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Hormone Related Malignancies

The Hormone Related Malignancies Program (HRM) fosters cancer-focused inter-disciplinary research
among basic scientists, clinical researchers and epidemiologists who study cancers of the reproductive tract and breast. Our goal is to prevent, diagnose, and treat these cancers more effectively through the translation of lab-based discoveries into therapeutic targets.

Our researchers are engaged in translating their knowledge of those processes into biomarkers and therapeutic targets for cancer patients through clinical trials. Novel technologies and approaches developed by the program to address these areas include

  • Animal models to study epithelia to mesenchymal transition (EMT), cancer stem cells, apoptosis and the microenvironment's role in metastasis.
  • Functional genomic and high throughput screens to identify new drugs targeting novel pathways in HRM-related cancers.

Scientific Goals:

The HRM goal is to reduce the incidence and mortality from cancers of the reproductive tract and other hormone-related tumors by making basic discoveries that are translated into new diagnostic, preventive and treatment strategies.

Focus Groups:

  1. Women's Cancers - This group encompasses basic, clinical and epidemiology researchers focused on breast and gynecologic cancers. The group spans numerous different research topics including the role of hormones in breast and ovarian cancer, the development of hormone therapy resistance, the role of epithelial to mesenchymal transition and cancer stem cells in metastasis, among others.
  2. Prostate Cancer - This group encompasses basic and clinical researchers focused on prostate cancer with particular emphasis on prevention, screening, and novel therapies. The group has robust protocols for tissue and body fluid specimen collection encompassing a wide range of disease progression, providing valuable resources for molecular and biochemical analyses.

Program Activities:

Our program activities are focused on stimulating research collaborations between basic and clinical scientists, promoting cross-fertilization between our two focus groups, fostering our associate members to develop into independent researchers, and sponsoring the developments of multi-investigator research and training grants.  We achieve this through the following activities:

      • Weekly seminar series
      • Monthly disease focus group meetings
      • Biannual program retreats
      • Annual Cancer Center-wide retreats
      • Clinical conferences
      • Program-based mentoring program
      • Forums to foster early development efforts and provisions of financial support.