University of Colorado Anschutz Medical Campus, Center for Regenerative Medicine and Stem Cell Biology
The student must have completed two years of college
Number of Openings: 1
The primary goal of my lab is to define the role of the p53 tumor suppressor pathway in development and tumorigenesis. To accomplish this we are using murine models that carry different p53 mutations to assess the impact of these mutations on tumor initiation and progression. We are also checking the role of high levels of p53 on the development of the heart and the vascular system using mice.
A second major goal of the lab is to uncover the molecular mechanisms underlying pigmentary disorders like Vitiligo and Giant Congenital Nevi (GCN). Vitiligo and GCN are devastating disfiguring diseases that affect people of all races and socioeconomic levels.
Techniques routinely used in the lab include mouse husbandry and necropsies, routine molecular biology, quantitative PCR, microscopy, immunohistochemistry, immunocytochemistry, tissue culture, grafting and virus production.