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Pilot & Feasibility Program

Center for American Indian and Alaska Native Diabetes Translation Research

The Pilot and Feasibility Program supports small scale research projects that explore the extension of diabetes prevention and treatment research – with spec​ial emphasis on reducing risk as well as enhancing clinical outcomes – to American Indians and Alaska Natives (AI/ANs). CAIANDTR is particularly interested in stimulating work that considers the relevance of recent discoveries for application within Native communities. Toward this end, we will soon be soliciting a new round of proposals from University of Colorado Denver faculty.

This funding opportunity provides two (2) years of support, at $25,000 per year, to either new investigators in the process of establishing careers in diabetes prevention and/or treatment research or mid-career scientists seeking to redirect their efforts to translation research consistent with our mission. Successful applicants will be expected to pursue the research in question among an AI/AN community for whom such work is of high priority. CAIANDTR will assist investigators in establishing the academic/community partnerships necessary to undertake funded projects. The proposed study must be scientifically meritorious, be feasible within the time and resources available, hold promise of local benefit, and suggest a line of inquiry that can continue beyond the terms of this initial investment.

​​Currently Funded Projects

Food insecurity and healthful eating for American Indian and Alaska Native adults with type 2 diabetes: Perspectives from key stakeholders

Sarah Stotz, PhD, MS, RD, CDE, LD

Food insecurity is well documented as a barrier to healthful eating and diabetes self-management. American Indians and Alaska Natives (AI/AN) are twice as likely to experience food insecurity and type 2 diabetes (T2D) than non-AI/ANs. For this proposed project, we will conduct secondary analyses on the qualitative data collected as part of a needs assessment aimed to inform the cultural adaptation of an existing diabetes nutrition education program for AI/AN adults with T2D. This project will explore themes regarding food insecurity and healthful eating for diabetes management in AI/AN communities, as described by AI/ANs with T2D and key stakeholders. Findings from the project will serve as preliminary study to support a future large-scale grant proposal to develop AI/AN-specific nutrition education interventions that address food insecurity as it pertains to diabetes self-management.

Spatial clustering and associated determinants of diabetes in Navajo youth

Christine Wey Hockett, PhD, Dana Dabelea, MD, PhD, Sonya S. Shin, MD, MPH, Michael C. Wimberly, PhD, Phoutdavone Phimphasone-Brady, PhD, and Anna Bellatorre, PhD

American Indian youth (aged 0-19 years) have the highest incidence of pediatric type 2 diabetes (T2D) in the United States; however, there is limited research on the geographic variation of T2D in youth, and none in high-risk populations, such as American Indians. In response to this gap in the literature, this project will build upon our long-standing collaborations between academic researchers and Native stakeholders to identify areas within Navajo Nation that have a higher than expected burden of T2D (hotspots) and explore what ecological characteristics explain these hotspots. The specific aims of our project are 1) to identify spatial clusters of T2D incident cases in Native youth on Navajo Nation from 2002 through 2016, 2) determine what social and environmental determinants are associated with high-risk clusters of T2D on Navajo Nation; and 3) host a half-day mini-summit, involving key community stakeholders, to disseminate the results of the project. Key community stakeholders may be able to use these results to prioritize resources and target efforts for pediatric diabetes prevention.​


 ​​Previously Funded Pilot Projects

Clinical and Social Determinants of Health for Obesity: A Lifespan investigation of overweight/obesity among American Indians and Alaska Natives

Cheryl Conway, PhD,  Amber Fyfe-Johnson, PhD, Vanessa Hiratsuka, PhD, Kimberly Huyser, PhD, and Michelle Johnson-Jennings, PhD

American Indians and Alaska Natives (AI/ANs) have a prevalence of diabetes that is 2 to 3 times that of the general U.S. population. Obesity, a key risk factor for type 2 diabetes, is common in AI/AN populations and often begins in early childhood.  The prevalence of obesity is significantly higher among Native preschoolers, school-aged children, youth, and adults than in the comparable subgroups of the general U.S. population. Social determinants of health (SDOH), or the conditions in which people are born, grow, live, and work (e.g., socioeconomic conditions, access to health care, and food access and security), are known to influence racial disparities in health outcomes. Although some research suggests that SDOH may play an important role in the high rates of obesity, diabetes, and cardiovascular disease among Native people, the literature does not provide clear conclusions regarding the association of SDOH with diabetes-related outcomes in Native populations.

The objective of this pilot project is to investigate the relationship between SDOH and diabetes outcomes in AI/ANs, using a life course perspective. Analyzing longitudinal data available from the Indian Health Service’s (IHS) Improving Health Care Delivery Data Project (IHCDDP), five Early-Stage Investigators from our collaborating Satellite Centers are addressing three specific aims: 1) the association of SDOH with diabetes-related outcomes among AI/AN mothers (obesity, gestational diabetes) and birthweight of Native newborns; 2) the association of SDOH with diabetes-related outcomes among Native children,  adolescents, and young adults (Body Mass Index, pre-diabetes, diabetes); and 3) the association of food access and security with diabetes-related outcomes among Native elders.

Engaging Families to Improve Diabetes Management at an Urban Indian Health Organization

Meredith Fort, PhD
Type 2 diabetes is one of the most common chronic conditions in the US, and disproportionately affects American Indians who have the highest prevalence among all racial and ethnic groups. One promising approach to support patients in managing their diabetes is the engagement of family members. Families are important in chronic disease management and care among American Indians/Alaska Natives, but much less is known about urban American Indians, whose families may be dispersed between urban and reservation communities. We propose a study building on the infrastructure of a recently-funded, collaborative study including the Centers for American Indian and Alaska Native Health and the Institute for Health Research aimed at improving hypertension management among clients who receive care at the First Nations Community Healthsource (FNCH) in Albuquerque, New Mexico. In specific aim 1, we will use a combination of qualitative methods including individual and family interviews, genograms and eco-maps, to identify the roles, relationships and resources of patients and their family members that influence improved or
inhibited medication adherence, appointment-keeping, and implementation of self-management plans. In specific aim 2, we will engage patients, family members and an advisory board in the development of family-focused strategies for improved disease management. The results of this study will inform the parent study and will lay the foundation for a future study that will assess ways to engage families in supporting patients with diabetes and hypertension in ongoing self-care.

Pediatric Obesity and Type 2 Diabetes in American Indian Youth

Katherine Sauder, PhD
Pediatric obesity and type 2 diabetes (T2D) are global public health problems worldwide, and American Indian (AI) youth have the highest incidence and prevalence of T2D in the United States. We recently completed an 8-month pilot and feasibility trial of a behavioral intervention designed to reduce these risks in 62 overweight/obese AI youth aged 7-10 years. To maintain the momentum of this research and to guide dissemination and implementation plans across AI communities, we conducted a 1-year community-based participatory research process with Navajo Nation in conjunction with the Special Diabetes Program for Indians (SDPI). Our specific aims are: 1) to share the findings of the pilot study with study participants, TTPP research team, local community leaders, and relevant stakeholders; 2) to explore opportunities for the sustainable implementation of the program within the larger Navajo Nation community; 3) to plan for a larger dissemination and implementation research study that will expand the program to additional AI communities. By continuing our collaboration with Navajo Nation and using lessons learned from SDPI, we can prepare to expand the TTPP for youth in AI communities in a sustainable, effective manner.

​American Indian and TOPS Collaboration for Health (AITCH)

Nia Mitchell, MD
American Indians are at increased risk for Type 2 diabetes compared to other Americans. A primary risk factor for diabetes is being overweight or obese, and American Indians are more likely to be overweight or obese than other Americans.  Therefore, effective interventions focused on weight management hold promise for diminishing the diabetes-related disparities American Indians face.  Take Off Pounds Sensibly (TOPS) is a nonprofit, low-cost, peer-led, nationally available weight loss program, and a recent study showed that TOPS helped people lose 5% of their initial weight and maintain the weight loss for up to 3 years.  Each TOPS chapter decides the types of programs it would like to include; therefore each chapter can be tailored to fit the needs of its members. The objective of this project is to explore and address barriers to the diffusion of TOPS in the American Indian community in the Denver metropolitan area by offering the program to 50 American Indian participants through a local community organization that serves the American Indian community.  Both qualitative and quantitative assessments will be utilized. Surveys will be used to evaluate the eating and physical activity patterns, self efficacy, and stages of change pre- and post-intervention.  Focus groups will be used to determine the feasibility and acceptability of the program and to get feedback on ways to tailor the program to the American Indian community.  We will also assess the weight change of participants over a 12 week intervention.

Numeracy Intervention to Improve Diabetes Self-care (NIIDS) 

Angela Brega, PhD
Growing evidence suggests that the ability to understand and use numbers (“numeracy”) may have important implications for diabetes self-care.  Compared to patients with stronger numerical skills, those with limited numeracy check their blood sugar levels less frequently, are less likely to adjust their insulin doses based on carbohydrate intake and blood sugar levels, have less confidence that they can manage their diabetes (i.e., self-efficacy), and have worse glycemic control. The objective of this project is to develop a computerized intervention to teach American Indian patients a subset of the numeracy skills needed to manage diabetes.  The intervention will focus on three sets of self-care skills (understanding blood glucose values, monitoring carbohydrate intake, managing cardiovascular risk) and will be culturally tailored for the American Indian tribe that is participating in the project.  The computerized intervention will incorporate audio- and video-based education and will comply with recommendations for clear communication of health information.  Pilot testing of the intervention will be conducted with 50 American Indian patients with diabetes from a large Indian Health Service clinic serving our partner tribe.  Using a pre-post design, we will examine change over time in diabetes numeracy, self-efficacy, stage of change, and self-care behavior.

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