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University of Colorado Denver

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Protein Folding and Function: Dr. Mallela Research Laboratory

Lab Members


Dinen Shah: Graduate Student
Phone: 303-724-3577
Email: Dinen.Shah@ucdenver.edu

Dinen’s current research is on determining the effects of lipid peroxidation products on the structure and function of a heat shock protein, 78 kDa glucose-regulated protein (GRP78).

Dr. Surinder M. Singh: Postdoctoral Fellow
Phone: 303-724-3577
Email: Surinder.Singh@ucdenver.edu

Surinder’s current research is on characterizing the biophysics of dystrophin and utrophin, two key proteins involved in muscular dystrophy.

Dr. Swati Bandi: Postdoctoral Fellow
Phone: 303-724-3577
Email: Swati.Bandi@ucdenver.edu

Swati’s current research is on characterizing the structural dynamics of tandem calponin-homology domains of dystrophin and utrophin.

Dr. Regina L. Bis: Postdoctoral Fellow
Phone: 303-724-3577
Email: Regina.Bis@ucdenver.edu

Regina’s current research is on determining the mechanisms of alcohol and antimicrobial-preservative-induced aggregation of a model protein cytochrome c and a pharmaceutical protein interferon alpha-2a.

Lab Alumni

Justine F. Molas: Graduate Student

Justine optimized the expression and purification protocols of dystrophin and utrophin, and did initial biophysical characterization of these proteins.

Darin Brown: Graduate Student

Darin worked on the expression and purification of death domains, Fas, FADD, DR4 & DR5, which are involved in apoptotic signaling pathways.

Joseph Rower: Graduate Student

Joseph worked on the effect of Hofmeister series on thermal aggregation of cytochrome c.

Dr. Javier Cabello-Villegas: Postdoctoral Fellow

Javier performed NMR relaxation experiments on dystrophin, and hydrogen exchange experiments on the effects of antimicrobial preservatives on cytochrome c.

Dr. Narsimulu Kongari: Postdoctoral Fellow

Narsimulu worked on optimizing the expression and purification of dystrophin and utrophin, and performed initial biophysical characterization using analytical ultracentrifugation (AUC) and NMR relaxation.

Collaborators

Geoffrey Armstrong, University of Colorado Boulder
NMR experiments on utrophin and dystrophin

David Fela, NPS Pharmaceuticals
Biophysical characterization of parathyroid hormone (PTH) using NMR

Thomas Lavoie, PBL Assay Science
Functional assays on interferon alpha-2a

David Nesbitt, University of Colorado Boulder
Fluorescence experiments on dystrophin and utrophin

Tara Stauffer, PBL Assay Science
Antiviral and antiproliferative assays on interferon alpha-2a

Steve Winder, University of Sheffield
Expression vectors of dystrophin and utrophin N-ABDs, and their purification and actin-binding assays

Deborah Wuttke, University of Colorado Boulder
NMR experiments on dystrophin and utrophin