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Keating Lab



Phone:     (303) 724-4027


Research Interests:


Targeting Mer and Axl receptor tyrosine kinase in astrocytic brain tumors.


Selected Publications:

1. Lymphoblastic leukemia / lymphoma in mice overexpressing the Mer (MerTK) receptor tyrosine kinase. Keating AK, Salzberg DB, Sather S, Liang X, Nickoloff S, Anwar A, Deryckere D, Hill K, Joung D, Sawczyn KK, Park J, Curran-Everett D, McGavran L, Meltesen L, Gore L, Johnson GL, Graham DK. Oncogene. 2006 Oct 5;25(45):6092-100. Epub 2006 May 1


2. Ectopic expression of the proto-oncogene Mer in pediatric T-cell acute lymphoblastic leukemia. Graham DK, Salzberg DB, Kurtzberg J, Sather S, Matsushima GK, Keating AK, Liang X, Lovell MA, Williams SA, Dawson TL, Schell MJ, Anwar AA, Snodgrass HR, Earp HS. Clin Cancer Res. 2006 May 1;12(9):2662-9.


3. TAM receptor tyrosine kinases: biologic functions, signaling, and potential therapeutic targeting in human cancer. Linger RM, Keating AK, Earp HS, Graham DK. Adv Cancer Res. 2008;100:35-83.


4. Mer tyrosine kinase (MerTK) promotes macrophage survival following exposure to oxidative stress. Anwar A, Keating AK, Joung D, Sather S, Kim GK, Sawczyn KK, Brandão L, Henson PM, Graham DK. J Leukoc Biol. 2009 Jul;86(1):73-9. Epub 2009 Apr 22.


5. Inhibition of Mer and Axl Receptor Tyrosine Kinases Reduces Astrocytoma Cell Growth and Increases Chemosensitivity. Keating AK, Kim GK, Donson A, Ware K, Salzberg DB, Foreman N, Liang X, Graham DK. Molecular Cancer Therapeutics, Manuscript under Revision.

6. Mer receptor tyrosine kinase is a novel therapeutic target in pediatric B-cell acute lymphoblastic leukemia. Linger RM, DeRyckere D, Brandão L, Sawczyn KK, Jacobsen KM, Liang X, Keating AK, Graham DK Blood. 2009 Sep 24;114(13):2678-87. Epub 2009 Jul 30.

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