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Clinical Division Faculty



Peter Gottlieb, MD
Professor of Pediatrics & Medicine
BioSketch

Understanding the molecular basis of autoantigen recognition utilizing human HLA and TCR transgenic mice and tetramer methodology.

The development of novel systems to monitor and characterize human T cell responses to islet autoantigens.

Design and implementation of immune intervention trials to alter or prevent the progression of type 1 diabetes in prediabetic and newly diagnosed individuals.

Design and implementation of the human islet transplantation unit at the Barbara Davis Center.

The genetic relationship between Addison's disease and type 1 diabetes.

Publications:

Ouyang Q, Standifer NE, Qin H, Gottlieb P, Verchere CB, Nepom GT, Tan R, Panagiotopoulos C.
Recognition of HLA class I-restricted beta-cell epitopes in type 1 diabetes.
Diabetes. 2006 Nov;55(11):3068-74.

Liu W, Putnam AL, Xu-Yu Z, Szot GL, Lee MR, Zhu S, Gottlieb PA, Kapranov P, Gingeras TR, Fazekas de St Groth B, Clayberger C, Soper DM, Ziegler SF, Bluestone JA.
CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cells.
J Exp Med. 2006 Jul 10;203(7):1701-11.

Gottlieb PA, Frias JP, Peters KA, Chillara B, Garg SK.
Optimizing insulin therapy in pregnant women with type 1 diabetes mellitus.
Treat Endocrinol. 2002;1(4):235-40. Review.

Gottlieb PA.
In vitro and in vivo approaches to prevention and cure of T1D.
Curr Diab Rep. 2005 Apr;5(2):77-8.

Barker JM, Yu J, Yu L, Wang J, Miao D, Bao F, Hoffenberg E, Nelson JC, Gottlieb PA, Rewers M, Eisenbarth GS.
Autoantibody "subspecificity" in type 1 diabetes: risk for organ-specific autoimmunity clusters in distinct groups.
Diabetes Care. 2005 Apr;28(4):850-5.

Heise CE, Pahuja A, Hudson SC, Mistry MS, Putnam AL, Gross MM, Gottlieb PA, Wade WS, Kiankarimi M, Schwarz D, Crowe P, Zlotnik A, Alleva DG.
Pharmacological characterization of CXC chemokine receptor 3 ligands and a small molecule antagonist.
J Pharmacol Exp Ther. 2005 Jun;313(3):1263-71

Izuora KE, Chase HP, Jackson WE, Coll JR, Osberg IM, Gottlieb PA, Rewers MJ, Garg SK.
Inflammatory markers and diabetic retinopathy in type 1 diabetes.
Diabetes Care. 2005 Mar;28(3):714-5.

Putnam AL, Vendrame F, Dotta F, Gottlieb PA.
CD4+CD25high regulatory T cells in human autoimmune diabetes.
J Autoimmun. 2005 Feb;24(1):55-62.

Steck AK, Barriga KJ, Emery LM, Fiallo-Scharer RV, Gottlieb PA, Rewers MJ.
Secondary attack rate of type 1 diabetes in Colorado families.
Diabetes Care. 2005 Feb;28(2):296-300.

Garg SK, Paul JM, Karsten JI, Menditto L, Gottlieb PA.
Reduced severe hypoglycemia with insulin glargine in intensively treated adults with type 1 diabetes.
Diabetes Technol Ther. 2004 Oct;6(5):589-95.

Barker JM, Ide A, Hostetler C, Yu L, Miao D, Fain PR, Eisenbarth GS, Gottlieb PA.
Endocrine and immunogenetic testing in individuals with type 1 diabetes and 21-hydroxylase autoantibodies: Addison's disease in a high-risk population.
J Clin Endocrinol Metab. 2005 Jan;90(1):128-34.

Garg SK, Gottlieb PA, Hisatomi ME, D'Souza A, Walker AJ, Izuora KE, Chase HP.
Improved glycemic control without an increase in severe hypoglycemic episodes in intensively treated patients with type 1 diabetes receiving morning, evening, or split dose insulin glargine.
Diabetes Res Clin Pract. 2004 Oct;66(1):49-56.

Ott PA, Dittrich MT, Herzog BA, Guerkov R, Gottlieb PA, Putnam AL, Durinovic-Bello I, Boehm BO, Tary-Lehmann M, Lehmann PV.
T cells recognize multiple GAD65 and proinsulin epitopes in human type 1 diabetes, suggesting determinant spreading.
J Clin Immunol. 2004 Jul;24(4):327-39.

Eisenbarth GS, Gottlieb PA.
Autoimmune polyendocrine syndromes.
N Engl J Med. 2004 May 13;350(20):2068-79. Review.

Gottlieb PA.
Type 1 diabetes.
Endocrinol Metab Clin North Am. 2004 Mar;33(1):xiii-xiv.

Vendrame F, Gottlieb PA.
Prediabetes: prediction and prevention trials.
Endocrinol Metab Clin North Am. 2004 Mar;33(1):75-92, ix. Review.

Kelemen K, Gottlieb PA, Putnam AL, Davidson HW, Wegmann DR, Hutton JC.
HLA-DQ8-associated T cell responses to the diabetes autoantigen phogrin (IA-2 beta) in human prediabetes.
J Immunol. 2004 Mar 15;172(6):3955-62.

Garg SK, Walker AJ, Hoff HK, D'Souza AO, Gottlieb PA, Chase HP.
Glycemic parameters with multiple daily injections using insulin glargine versus insulin pump.
Diabetes Technol Ther. 2004 Feb;6(1):9-15.

Schloot NC, Meierhoff G, Karlsson Faresjo M, Ott P, Putnam A, Lehmann P, Gottlieb P, Roep BO, Peakman M, Tree T.
Comparison of cytokine ELISpot assay formats for the detection of islet antigen autoreactive T cells. Report of the third immunology of diabetes society T-cell workshop.
J Autoimmun. 2003 Dec;21(4):365-76.

Garg SK, Frias JP, Anil S, Gottlieb PA, MacKenzie T, Jackson WE.
Insulin lispro therapy in pregnancies complicated by type 1 diabetes: glycemic control and maternal and fetal outcomes.
Endocr Pract. 2003 May-Jun;9(3):187-93.

Eisenbarth GS, Moriyama H, Robles DT, Liu E, Yu L, Babu S, Redondo MJ, Gottlieb P, Wegmann D, Rewers M.
Insulin autoimmunity: prediction/precipitation/prevention type 1A diabetes.
Autoimmun Rev. 2002 May;1(3):139-45. Review. Erratum in: Autoimmun Rev. 2006 May;5(5):364. Redondo, Maria [corrected to Redondo, Maria J].

Lee PT, Putnam A, Benlagha K, Teyton L, Gottlieb PA, Bendelac A.
Testing the NKT cell hypothesis of human IDDM pathogenesis.
J Clin Invest. 2002 Sep;110(6):793-800.

Gottlieb PA, Hayward AR.
Cytokine and immunosuppressive therapies of type 1 diabetes mellitus.
Endocrinol Metab Clin North Am. 2002 Jun;31(2):477-95. Review.

Robles DT, Fain PR, Gottlieb PA, Eisenbarth GS.
The genetics of autoimmune polyendocrine syndrome type II.
Endocrinol Metab Clin North Am. 2002 Jun;31(2):353-68, vi-vii. Review.

Alleva DG, Gaur A, Jin L, Wegmann D, Gottlieb PA, Pahuja A, Johnson EB, Motheral T, Putnam A, Crowe PD, Ling N, Boehme SA, Conlon PJ.
Immunological characterization and therapeutic activity of an altered-peptide ligand, NBI-6024, based on the immunodominant type 1 diabetes autoantigen insulin B-chain (9-23) peptide.
Diabetes. 2002 Jul;51(7):2126-34.

Gottlieb PA, Eisenbarth GS.
Insulin-specific tolerance in diabetes.
Clin Immunol. 2002 Jan;102(1):2-11. Review.

To access a more complete listing of publications, please go to PubMed http://www.ncbi.nlm.nih.gov/PubMed/ and use the search term Barbara Davis Center for Childhood Diabetes or enter individual author names.
Please direct inquiries to specific e-mail addresses listed within individual entries. For all other general Research inquiries, please contact:
kathryn.gray@ucdenver.edu