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Ann Kimble-Hill

I have a broad background in biophysics, with specific training and expertise in fluorescence microscopy, fluorescence spectroscopy, x-ray crystallography, small angle scattering. I use biological membranous mimics to characterize dynamic protein-lipid interactions. As a recipient of the NCI K01 award, I have concentrated on the role of Amot family members in the progression from ductal hyperplasia to breast cancer. This work focuses on two distinct areas: 1) characterization of the lipid platform necessary for Amot coiled-coil homology (ACCH) domain affinity for membranes, and 2) determination of the ACCH domain residues responsible for initiation of the lipid binding event. We combine traditional cell biology/biochemistry techniques with those basic science aspects of biophysics to give a broader understanding of cellular signal transduction in this cancer model.

Colorado School of Public Health

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Aurora, CO 80045


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