The Pediatric Heart Lung Center is an interdisciplinary research group that primarily studies mechanisms underlying normal lung vascular development and how disruption of this process contributes to neonatal lung and cardiovascular disorders, especially pulmonary hypertension and lung hypoplasia. Animal models include approaches to better understand antenatal causes of lung disease, such as preeclampsia and chorioamnionitis, in rats and mice. Physiologic, histologic and morphometric approaches are used to quantify changes in lung structure and function. Additional studies involve endothelial cell studies in vitro, as well as molecular and biochemical strategies for investigating basic mechanisms of disease. Ongoing projects are exploring the roles of enhancing endothelial function to prevent pulmonary vascular disease in the fetus and newborn, including novel pharmacologic agents and other strategies.