lung cancer