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University of Colorado Cancer Center

University of Colorado Cancer Center, A National Cancer Institute-designated Comprehensive Cancer Center
 

Cytogenetics Service


The CU Cancer Center Cytogenetics Service Laboratory provides access to technologies and expertise for, among other services, the identification of molecular markers predictive for benefit and resistance of solid tumors to targeted therapies, including fluorescence in situ hybridization (FISH).

Our services has played a pivotal role in developing reagents to determine copy number gain (CNG) and gene fusions using FISH assays in formalin-fixed, paraffin-embedded (FFPE) tissue. As a result of this work, FISH analysis of biomarkers in now applied in clinical settings.

We have experience with commercially available and laboratory developed probes, such as:

  • Chromosome enumeration probes
  • Painting probes
  • Probes for detection of chromosomal rearrangements
  • Single copy or locus-specific probes
  • Nick-translated DNA fragments
  • We also provide consulting services and training for non-assisted lab use.

    How to use this service lab:

    Testing and instrumentation are available by appointment only. Turnaround time is highly dependent on the specimen or project. Please contact Dr. Varella-Garcia to schedule your project and discuss turnaround times.